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Autor:
Yuka Honda-Wakasugi, Mai Nakanou, Shigeru Maeda, Akiko Yabuki-Kawase, Minako Ishii-Maruhama, Hitoshi Higuchi, Takuya Miyawaki
Publikováno v:
Journal of anesthesia. 32(5)
It has been reported that oral valproate (VPA) reduces the dose of propofol required for sedation. As a potential reason for this, it is considered that VPA displaces serum protein-bound propofol and increases the proportion of protein-unbound-free p