Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mai A Bailey"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0205479 (2019)
Tuberculosis is a disease of global importance for which novel drugs are urgently required. We developed a whole-cell phenotypic screen which can be used to identify inhibitors of Mycobacterium tuberculosis growth. We used recombinant strains of viru
Externí odkaz:
https://doaj.org/article/5b33e04ec36148ad939de1b7fbcf3037
Autor:
Edward A Kesicki, Mai A Bailey, Yulia Ovechkina, Julie V Early, Torey Alling, Julie Bowman, Edison S Zuniga, Suryakanta Dalai, Naresh Kumar, Thierry Masquelin, Philip A Hipskind, Joshua O Odingo, Tanya Parish
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155209 (2016)
The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity by designing and synthesizing a large number of analogs and testing these for activity aga
Externí odkaz:
https://doaj.org/article/fc563a511b4048acb7a22a45c054ad15
Autor:
Anuradha Kumar, Somsundaram Chettiar, Brian S. Brown, Julie Early, Juliane Ollinger, Megan Files, Mai A. Bailey, Aaron Korkegian, Devon Dennison, Matthew McNeil, James Metz, Augustine Osuma, Michael Curtin, Aaron Kunzer, Gail Freiberg, Milan Bruncko, Dale Kempf, Tanya Parish
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-27 (2022)
Abstract We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with anti-tuber
Externí odkaz:
https://doaj.org/article/a7bda231d18f419a8fd60f4ebad065f6
Autor:
Joshua Odingo, Julie V. Early, Suryakanta Dalai, Devon Dennison, Julie Bowman, Philip Arthur Hipskind, Tanya Parish, Jeffrey W Cramer, Thierry Masquelin, Torey Alling, Naresh Kumar, Mai A. Bailey, Megan Files
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5873-5890 (2017)
Nitazoxanide has antiparasitic and antibiotic activities including activity against Mycobacterium tuberculosis. We prepared and evaluated a set of its analogues to determine the structure–activity relationship, and identified several amide- and ure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02cfdbe8a083db56e5c2b4917b571ec
https://doaj.org/article/17e6ec56a92e416e8259d03c4b34d236
https://doaj.org/article/17e6ec56a92e416e8259d03c4b34d236
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0205479 (2019)
PLoS ONE
PLoS ONE
Tuberculosis is a disease of global importance for which novel drugs are urgently required. We developed a whole-cell phenotypic screen which can be used to identify inhibitors of Mycobacterium tuberculosis growth. We used recombinant strains of viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd26b9508871883dc441db24b954e36
https://doaj.org/article/5b33e04ec36148ad939de1b7fbcf3037
https://doaj.org/article/5b33e04ec36148ad939de1b7fbcf3037
Autor:
Joshua O, Odingo, Julie V, Early, Jake, Smith, James, Johnson, Mai A, Bailey, Megan, Files, Junitta, Guzman, Juliane, Ollinger, Aaron, Korkegian, Anuradha, Kumar, Yulia, Ovechkina, Tanya, Parish
Publikováno v:
Drug Development Research
There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8‐hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities. We condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f94ff83db2bcd1fa8d50f76a41dd9e9
https://pubmed.ncbi.nlm.nih.gov/30893501
https://pubmed.ncbi.nlm.nih.gov/30893501
Autor:
Mai A. Bailey, Maria Angeles Martinez-Grau, Yulia Ovechkina, Allen Casey, Tanya Parish, Isabel C. Gonzalez Valcarcel, Torey Alling, Juliane Ollinger, Michal Vieth, Megan Files, Julie V. Early
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:3608-3616
Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran a phenotypic screen using butyrate as the sole carbon so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b15ab5c46fbfc7b9a62b9bcc568fc4
https://doi.org/10.1128/aac.02896-15
https://doi.org/10.1128/aac.02896-15
Autor:
Tanya Parish, David B. Olsen, Mai A. Bailey, Aaron Korkegian, Katherine Young, Theresa O’Malley, Bjorn Sunde, Sheo B. Singh, Yulia Ovechkina, James C. Sacchettini, Thomas R. Ioerger, Joshua Odingo
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
Objective Our aim was to identify natural products with anti-tubercular activity. Results A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d485e600d89c8844cd774e8dc7679c5
http://europepmc.org/articles/PMC6022709
http://europepmc.org/articles/PMC6022709
Autor:
Garrett C. Moraski, Jeffrey R. Anderson, Scott G. Franzblau, Surafel Mulugeta, Patricia A. Miller, Sang-Hyun Cho, Marvin J. Miller, Tanya Parish, Juliane Ollinger, Helena I. Boshoff, Mai A. Bailey
Publikováno v:
ACS Infectious Diseases
Zolpidem (Ambien, 1) is an imidazo[1,2-a]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec16381190fcb3db8f8685900b151fca
https://doi.org/10.1021/id500008t
https://doi.org/10.1021/id500008t
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0184107 (2017)
PLoS ONE
PLoS ONE
Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa6c60964ffeee974576a9d8a4c504e
http://europepmc.org/articles/PMC5574600?pdf=render
http://europepmc.org/articles/PMC5574600?pdf=render