Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mahsa Rouhanizadeh"'
Autor:
Tzung K. Hsiai, Rongsong Li, Jeffrey Cui, Wakako Takabe, Martin A. Gundersen, Lisong Ai, Pin Wang, Tyler Beebe, Mahsa Rouhanizadeh
Publikováno v:
Biochemical and Biophysical Research Communications. 388:406-412
Mitochondrial dysfunction is intimately involved in cardiovascular diseases. Mitochondrial membrane potential (DeltaPsi(m)) is coupled with oxidative phosphorylation to drive ATP synthesis. In this study, we examined the effect of physiological pulsa
Publikováno v:
Journal of Microelectromechanical Systems. 17:1178-1186
Hemodynamic forces, specifically fluid shear stress, play an important role in the focal nature of arterial plaque formation known as atherosclerosis. We hereby developed biocompatible and flexible intravascular microelectromechanical systems sensor
Autor:
Ryan T. Hamilton, Mahsa Rouhanizadeh, Tzung K. Hsiai, Juliana Hwang, Adria Correa, Mark L. Barr, Enrique Cadenas, Mohammad Alavi, Stanley L. Hazen
Publikováno v:
Free Radical Biology and Medicine. 42:519-529
Hemodynamics, specifically, fluid shear stress, modulates the focal nature of atherogenesis. Superoxide anion (O2(-.)) reacts with nitric oxide (.NO) at a rapid diffusion-limited rate to form peroxynitrite (O2(-.) + .NO-->ONOO(-)). Immunohistostainin
Autor:
Mahsa Rouhanizadeh, Ryan T. Hamilton, Howard N. Hodis, Tiantian Lin, Jason P. Eiserich, Juliana Hwang, Tzung K. Hsiai
Publikováno v:
Free Radical Biology and Medicine. 41:568-578
Within arterial bifurcations or branching points, oscillatory shear stress (OSS) induces oxidative stress mainly via the reduced nicotinamide adenine dinucleodtide phosphate (NADPH) oxidase system. It is unknown whether 17β-estradiol (E2) can regula
Publikováno v:
Sensors and Actuators B: Chemical. 114:788-798
Oxidized low density lipoprotein (oxLDL) is considered a biomarker for acute heart attack in patients with coronary artery disease (CAD). LDL cholesterol in the circulatory system can undergo oxidative modification to oxidized LDL (oxLDL), leading to
Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells
Autor:
Tzung K. Hsiai, Mahsa Rouhanizadeh, Srinivasa T. Reddy, Lucas DeMaio, Alex Sevanian, Juliana Hwang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H674-H683
Oxidized l-α-1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine (OxPAPC), a component of minimally modified LDL, induces production of proinflammatory cytokines and development of atherosclerotic lesions. We tested the hypothesis that OxPAPC
Autor:
Gopikrishnan Soundararajan, Tzung K. Hsiai, R. Lo, Mahsa Rouhanizadeh, F.K. Browand, Diego Arcas
Publikováno v:
IEEE Sensors Journal. 6:78-88
Coronary artery disease (CAD) preferentially develops at the arterial branching points or bifurcations. Hemodynamics, particularly wall shear stress, plays an important role in regulating the development of CAD. The advent of the microelectromechanic
Autor:
Juliana Hwang, Bernard Lassègue, Tzung K. Hsiai, Alex Sevanian, Laura Marcu, Roza E. Clempus, Mahsa Rouhanizadeh
Publikováno v:
Free Radical Biology and Medicine. 39:1512-1522
Modified low-density lipoprotein (LDL) induces reactive oxygen species (ROS) production by vascular cells. It is unknown if specific oxidized components in these LDL particles such as oxidized-1-palmitoyl-2-arachidonoyl- sn -glycero-3-phosphorylcholi
Publikováno v:
Annals of Biomedical Engineering. 33:1360-1374
Real-time wall shear stress is difficult to monitor precisely because it varies in space and time. Microelectromechanical systems sensor provides high spatial resolution to resolve variations in shear stress in a 3-D bifurcation model for small-scale
Autor:
Gopikrishnan Soundararajan, Tzung K. Hsiai, Hongyu Yu, Lucas DeMaio, Mahsa Rouhanizadeh, Eun Sok Kim
Publikováno v:
Sensors and Actuators A: Physical. 118:25-32
Coronary artery disease is the leading cause of morbidity and mortality in the industrialized nations. Both biochemical and biomechanical stimuli modulate the pathogenesis of coronary artery diseases. Shear stress acting on the lumen of blood vessels