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pro vyhledávání: '"Maia L. Simmons"'
Autor:
Maia L Simmons, Daniel J. Smith
Publikováno v:
Journal of Controlled Release. 51:153-159
Adverse physiological effects can often interfere with the use of nitric oxide (NO) as a therapeutic agent, especially when it is systemically generated from prodrugs. NO which is generated and delivered site-specifically by transdermal donors may be
Autor:
Joseph A. Hrabie, Daniel L. Mooradian, Thomas C. Hutsell, Stephen R. Hanson, Pulfer Sharon, Debashish Chakravarthy, Daniel J. Smith, Michael L. Citro, Keith M. Davies, Maia L. Simmons, Larry K. Keefer, Joseph E. Saavedra
Publikováno v:
Journal of medicinal chemistry. 39(5)
Ions of structure X[N(O)NO]- display broad-spectrum pharmacological activity that correlates with the rate and extent of their spontaneous, first-order decomposition to nitric oxide when dissolved. We report incorporation of this functional group int