Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Mahua Dey"'
Autor:
Sudarshawn Damodharan, Jack M. Shireman, Elliot Xie, Emily Distler, Christina Kendziorski, Mahua Dey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Diffuse midline glioma, H3 K27-altered (DMG) are highly aggressive malignancies of the central nervous system (CNS) that primarily affect the pediatric population. Large scale spatial transcriptomic studies have implicated that tumor microen
Externí odkaz:
https://doaj.org/article/c66719fe1c1c47af9c7b1eaff611319a
Autor:
Jack M. Shireman, Quinn White, Zijian Ni, Chitrasen Mohanty, Yujia Cai, Lei Zhao, Namita Agrawal, Nikita Gonugunta, Xiaohu Wang, Liam Mccarthy, Varshitha Kasulabada, Akshita Pattnaik, Atique U. Ahmed, James Miller, Charles Kulwin, Aaron Cohen-Gadol, Troy Payner, Chih-Ta Lin, Jesse J. Savage, Brandon Lane, Kevin Shiue, Aaron Kamer, Mitesh Shah, Gopal Iyer, Gordon Watson, Christina Kendziorski, Mahua Dey
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109601- (2024)
Summary: Stereotactic radiosurgery (SRS) has been shown to be efficacious for the treatment of limited brain metastasis (BM); however, the effects of SRS on human brain metastases have yet to be studied. We performed genomic analysis on resected brai
Externí odkaz:
https://doaj.org/article/828ec409f6884148a8d4d17d849d56c6
Autor:
Jack M. Shireman, Lingxin Cheng, Amiti Goel, Diogo Moniz Garcia, Sanil Partha, Alfredo Quiñones-Hinojosa, Christina Kendziorski, Mahua Dey
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This te
Externí odkaz:
https://doaj.org/article/f4f8d78bcd6644b4a875683e92ef2310
Autor:
Dana Mitchell, Jack Shireman, Elizabeth A. Sierra Potchanant, Montserrat Lara-Velazquez, Mahua Dey
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
According to classical dogma, the central nervous system (CNS) is defined as an immune privileged space. The basis of this theory was rooted in an incomplete understanding of the CNS microenvironment, however, recent advances such as the identificati
Externí odkaz:
https://doaj.org/article/924bdb095d08458f980c13b089d48351
Autor:
Montserrat Lara-Velazquez, Jack M. Shireman, Eric J. Lehrer, Kelsey M. Bowman, Henry Ruiz-Garcia, Mitchell J. Paukner, Richard J. Chappell, Mahua Dey
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundImmunotherapy for GBM is an emerging field which is increasingly being investigated in combination with standard of care treatment options with variable reported success rates.ObjectiveTo perform a systematic review of the available data to
Externí odkaz:
https://doaj.org/article/11e2725c11c44074807e6235d50338bd
Autor:
Wei X. Huff, Namita Agrawal, Scott Shapiro, James Miller, Charles Kulwin, Mitesh Shah, Jesse J. Savage, Troy Payner, Alexander Vortmeyer, Gordon Watson, Mahua Dey
Publikováno v:
Radiation Oncology, Vol 13, Iss 1, Pp 1-10 (2018)
Abstract Background Stereotactic radiosurgery (SRS) has emerged as a common adjuvant modality used with surgery for resectable brain metastases (BMs). However, the optimal sequence of the multi-modality therapy has not been established. The goal of t
Externí odkaz:
https://doaj.org/article/450dded1c262405eaacbdde8acc354b0
Autor:
Dana Mitchell, Sreenivasulu Chintala, Kaleigh Fetcko, Mario Henriquez, Brij N. Tewari, Atique Ahmed, R. Timothy Bentley, Mahua Dey
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Spontaneous canine (Canis lupus) oligodendroglioma (ODG) holds tremendous potential as an immunocompetent large animal model of human malignant gliomas (MG). However, the feasibility of utilizing this model in pre-clinical studies depends on a thorou
Externí odkaz:
https://doaj.org/article/e9e6773938c0429d8183b6fcc0fb2971
Autor:
Mahua Dey, Dou Yu, Deepak Kanojia, Gina Li, Madina Sukhanova, Drew A. Spencer, Katatzyna C. Pituch, Lingjiao Zhang, Yu Han, Atique U. Ahmed, Karen S. Aboody, Maciej S. Lesniak, Irina V. Balyasnikova
Publikováno v:
Stem Cell Reports, Vol 7, Iss 3, Pp 471-482 (2016)
The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes
Externí odkaz:
https://doaj.org/article/b2cde89db5274a6281ea039579ed39fc
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
T cell chimeric antigen receptor (CAR) technology has allowed for the introduction of a high degree of tumor selectivity into adoptive cell transfer therapies. Evolution of this technology has produced a robust antitumor immunotherapeutic strategy th
Externí odkaz:
https://doaj.org/article/0cf2ef55cbcd4a248c4c5f454272e7df
Autor:
Anna C. Filley, Mahua Dey
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to selectively infect, replicate in, and lyse malignant cells without causing harm to normal, healthy tissues. In addition to direct oncolytic activity, OVs have
Externí odkaz:
https://doaj.org/article/ef27e85101754e04b3fd6e49d259fc92