Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mai Imasaka"'
Autor:
Yuichi Tsuchiya, Takao Seki, Kenta Kobayashi, Sachiko Komazawa-Sakon, Shigeyuki Shichino, Takashi Nishina, Kyoko Fukuhara, Kenichi Ikejima, Hidenari Nagai, Yoshinori Igarashi, Satoshi Ueha, Akira Oikawa, Shinya Tsurusaki, Soh Yamazaki, Chiharu Nishiyama, Tetuo Mikami, Hideo Yagita, Ko Okumura, Taketomo Kido, Atsushi Miyajima, Kouji Matsushima, Mai Imasaka, Kimi Araki, Toru Imamura, Masaki Ohmuraya, Minoru Tanaka, Hiroyasu Nakano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Liver fibrosis results from chronic liver injury triggered by factors such as viral infection, excess alcohol intake, and lipid accumulation. However, the mechanisms underlying liver fibrosis are not fully understood. Here, we demonstrate th
Externí odkaz:
https://doaj.org/article/634090b816f84d4c88ef880ddf06cc84
Autor:
Takuya Nagai, Tomohisa Sekimoto, Syuji Kurogi, Tomomi Ohta, Shihoko Miyazaki, Yoichiro Yamaguchi, Takuya Tajima, Etsuo Chosa, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Narantsog Choijookhuu, Katsuaki Sato, Yoshitaka Hishikawa, Taro Funamoto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In th
Externí odkaz:
https://doaj.org/article/0e6015e1753c41daacaf7b76f7d2d5ac
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Chronic pancreatitis (CP) is a disease characterized by the inflammation and destruction of pancreatic tissue, leading to the replacement of functional tissue with fibrotic tissue. The regenerating gene (Reg) family proteins have recently be
Externí odkaz:
https://doaj.org/article/6cf9a13a99a64b0b8d9aa92a6763e5f9
Autor:
Michio Sato, Tsuyoshi Kadomatsu, Keishi Miyata, Junco S. Warren, Zhe Tian, Shunshun Zhu, Haruki Horiguchi, Aman Makaju, Anna Bakhtina, Jun Morinaga, Taichi Sugizaki, Kaname Hirashima, Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, Yoshihiro Komohara, Tomohiko Wakayama, Shinichi Nakagawa, Sarah Franklin, Koichi Node, Kimi Araki, Yuichi Oike
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Long noncoding RNAs (lncRNAs) have been shown to play a role in cardiac physiology and disease. Here the authors identify the lncRNA Caren as a cytoplasmic RNA that decreases the translation of a distant gene encoding Hint1, thereby maintaining cardi
Externí odkaz:
https://doaj.org/article/c7569bc158f84c42902d65025ac3c85c
Autor:
Hideaki Iwama, Sally Mehanna, Mai Imasaka, Shinsuke Hashidume, Hiroshi Nishiura, Ken-ichi Yamamura, Chigure Suzuki, Yasuo Uchiyama, Etsuro Hatano, Masaki Ohmuraya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The major lysosomal proteases, Cathepsin B (CTSB), Cathepsin D (CTSD) and Cathepsin L (CTSL), are implicated in autophagic activity. To investigate the role of each cathepsin in the exocrine pancreas, we generated mice in which the pancreas
Externí odkaz:
https://doaj.org/article/7aa763c7ffb946598f69f406514abd4a
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Almost all mature cells that undergo apoptosis in an age-dependent or an accidental manner are completely recovered in tissue-specific microenvironments without any physiological changes. After peripheral blood leukocytes are released into the local
Externí odkaz:
https://doaj.org/article/82e181bbfc684abfb7aa0614812ad6c3
Autor:
Shihoko, Miyazaki, Taro, Funamoto, Tomohisa, Sekimoto, Syuji, Kurogi, Tomomi, Ohta, Takuya, Nagai, Takuya, Tajima, Mai, Imasaka, Kumiko, Yoshinobu, Kimi, Araki, Masatake, Araki, Narantsog, Choijookhuu, Yoshitaka, Hishikawa, Etsuo, Chosa
Publikováno v:
ACTA HISTOCHEMICA ET CYTOCHEMICA. 55:99-110
Epithelial protein lost in neoplasm (EPLIN) is an actin-associated cytoskeletal protein that plays an important role in epithelial cell adhesion. EPLIN has two isoforms: EPLINα and EPLINβ. In this study, we investigated the role of EPLINβ in osteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c257979ed4ecf2a52e69f05d20b255
https://doi.org/10.1267/ahc.22-00027
https://doi.org/10.1267/ahc.22-00027
Autor:
Takuma Yamamoto, Rie Sano, Aya Miura, Mai Imasaka, Yoshiro Naito, Minori Nishiguchi, Kensuke Ihara, Naruhito Otani, Yoshihiko Kominato, Masaki Ohmuraya, Hidehito Kuroyanagi, Hajime Nishio
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 100(12)
Abstract RBM20 is one of the genes predisposing to dilated cardiomyopathy (DCM). Variants in the RS domain have been reported in many DCM patients, but the pathogenicity of variants within the RNA-recognition motif remains unknown. Two human patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843ce3a71b4ce7944ca0fdca4ead4ff
https://pubmed.ncbi.nlm.nih.gov/36198914
https://pubmed.ncbi.nlm.nih.gov/36198914
Autor:
Keishi Miyata, Koichi Node, Aman Makaju, Kimi Araki, Yoshihiro Komohara, Anna Bakhtina, Taichi Sugizaki, Kumiko Yoshinobu, Zhe Tian, Kaname Hirashima, Shunshun Zhu, Sarah Franklin, Junco S. Warren, Tomohiko Wakayama, Yuichi Oike, Shinichi Nakagawa, Haruki Horiguchi, Tsuyoshi Kadomatsu, Jun Morinaga, Masatake Araki, Michio Sato, Mai Imasaka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications
Nature Communications
In the past decade, many long noncoding RNAs (lncRNAs) have been identified and their in vitro functions defined, although in some cases their functions in vivo remain less clear. Moreover, unlike nuclear lncRNAs, the roles of cytoplasmic lncRNAs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a69d3459815812a784dc1768eb66c11
https://doaj.org/article/c7569bc158f84c42902d65025ac3c85c
https://doaj.org/article/c7569bc158f84c42902d65025ac3c85c
Publikováno v:
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 22(7)
Premature intracellular trypsinogen activation has long been considered a key initiator of acute pancreatitis (AP). Cathepsin B (CTSB) activates trypsinogen, while cathepsin L (CTSL) inactivates trypsin(ogen), and both proteins play a role in the ons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f3ad54cbfac4e8c39ab016a3ec1c42
https://pubmed.ncbi.nlm.nih.gov/36038449
https://pubmed.ncbi.nlm.nih.gov/36038449