Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mahsa Sorouri"'
Autor:
Tyron Chang, Jessica Alvarez, Sruthi Chappidi, Stacey Crockett, Mahsa Sorouri, Robert C Orchard, Dustin C Hancks
Publikováno v:
PLoS Pathogens, Vol 20, Iss 10, p e1012673 (2024)
Interferon (IFN) induced activities are critical, early determinants of immune responses and infection outcomes. A key facet of IFN responses is the upregulation of hundreds of mRNAs termed interferon-stimulated genes (ISGs) that activate intrinsic a
Externí odkaz:
https://doaj.org/article/1b7bf45041b848df9e780c332c3aa961
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Mitochondria are dynamic organelles vital for energy production with now appreciated roles in immune defense. During microbial infection, mitochondria serve as signaling hubs to induce immune responses to counteract invading pathogens like v
Externí odkaz:
https://doaj.org/article/0777ad48a4f34ed693057e08842c37a6
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001045 (2020)
Host-pathogen conflicts leave genetic signatures in genes that are critical for host defense functions. Using these "molecular scars" as a guide to discover gene functions, we discovered a vertebrate-specific MItochondrial STress Response (MISTR) cir
Externí odkaz:
https://doaj.org/article/a76503ce87044219915bec7c1096992e
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106699 (2014)
Monoclonal antibodies are important tools in research and since the 1990s have been an important therapeutic class targeting a wide variety of diseases. Earlier methods of mAb production relied exclusively on the lengthy process of making hybridomas.
Externí odkaz:
https://doaj.org/article/81542b1db53c4071bc00d813cad542b5
Autor:
J. William Harbour, Stefan Kurtenbach, Margaret Sanchez, Jeffim Kuznetsoff, Daniel Rodriguez, Natalia Weich, James Dollar, Anthony Cruz, Sarah Kurtenbach, Matthew Field, Christina Decatur, Mahsa Sorouri, Fan Lai, Ramin Shiekhattar, Daniel Pelaez, Zelia Correa, Ramiro Verdun
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in spermato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f5be9eae333c1ad3d4acd8c094e1abb
https://doi.org/10.21203/rs.3.rs-2861359/v1
https://doi.org/10.21203/rs.3.rs-2861359/v1
Autor:
Mahsa Sorouri, Tyron Chang, Palmy Jesudhasan, Chelsea Pinkham, Nels C. Elde, Dustin C. Hancks
Host-pathogen conflicts leave genetic signatures of variation in homologous host genes. Using these “molecular scars” as a guide, we discovered a vertebrate-specific MItochondrial STress Response circuit (MISTR). MISTR proteins are associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c373fb35ea888fed9f133b714814875
Autor:
Hao Zhu, Jen Chieh Chuang, Shuyuan Zhang, Meng Wu, Zhong Wang, Liem H. Nguyen, Jian Xu, Linwei Wu, Chao Xing, Lin Li, Robert A.J. Signer, Yong Zhao, Thomas Maples, Yi Chun Kuo, Mahsa Sorouri, Xin Liu, Sam C. Wang, Ibrahim Nassour, Cemre Celen, Mohammed Kanchwala, Hanquan Liang, Xuxu Sun
Publikováno v:
Cell Stem Cell. 18:456-466
Mammals have partially lost the extensive regenerative capabilities of some vertebrates, possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. Here, we show that deleting the SWI/SNF component Arid1a substanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ddd6d6334260394f4a94f49669db50
https://doi.org/10.1016/j.stem.2016.03.001
https://doi.org/10.1016/j.stem.2016.03.001
Publikováno v:
The Journal of Immunology. 204:226.11-226.11
While the identities of many interferon-stimulated genes (ISGs) are established, the functions of the majority of these gene products as well as their relationship with other cellular factors are unknown. To drive functional characterization, we soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66037ffbd099da40163a2b30c789f486
https://doi.org/10.4049/jimmunol.204.supp.226.11
https://doi.org/10.4049/jimmunol.204.supp.226.11
Autor:
Malcolm MacConmara, Xin Luo, Mahsa Sorouri, Hao Zhu, Veronica Renteria, Tao Wang, Mobolaji Odewole, Younghoon Jang, Purva Gopal, Amit G. Singal, Adam C. Yopp, Yuemeng Jia, Min Zhu, Justin R. Parekh, Lin Li, Tianshi Lu, Kai Ge, Sam C. Wang
Publikováno v:
Cell. 177:608-621.e12
Summary Normal tissues accumulate genetic changes with age, but it is unknown if somatic mutations promote clonal expansion of non-malignant cells in the setting of chronic degenerative diseases. Exome sequencing of diseased liver samples from 82 pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59815541aaacccfdd71decf75c1e6eba
https://doi.org/10.1016/j.cell.2019.03.026
https://doi.org/10.1016/j.cell.2019.03.026
Autor:
Thomas Maples, Sam C. Wang, Mahsa Sorouri, Min Zhu, Shunjun Fu, Zixi Wang, Tae Hyun Hwang, Jen Chieh Chuang, Hao Zhu, Lin Li, Shuyuan Zhang, Amit G. Singal, Yuemeng Jia, Cemre Celen, Liem H. Nguyen, Yonglong Wei, Xuxu Sun, Laura P. James, Adam C. Yopp, Lijian Hui, Yuan Ji, Weiping Li, Lynda Letzig, Ibrahim Nassour, Linwei Wu, Xin Luo, Purva Gopal, Feng Tian
Publikováno v:
Cancer cell. 32(5)
ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients, ARID1A was highly expressed in primary tumors but not in metastatic lesions, suggesting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bea20e247bf1466ddd8b7bfbcadaf0
https://pubmed.ncbi.nlm.nih.gov/29316428
https://pubmed.ncbi.nlm.nih.gov/29316428