Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Mahtab Moayeri"'
Autor:
Ankur Bothra, Megan L. Perry, Elena Wei, Mahtab Moayeri, Qian Ma, Marco A. Biamonte, Marina Siirin, Stephen H. Leppla
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The detection of pathogens is critical for clinical diagnosis and public health surveillance. Detection is usually done with nucleic acid-based tests (NATs) and rapid antigen tests (e.g., lateral flow assays [LFAs]). Although NATs are more s
Externí odkaz:
https://doaj.org/article/032703192eb744d6b0f9fa2fdb9cf55a
Autor:
Caio C. B. Bomfim, Logan Fisher, Eduardo P. Amaral, Lara Mittereder, Katelyn McCann, André A. S. Correa, Sivaranjani Namasivayam, Muthulekha Swamydas, Mahtab Moayeri, Jonathan M. Weiss, Raj Chari, Daniel W. McVicar, Diego L. Costa, Maria R. D’Império Lima, Alan Sher
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in Mycob
Externí odkaz:
https://doaj.org/article/829c533eabff4b7a98e063262dae07c5
Publikováno v:
Innate Immunity, Vol 26 (2020)
Inflammasomes act as sensors of infection or damage to initiate immune responses. While extensively studied in rodents, understanding of livestock inflammasomes is limited. The NLRP1 inflammasome sensor in rodents is activated by Toxoplasma gondii ,
Externí odkaz:
https://doaj.org/article/7b19d86c1cc34d338a1536ddf9940896
Autor:
Dante A. Suffredini, Xizhong Cui, Dharmvir Jaswal, Kenneth E. Remy, Yan Li, Junfeng Sun, Steven B. Solomon, Yvonne Fitz, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker
Publikováno v:
Intensive Care Medicine Experimental, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract Background Although anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for B. anthracis toxin-associated shock
Externí odkaz:
https://doaj.org/article/fc1405e36eec411aac3a8e7cf8c16967
Autor:
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Jian Sha, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectively, are two of the deadliest pathogenic bacteria that have been used as biological warfare agents. Although Biothrax is a licensed vaccine against
Externí odkaz:
https://doaj.org/article/8e99a89944ec4a70998d621b245a3deb
Publikováno v:
Toxins, Vol 13, Iss 1, p 53 (2021)
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support. Both of these standard therapies could negate
Externí odkaz:
https://doaj.org/article/96e5290c981b4200932a54068d91f8d2
Autor:
Eduardo P. Amaral, Nicolas Riteau, Mahtab Moayeri, Nolan Maier, Katrin D. Mayer-Barber, Rosana M. Pereira, Silvia L. Lage, Andre Kubler, William R. Bishai, Maria R. D’Império-Lima, Alan Sher, Bruno B. Andrade
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for NLRP3-inflammasome assembly and, consequently, for mature IL-1β gene
Externí odkaz:
https://doaj.org/article/05a9b43a81de41989607b87fe438516b
Autor:
Annabel Guichard, Prashant Jain, Mahtab Moayeri, Ruth Schwartz, Stephen Chin, Lin Zhu, Beatriz Cruz-Moreno, Janet Z Liu, Bernice Aguilar, Andrew Hollands, Stephen H Leppla, Victor Nizet, Ethan Bier
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006603 (2017)
Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As
Externí odkaz:
https://doaj.org/article/7da69dcd7e13456c9f96af4371105fec
Autor:
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Michelle L. Kirtley, Eric C. Fitts, Jourdan A. Andersson, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Bioterrorism remains as one of the biggest challenges to global security and public health. Since the deadly anthrax attacks of 2001 in the United States, Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague, respectivel
Externí odkaz:
https://doaj.org/article/8a34650f189348629f8a72016ea0aada
Autor:
Laurence Abrami, Lucia Brandi, Mahtab Moayeri, Michael J. Brown, Bryan A. Krantz, Stephen H. Leppla, F. Gisou van der Goot
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 986-996 (2013)
Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA forms a channel that translocates LF, not only into the cytosol, but a
Externí odkaz:
https://doaj.org/article/d43dcacd9a7043f9b4c4b58ad2e2bd10