Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mai Uesugi"'
Autor:
Patlada Suthamwong, Manabu Minami, Toshiaki Okada, Nonomi Shiwaku, Mai Uesugi, Masayuki Yokode, Kaeko Kamei
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Type 2 diabetes mellitus is characterized by insulin resistance and pancreatic β-cell dysfunction. A decrease in β-cell mass, which occurs during the progression of Type 2 diabetes mellitus, contributes to impaired insulin secre
Externí odkaz:
https://doaj.org/article/12fb102d741b41e9ac1e43c903051cba
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ead92a929cc4e895624b9120695df
https://doi.org/10.1158/1535-7163.22499889.v1
https://doi.org/10.1158/1535-7163.22499889.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 811K, Fig. S1. Effects of EPZ-6438 on Gene Promoter H3K27 Methylation, Recruitment of PRC2 Components to Gene Promoters, and Cell Cycle, in WSU-DLCL2 Cells. Fig. S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fcbfa5d3e9bdddeac3c8f600a70bce
https://doi.org/10.1158/1535-7163.22499898.v1
https://doi.org/10.1158/1535-7163.22499898.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 25K, Table S1: LCC Values for EPZ-6438 for WSU-DLCL2 Human Lymphoma Cells Dosed Either Continuously or After Compound Washout.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12304f9a85f43c2b5fe15a51c85b039b
https://doi.org/10.1158/1535-7163.22499892
https://doi.org/10.1158/1535-7163.22499892
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
Mutations within the catalytic domain of the histone methyltransferase EZH2 have been identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic alterations are hypothesized to confer an oncogenic dependency on EZH2 enzymatic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9ced2f5eb38e4c70192dc2fd63ef50
https://doi.org/10.1158/1535-7163.c.6536301
https://doi.org/10.1158/1535-7163.c.6536301
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
The list of Topologically significant genes by RNA-Seq analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b281375c38e0afca97059249be1c48
https://doi.org/10.1158/0008-5472.22427412
https://doi.org/10.1158/0008-5472.22427412
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the development of multiple types of cancer, and its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df148bb84b7d866ede93b24adb73553f
https://doi.org/10.1158/0008-5472.c.6512661.v1
https://doi.org/10.1158/0008-5472.c.6512661.v1
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
Supplementary Table S1, Table S4, Table S5, Table S6, Table S7. Supplementary Table S1: The list of DEGs by nCounter analysis (|Fold change| > 1.25, P < 0.1). Supplementary Table S4: Top 10 enriched pathways identified by RNA-Seq analysis in MMTV-Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f3891dd6ecfe611c8e93caa46647a9
https://doi.org/10.1158/0008-5472.22427409
https://doi.org/10.1158/0008-5472.22427409
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837e71997bd46c4dda72ece16272f5ee
https://doi.org/10.1158/0008-5472.22427418.v1
https://doi.org/10.1158/0008-5472.22427418.v1
Autor:
Masao Iwata, Masayuki Matsukura, Takenao Odagami, Kenichi Nomoto, Atsushi Takemura, Kenji Kubara, Hiroshi Kamiyama, Naoki Yoneda, Tomohiro Matsushima, Junji Matsui, Yuji Yamamoto, Yasuhiro Funahashi, Satoshi Inoue, Kentaro Iso, Naomi Wakayama, Atsumi Yamaguchi, Toshimitsu Uenaka, Takayuki Kimura, Kazuhiko Yamada, Akira Yokoi, Yoichi Ozawa, Masahiro Matsuki, Yusaku Hori, Takashi Owa, Hiroyuki Kouji, Junichi Ito, Ikuo Kushida, Kazutaka Nakamoto, Hitoshi Harada, Mai Uesugi, Yu Kato, Taro Semba, Akihiko Tsuruoka
Publikováno v:
Cancer Research. 81:1052-1062
The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the development of multiple types of cancer, and its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81b3cf819fdef70246e6d179d9840b3
https://doi.org/10.1158/0008-5472.can-20-0782
https://doi.org/10.1158/0008-5472.can-20-0782