Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mai Dvorak"'
Autor:
Samantha Slight-Webb, Kevin Thomas, Miles Smith, Catriona A. Wagner, Susan Macwana, Aleksandra Bylinska, Michele Donato, Mai Dvorak, Sarah E. Chang, Alex Kuo, Peggie Cheung, Laurynas Kalesinskas, Ananthakrishnan Ganesan, Denis Dermadi, Carla J. Guthridge, Wade DeJager, Christian Wright, Mariko H. Foecke, Joan T. Merrill, Eliza Chakravarty, Cristina Arriens, Holden T. Maecker, Purvesh Khatri, Paul J. Utz, Judith A. James, Joel M. Guthridge
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomic
Externí odkaz:
https://doaj.org/article/e17965113ade415ab50fbba3c6fd56ef
Autor:
Roshani Sinha, Mai Dvorak, Ananthakrishnan Ganesan, Larry Kalesinskas, Charlotte M. Niemeyer, Christian Flotho, Kathleen M. Sakamoto, Norman Lacayo, Rachana Vinay Patil, Rhonda Perriman, Alma-Martina Cepika, Yunying Lucy Liu, Alex Kuo, Paul J. Utz, Purvesh Khatri, Alice Bertaina
Publikováno v:
Cancers, Vol 15, Iss 21, p 5204 (2023)
Juvenile myelomonocytic leukemia (JMML) is a deadly pediatric leukemia driven by RAS pathway mutations, of which >35% are gain-of-function in PTPN11. Although DNA hypermethylation portends severe clinical phenotypes, the landscape of histone modifica
Externí odkaz:
https://doaj.org/article/29ab817bcb0747f09e66a9e50ad71c86
Autor:
Lawrence Bai, Denis Dermadi, Laurynas Kalesinskas, Mai Dvorak, Sarah E Chang, Ananthakrishnan Ganesan, Samuel J S Rubin, Alex Kuo, Peggie Cheung, Michele Donato, Paul J Utz, Aida Habtezion, Purvesh Khatri
Publikováno v:
Journal of Crohn's and Colitis. 17:804-815
Background and Aims Current understanding of histone post-translational modifications [histone modifications] across immune cell types in patients with inflammatory bowel disease [IBD] during remission and flare is limited. The present study aimed to
Publikováno v:
Nature Biotechnology.
Robust benchmarking studies have highlighted how measured relative microbial abundances can vary dramatically depending on how DNA is extracted, made into libraries, sequenced, and analyzed. To build upon prior research, we investigated how sample pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d39889f4f5a2643903d6ba5a314230e
https://doi.org/10.1101/2022.09.28.509972
https://doi.org/10.1101/2022.09.28.509972
Autor:
Tal Ashuach, Bali Pulendran, Mai Dvorak, Thomas Hagan, Shankar Subramaniam, Mark M. Davis, Chunfeng Li, Nadine Rouphael, Paul J. Utz, Mario Cortese, Michele Donato, Sarah Esther Chang, Alex J. Kuo, Swati Gupta, Peggie Cheung, Steven E. Bosinger, van der Most R, Florian Wimmers, Holden T. Maecker, Purvesh Khatri, Nir Yosef, Hinton Foecke M, De Jong Se
Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we used a systems biology approach to map the epigenomic and transcriptional landscape of immunity to influenza vaccination in humans at the single-cell level. Vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf3434e97cd5a05305c4088fdce5370
https://doi.org/10.1101/2021.05.24.21253087
https://doi.org/10.1101/2021.05.24.21253087
Autor:
Sarah E. Chang, Steven Schaffert, Mai Dvorak, Aditya M Rao, Peggie Cheung, Michele Donato, Alex J. Kuo, Francesco Vallania, Paul J. Utz, Purvesh Khatri, Rong Mao
Publikováno v:
Clinical Immunology. 196:40-48
Modifications of histone proteins are fundamental to the regulation of epigenetic phenotypes. Dysregulations of histone modifications have been linked to the pathogenesis of diverse human diseases. However, identifying differential histone modificati
Autor:
Peggie Cheung, Steven E. Bosinger, Robbert van der Most, Florian Wimmers, Mariko Hinton Foecke, Michele Donato, Chunfeng Li, Sarah E. Chang, Purvesh Khatri, Nadine Rouphael, Mark M. Davis, Mai Dvorak, Shankar Subramaniam, Mario Cortese, Nir Yosef, Alex J. Kuo, Sanne E. de Jong, Tal Ashuach, Paul J. Utz, Holden T. Maecker, Shakti Gupta, Bali Pulendran, Thomas Hagan
Publikováno v:
Cell
Nature Reviews. Immunology
Nature Reviews. Immunology
Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination in humans at the single-cell level. Vaccination against seasonal influenza
Autor:
Joshua E. Elias, Claudia Macaubas, Peggie Cheung, Peter A. Nigrovic, Alexei A. Grom, Paul J. Utz, Or Gozani, Tie-Mei Li, Purvesh Khatri, Lauren A. Henderson, Michele Donato, Elizabeth D. Mellins, John P. Coan, Grant S. Schulert, Lichao Zhang, Sarah E. Chang, Steven Schaffert, Mai Dvorak, Mariko Hinton Foecke, Alex J. Kuo
Publikováno v:
Nature immunology. 22(6)
Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage development. This abundant histone mark i
Autor:
Paul J. Utz, Rachana Patil, Roshani Sinha, Kathleen M. Sakamoto, Charlotte M. Niemeyer, Alice Bertaina, Mai Dvorak, Alex J. Kuo, Y. Lucy Liu
Publikováno v:
Blood. 138:4328-4328
Juvenile myelomonocytic leukemia (JMML) is a deadly pediatric cancer characterized by excessive accumulation of monocytes/macrophages with myelodysplastic features and splenomegaly. Hematopoietic stem cell transplantation (HSCT) is the only curative