BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability.

Autor: Silva MP; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Ferreira LT; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Brás NF; LAQV, REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal., Torres L; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Brandão A; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Pinheiro M; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Cardoso M; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Resende A; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Vieira J; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Palmeira C; Department of Immunology, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Martins G; Department of Immunology, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Silva M; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Pinto C; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Peixoto A; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Silva J; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Henrique R; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Maia S; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal., Maiato H; Chromosome Instability & Dynamics Group, Instituto de Investigação e Inovação em Saúde, University of Porto / Porto Comprehensive Cancer Center, Porto, i3S, Portugal.; Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal., Teixeira MR; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.; School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal., Paulo P; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal. paula.paulo@ipoporto.min-saude.pt.

Publikováno v: Journal of biomedical science [J Biomed Sci] 2024 Jul 16; Vol. 31 (1), pp. 74. Date of Electronic Publication: 2024 Jul 16.

Double-checking chromosome segregation.

Autor: Maiato H; Chromosome Instability & Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto, Portugal.; Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto, Portugal.; Department of Biomedicine, Cell Division Group, Faculdade de Medicina, Universidade do Porto, Porto, Portugal., Silva S; Chromosome Instability & Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto, Portugal.; Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto, Portugal.

Publikováno v: The Journal of cell biology [J Cell Biol] 2023 May 01; Vol. 222 (5). Date of Electronic Publication: 2023 Apr 05.

Purification of mammalian tubulins and tubulin-associated proteins using a P2A-based expression system

Autor: Yu, Nuo, Galjart, Niels, Maiato, H.

Publikováno v: Cytoskeleton Dynamics : methods and protocols, 2101, 1-17
Methods in Molecular Biology ISBN: 9781071602188

The microtubule cytoskeleton plays a crucial role in a myriad of cellular events, including mitosis, cell differentiation, migration, and the maintenance of cell shape. Microtubules are assembled from α- and β-tubulin heterodimers, whose biosynthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8277ba1a36b40c135a005b77be655684
https://pure.eur.nl/en/publications/091fd246-9a1f-489f-8d38-04764c32c74c

CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner.

Autor: Luo W; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Demidov V; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Shen Q; Department of Cell Biology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.; Nanobiology Institute, Yale University, West Haven, CT 06516, USA., Girão H; Chromosome Instability & Dynamics Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal., Chakraborty M; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Maiorov A; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ataullakhanov FI; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 119991 Moscow, Russian Federation.; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141701, Russian Federation., Lin C; Department of Cell Biology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.; Nanobiology Institute, Yale University, West Haven, CT 06516, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA., Maiato H; Chromosome Instability & Dynamics Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; Cell Division Group, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal., Grishchuk EL; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Science advances [Sci Adv] 2023 Jan 04; Vol. 9 (1), pp. eabq5404. Date of Electronic Publication: 2023 Jan 04.

Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis.

Autor: Feijão T; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139 Faro, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, 4200-135 Portugal.; Department of Medical Sciences and Institute for Biomedicine, Universidade de Aveiro, 3810-193 Aveiro, Portugal., Marques B; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139 Faro, Portugal., Silva RD; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139 Faro, Portugal.; Faculty of Medicine and Biomedical Sciences, Universidade do Algarve, 8005-139 Faro, Portugal., Carvalho C; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Sobral D; Associate Laboratory i4HB - Institute for Health and Bioeconomy, School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.; Applied Molecular Biosciences Unit (UCIBIO), Department of Life Sciences, School of Science and Technology, NOVA University Lisbon, Caparica, 2819-516 Portugal., Matos R; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139 Faro, Portugal., Tan T; Department of Biology, Brandeis University, Waltham, MA 02453., Pereira A; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, 4200-135 Portugal., Morais-de-Sá E; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, 4200-135 Portugal., Maiato H; Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, 4200-135 Portugal., DeLuca SZ; Department of Biology, Brandeis University, Waltham, MA 02453., Martinho RG; Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139 Faro, Portugal.; Department of Medical Sciences and Institute for Biomedicine, Universidade de Aveiro, 3810-193 Aveiro, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Oct 18; Vol. 119 (42), pp. e2204701119. Date of Electronic Publication: 2022 Oct 10.