Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maigan A. Hulme"'
Autor:
Todd M Brusko, Clive H Wasserfall, Maigan A Hulme, Roniel Cabrera, Desmond Schatz, Mark A Atkinson
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7980 (2009)
CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells. Recent genome wide association studies have implicated the CD25
Externí odkaz:
https://doaj.org/article/ff7867a38ed84fc1b41bac95873e1ec4
Autor:
Maigan A. Hulme, Clive Wasserfall, Desmond A. Schatz, Michael J. Haller, Clayton E. Mathews, Todd M. Brusko, Jonathan J. Shuster, Kieran M. Mcgrail, Amanda L. Posgai, Mark A. Atkinson, Miriam Cintron
Publikováno v:
Clinical and Experimental Immunology. 183:350-357
Summary Granulocyte colony-stimulating factor (G-CSF) has been used to restore immune competence following chemoablative cancer therapy and to promote immunological tolerance in certain settings of autoimmunity. Therefore, we tested the potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c492156b119df7090232698097d7c35
https://doi.org/10.1111/cei.12731
https://doi.org/10.1111/cei.12731
Autor:
Daniel J. Perry, Maigan A. Hulme, Andrew R Schultz, Baiming Zou, Todd M. Brusko, Aaron W. Michels, Desmond A. Schatz, Amanda L. Posgai, Mark A. Atkinson, Stephen E. Gitelman, Peter A. Gottlieb, Clive Wasserfall, Jonathan J. Shuster, Clayton E. Mathews, Michael J. Haller
Publikováno v:
Diabetes, vol 65, iss 12
Diabetes
Diabetes
Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes. Herein, we describe metabolic and immunological parameters 24 months following tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c76e0e40d846b3559bf69e20430641e
https://escholarship.org/uc/item/80s9w221
https://escholarship.org/uc/item/80s9w221
Autor:
Maigan A. Hulme, Stephanie McClymont, Jeffrey A. Bluestone, Weihong Liu, Amy L. Putnam, Jonathan H. Esensten, Udo Baron, Sven Olek, Ulrich Hoffmüller, Todd M. Brusko, Michael R. Lee
Publikováno v:
The Journal of Immunology. 186:3918-3926
Regulatory T cells (Tregs) constitute an attractive therapeutic target given their essential role in controlling autoimmunity. However, recent animal studies provide evidence for functional heterogeneity and lineage plasticity within the Treg compart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa15ed234403bbf4c0105516bd46f47f
https://doi.org/10.4049/jimmunol.1003099
https://doi.org/10.4049/jimmunol.1003099
Publikováno v:
Immunological Investigations. 36:607-628
Regulatory T cells (Treg) play a vital role in controlling peripheral immune responses in order to prevent autoimmunity and control inflammation. Altered Treg activities have been associated with the pathogenesis of multiple disorders including autoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6a46c6db9b8714466e3a5469455b27
https://doi.org/10.1080/08820130701790368
https://doi.org/10.1080/08820130701790368
Autor:
Maigan A. Hulme, Clive Wasserfall, Theresa M. Sumrall, Jonathan J. Shuster, Desmond A. Schatz, John R. Wingard, Douglas W. Theriaque, Mark A. Atkinson, Todd M. Brusko, Miriam Cintron, Michael J. Haller, Kieran M. Mcgrail
Publikováno v:
Diabetes Care
OBJECTIVE We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d48db30fde331fdb0704fcc69bc972
https://doi.org/10.2337/dc11-1406
https://doi.org/10.2337/dc11-1406
Autor:
Maigan A. Hulme, Aaron W. Michels, Clayton E. Mathews, Jonathan J. Shuster, Michael J. Haller, Peter A. Gottlieb, Stephen E. Gitelman, Baiming Zou, Todd M. Brusko, Clive Wasserfall, Stephen M. Rosenthal, Desmond A. Schatz, Mark A. Atkinson
Publikováno v:
The Journal of clinical investigation, vol 125, iss 1
BackgroundPrevious efforts to preserve β cell function in individuals with type 1 diabetes (T1D) have focused largely on the use of single immunomodulatory agents administered within 100 days of diagnosis. Based on human and preclinical studies, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0f3898a16f114d094f8034152d3a99
https://pubmed.ncbi.nlm.nih.gov/25500880
https://pubmed.ncbi.nlm.nih.gov/25500880
Autor:
Mark A. Atkinson, Clive Wasserfall, Peter J. Hong, Todd M. Brusko, Priya Saikumar Lakshmi, Desmond A. Schatz, Maigan A. Hulme, Michael J. Haller, Courtney B. Myhr
Type 1 Diabetes (T1D) is an autoimmune disorder characterized by aberrant T cell responses. Innate immune activation defects may facilitate a T helper 1 (Th1) phenotype. The cytokine IL-18 synergizes with IL-12 to induce IFNγ production and Th1 diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e2282ceec5b9b64a2b4d37a8e92d76
https://europepmc.org/articles/PMC3775347/
https://europepmc.org/articles/PMC3775347/
Autor:
Roberto Calcedo, James M. Wilson, Maigan A. Hulme, Lee P. Richman, Brenna Carey, Noel G. McElvaney, Guo-jie Ye, Ann Dongtao Fu, Mark L. Brantly, Todd M. Brusko, Margaret Humphries, Jeffrey D. Chulay, Qiushi Tang, Anthony T. Yachnis, Terence R. Flotte, Christian Mueller, Martha Campbell-Thompson, Farshid N. Rouhani, Bruce C. Trapnell, Suryanarayan Somanathan, Louis M. Messina, David R. Knop, Robert A. Sandhaus, Robert H. Vonderheide
Publikováno v:
The Journal of clinical investigation. 123(12)
Recombinant adeno-associated virus (rAAV) vectors have shown promise for the treatment of several diseases; however, immune-mediated elimination of transduced cells has been suggested to limit and account for a loss of efficacy. To determine whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60f0a498f6dac2c74a04c487648d761
https://pubmed.ncbi.nlm.nih.gov/24231351
https://pubmed.ncbi.nlm.nih.gov/24231351
Autor:
Marianne Kozuch, Michael J. Clare-Salzler, Clive Wasserfall, Miriam Cintron, Desmond A. Schatz, Mark A. Atkinson, John R. Wingard, Michael J. Haller, Todd M. Brusko, Jonathan J. Shuster, Maigan A. Hulme, Douglas W. Theriaque, Keiran M. McGrail, Ronald J. Ferguson
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(7)
We sought to determine if autologous umbilical cord blood (UCB) infusion followed by 1 year of supplementation with vitamin D and docosahexaenoic acid (DHA) can preserve C-peptide in children with type 1 diabetes. We conducted an open-label, 2:1 rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad31c2145b1a94bb2cc15969fc6a19a
https://pubmed.ncbi.nlm.nih.gov/23611977
https://pubmed.ncbi.nlm.nih.gov/23611977