Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mahrokh Nohadani"'
Publikováno v:
Iranian Journal of Pathology, Vol 14, Iss 2, Pp 113-121 (2019)
Iranian Journal of Pathology
Iranian Journal of Pathology
Background and Objective: Anti-CK5/6 monoclonal antibodies have an established role in breast disease diagnosis. Anti-CK5 monoclonal antibodies have recently become commercially available. There has been growing interest in the staining characteristi
Autor:
Mahrokh Nohadani, Lina Chen, Ioannis Assiotis, Iwanka Kozarewa, Zakaria Eltahir, Alina Lemnrau, M. Benson, Louise J. Barber, Christopher J. Lord, Ian Chau, David Gonzalez-de-Castro, Naureen Starling, Irene Chong, David Cunningham, Gordon Stamp, Sebastian Guettler, Isaac Garcia-Murillas, Andrew Wotherspoon, James Campbell, Alan Ashworth, Kerry Fenwick, Nick Orr, Sheela Rao, Sanna Hulkki, Maryou B. Lambros, Saima Awan
Publikováno v:
The Journal of Pathology. 231:301-310
The incidence of oesophagogastric junctional (OGJ) adenocarcinoma is rising rapidly in western countries, in contrast to the declining frequency of distal gastric carcinoma. Treatment options for adenocarcinomas involving the oesophagogastric junctio
Autor:
Gordon Stamp, Joost van den Oord, James Larkin, Anna Carlisle, Dirk C. Strauss, Richard Marais, Simon J. Furney, Mahrokh Nohadani, J. Meirion Thomas, Andrew J. Hayes, Samra Turajlic, Martin Gore
Publikováno v:
The Journal of Pathology. 230:261-269
Mucosal melanoma displays distinct clinical and epidemiological features compared to cutaneous melanoma. Here we used whole genome and whole exome sequencing to characterize the somatic alterations and mutation spectra in the genomes of ten mucosal m
Autor:
Gordon Stamp, Andrew Rowan, Claudio R. Santos, Bradley Spencer-Dene, Aron Charles Eklund, Adam Butler, Patrick S. Tarpey, Lisa Pickering, Nicholas Matthews, Stuart Horswell, Calli Latimer, Julian Downward, James Larkin, Neil Q. McDonald, Aengus Stewart, Zoltan Szallasi, Marco Gerlinger, David Endesfelder, David T. Jones, Martin Gore, Graham Clark, Keiran Raine, P. Andrew Futreal, Sharmin Begum, Eva Grönroos, Ignacio Varela, Charles Swanton, Pierre Martinez, Benjamin Phillimore, Mahrokh Nohadani
Publikováno v:
New England Journal of Medicine. 366:883-892
Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. Methods To examine intratumor heterogeneity, we performed exome sequenc
Autor:
Vikash Reebye, Mahrokh Nohadani, Charlotte L. Bevan, Amin Hajitou, Paul J. Mintz, Nagy A. Habib
Publikováno v:
Cellular Signalling. 22:1874-1881
The underlying mechanism of failed androgen ablation therapy is unknown. It is recognised that under therapeutic conditions the androgen receptor (AR) remains functionally active independent of hormone stimulation and may function through an alternat
Autor:
Annelies S. Zinkernagel, Gordon Stamp, Robert Edwards, Ioanna Tziona, Mahrokh Nohadani, Victor Nizet, Shiranee Sriskandan, Richard A. Lawrenson, Claire E. Turner, Faraz M. Alam, Prathiba Kurupati
Publikováno v:
Molecular Microbiology. 76:1387-1397
Summary SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection i
Autor:
Motoi Ohba, Joseph J. Boyle, Dorian O. Haskard, Olivier A. Harari, Justin C. Mason, Elaine A. Lidington, Allen M. Samarel, Mahrokh Nohadani, R. Steinberg
Publikováno v:
Journal of Biological Chemistry. 282:32288-32297
Endothelial cell apoptosis is associated with vascular injury and predisposes to atherogenesis. Endothelial cells express anti-apoptotic genes including Bcl-2, Bcl-XL and survivin, which also contribute to angiogenesis and vascular remodeling. We rep
Autor:
Irene Y, Chong, David, Cunningham, Louise J, Barber, James, Campbell, Lina, Chen, Iwanka, Kozarewa, Kerry, Fenwick, Ioannis, Assiotis, Sebastian, Guettler, Isaac, Garcia-Murillas, Saima, Awan, Maryou, Lambros, Naureen, Starling, Andrew, Wotherspoon, Gordon, Stamp, David, Gonzalez-de-Castro, Martin, Benson, Ian, Chau, Sanna, Hulkki, Mahrokh, Nohadani, Zakaria, Eltahir, Alina, Lemnrau, Nicholas, Orr, Sheela, Rao, Christopher J, Lord, Alan, Ashworth
Publikováno v:
The Journal of pathology. 231(3)
The incidence of oesophagogastric junctional (OGJ) adenocarcinoma is rising rapidly in western countries, in contrast to the declining frequency of distal gastric carcinoma. Treatment options for adenocarcinomas involving the oesophagogastric junctio
Autor:
Simon J, Furney, Samra, Turajlic, Gordon, Stamp, Mahrokh, Nohadani, Anna, Carlisle, J Meirion, Thomas, Andrew, Hayes, Dirk, Strauss, Martin, Gore, Joost, van den Oord, James, Larkin, Richard, Marais
Publikováno v:
The Journal of pathology. 230(3)
Mucosal melanoma displays distinct clinical and epidemiological features compared to cutaneous melanoma. Here we used whole genome and whole exome sequencing to characterize the somatic alterations and mutation spectra in the genomes of ten mucosal m
Autor:
Dulcie V. Coleman, Mark C. Poznansky, Fatimah Jaafar, Roberto Dina, Christine Linton, Tyler Lloyd, Mahrokh Nohadani, Elda Righi, Victoria Lindstrom, Joshua Poznansky, Gordon Stamp, Susan Van Noorden
Publikováno v:
The American journal of pathology. 175(4)
Human cervical cancer is an immunogenic tumor with a defined pattern of histopathological and clinical progression. Tumor-infiltrating T cells contribute to immune control of this tumor; however, cervical cancer dysregulates this immune response both