Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mai-Yee Chan"'
Publikováno v:
Org. Biomol. Chem.. 1:123-128
The ability of 2'-alpha-C-carboxyalkyl nucleosides to undergo an unusual two-step stereocontrolled nucleobase exchange process has been investigated. Upon silylation a protected 2'-deoxy-2'-alpha-C-(carboxymethyl)uridine derivative can undergo intram
Autor:
Stephen Paul Collingwood, Robin Alec Fairhurst, Julie Fisher, Ian A. O'Neil, John Arnold, Mai-Yee Chan, Richard Cosstick
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :315-320
2′-Deoxy-2′-α-C-carboxymethyl-3′-O-tert-butyldimethylsilyl-5′-O-dimethoxytrityluridine (11a) and the corresponding 3′-deoxy derivative 2′,3′-dideoxy-2′-α-C-carboxymethyl-5′-O-dimethoxytrityluridine (11b) have been condensed with 5
Autor:
R. A. Fairhurst, John Fisher, Richard Cosstick, S. P. Collingwood, John B. J. Pavey, Mai-Yee Chan, Ian A. O'Neil, Anthony J. Lawrence
Publikováno v:
ChemInform. 29
Publikováno v:
ChemInform. 32
A novel stereo-controlled process is described which enables the uracil base on a 2′-deoxy-2′-α-C-carboxymethyluridine nucleoside to be exchanged for either a purine or another pyrimidine base, via the intermediacy of an isolable pentofuranosyl