Botulinum toxin intoxication requires retrograde transport and membrane translocation at the ER in RenVM neurons.

Autor: Yeo JC; Institute of Molecular and Cell Biology, Singapore, Singapore., Tay FP; Institute of Molecular and Cell Biology, Singapore, Singapore., Bennion R; Centre de Recherche en Cancérologie de Marseille, Aix Marseille Université, Inserm, CNRS, Institut Paoli-Calmettes, Equipe Leader Fondation ARC 2021, Marseille, France., Loss O; Ipsen Bioinnovation, London, United Kingdom., Maignel J; Ipsen Innovation, Les Ulis, France., Pons L; Ipsen Innovation, Les Ulis, France., Foster K; Ipsen Bioinnovation, London, United Kingdom., Beard M; Ipsen Bioinnovation, London, United Kingdom., Bard F; Institute of Molecular and Cell Biology, Singapore, Singapore.; Centre de Recherche en Cancérologie de Marseille, Aix Marseille Université, Inserm, CNRS, Institut Paoli-Calmettes, Equipe Leader Fondation ARC 2021, Marseille, France.

Publikováno v: ELife [Elife] 2024 Aug 28; Vol. 12. Date of Electronic Publication: 2024 Aug 28.

AbobotulinumtoxinA improves skin properties and sebum quality in the rhino mouse.

Autor: Maignel J; Ipsen Innovation, Les Ulis, France. Electronic address: jacquie.maignel@ipsen.com., Albinet V; Imavita, Toulouse, France., Chusseau M; Imavita, Toulouse, France., Lacoste E; Imavita, Toulouse, France.

Publikováno v: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2023 Sep; Vol. 233, pp. 107230. Date of Electronic Publication: 2023 Jul 28.

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2 ⁺ DRG sensory neurons.

Autor: Yang NJ; Department of Immunology, Harvard Medical School, Boston, MA, USA., Isensee J; Translational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Neel DV; Department of Immunology, Harvard Medical School, Boston, MA, USA., Quadros AU; Center for Research in Inflammatory Diseases, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Zhang HB; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Lauzadis J; Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, USA., Liu SM; Ipsen Bioinnovation Ltd, Abingdon, UK., Shiers S; Department of Neuroscience, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA., Belu A; Translational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Palan S; Ipsen Bioinnovation Ltd, Abingdon, UK., Marlin S; Ipsen Bioinnovation Ltd, Abingdon, UK., Maignel J; Ipsen Innovation, Les Ulis, France., Kennedy-Curran A; Department of Immunology, Harvard Medical School, Boston, MA, USA., Tong VS; Department of Immunology, Harvard Medical School, Boston, MA, USA., Moayeri M; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Röderer P; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Bonn, Germany.; Cellomics Unit, LIFE & BRAIN GmbH, Bonn, Germany., Nitzsche A; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Bonn, Germany.; Cellomics Unit, LIFE & BRAIN GmbH, Bonn, Germany., Lu M; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Brüstle O; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty and University Hospital Bonn, Bonn, Germany., Tripathi V; Ipsen Bioinnovation Ltd, Abingdon, UK., Foster KA; Ipsen Bioinnovation Ltd, Abingdon, UK., Price TJ; Department of Neuroscience, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA., Collier RJ; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Leppla SH; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Puopolo M; Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, USA., Bean BP; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Cunha TM; Center for Research in Inflammatory Diseases, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Hucho T; Translational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Chiu IM; Department of Immunology, Harvard Medical School, Boston, MA, USA. Isaac_Chiu@hms.harvard.edu.

Publikováno v: Nature neuroscience [Nat Neurosci] 2022 Feb; Vol. 25 (2), pp. 168-179. Date of Electronic Publication: 2021 Dec 20.

BoNT/A in the Urinary Bladder-More to the Story than Silencing of Cholinergic Nerves.

Autor: Ibrahim H; Department of Pharmacy and Biomedical Science, University of Central Lancashire, Preston PR1 2HE, UK., Maignel J; Ipsen Innovation, 5 Avenue du Canada, 91940 Les Ulis, France., Hornby F; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK., Daly D; Department of Pharmacy and Biomedical Science, University of Central Lancashire, Preston PR1 2HE, UK., Beard M; Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.

Publikováno v: Toxins [Toxins (Basel)] 2022 Jan 12; Vol. 14 (1). Date of Electronic Publication: 2022 Jan 12.

New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A.

Autor: Silkina, Marina Vladimirovna¹, Kartseva, Alena Sergeevna¹, Riabko, Alena Konstantinovna¹, Makarova, Mariia Aleksandrovna¹, Rogozin, Metkhun Madibronovich¹, Romanenko, Yana Olegovna¹, Shemyakin, Igor Georgievich¹, Dyatlov, Ivan Alekseevich¹, Firstova, Victoria Valerievna¹ firstova@obolensk.org

Publikováno v: BioImpacts. Jul2024, Vol. 14 Issue 4, p1-14. 14p.