Development of mineralogy-based approaches to study the loss of copper minerals into tailings of scavenger flotation circuit – Part I

Autor: Ataallah Bahrami, Mahsa Rahbari, Fatemeh Kazemi, Mirsaleh Mirmohammadi, Abolfazl Danesh

Publikováno v: International Journal of Mining and Geo-Engineering, Vol 58, Iss 1, Pp 21-30 (2024)

Loss of copper minerals to tailings of the rougher and scavenger circuits is one of the challenges in copper concentration plants, which reduces the efficiency of the circuit. The goal of this research is to utilize mineralogy-based techniques to ide

Externí odkaz: https://doaj.org/article/a786f7e3be2648f5aeced5379b319fa2

Arylmethylamino steroids as antiparasitic agents

Autor: Reimar Krieg, Esther Jortzik, Alice-Anne Goetz, Stéphanie Blandin, Sergio Wittlin, Mourad Elhabiri, Mahsa Rahbari, Selbi Nuryyeva, Kerstin Voigt, Hans-Martin Dahse, Axel Brakhage, Svenja Beckmann, Thomas Quack, Christoph G. Grevelding, Anthony B. Pinkerton, Bruno Schönecker, Jeremy Burrows, Elisabeth Davioud-Charvet, Stefan Rahlfs, Katja Becker

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide

Externí odkaz: https://doaj.org/article/00677fe185ed4193bb6f7cdfdfcd60a9

H2O2 dynamics in the malaria parasite Plasmodium falciparum.

Autor: Mahsa Rahbari, Stefan Rahlfs, Esther Jortzik, Ivan Bogeski, Katja Becker

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174837 (2017)

Hydrogen peroxide is an important antimicrobial agent but is also crucially involved in redox signaling and pathogen-host cell interactions. As a basis for systematically investigating intracellular H2O2 dynamics and regulation in living malaria para

Externí odkaz: https://doaj.org/article/3e8a3e200be24ff19cce77e11c524990

Stable Integration and Comparison of hGrx1-roGFP2 and sfroGFP2 Redox Probes in the Malaria Parasite Plasmodium falciparum

Autor: Stefan Rahlfs, Anna Katharina Schuh, Franziska Mohring, Stine Weder, Katja Becker, Stanislaw J. Gabryszewski, Mahsa Rahbari, Kathrin Buchholz, David A. Fidock, Kim C. Heimsch

Studying redox metabolism in malaria parasites is of great interest for understanding parasite biology, parasite-host interactions, and mechanisms of drug action. Genetically encoded fluorescent redox sensors have recently been described as powerful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521f573cbfc08ac11e6b4ffc7844618a
https://europepmc.org/articles/PMC6402873/

Author Correction: Arylmethylamino steroids as antiparasitic agents

Autor: Anthony B. Pinkerton, Mourad Elhabiri, Reimar Krieg, Katja Becker, Esther Jortzik, Kerstin Voigt, Alice-Anne Goetz, Stefan Rahlfs, Sergio Wittlin, Bruno Schönecker, Hans-Martin Dahse, Svenja Beckmann, Thomas Quack, Axel A. Brakhage, Jeremy N. Burrows, Selbi Nuryyeva, Stéphanie Blandin, Elisabeth Davioud-Charvet, Christoph G. Grevelding, Mahsa Rahbari

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11018-x⟩

In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232d380a76d448b9e19bf7c3e746ead0
https://doaj.org/article/94072e21d7df445db92533cf466fed4f