Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Maho Niwa"'
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113403- (2023)
Summary: The inheritance of a functional endoplasmic reticulum (ER) is ensured by the ER stress surveillance (ERSU) pathway. Here, we made the unexpected discovery that reticulon 1 (Rtn1) and Yop1, well-known ER-curvature-generating proteins, each po
Externí odkaz:
https://doaj.org/article/334a0eba7c3e420495d212c293fcb29d
Autor:
Barun Das, Kevin Okamoto, John Rabalais, Ronald R. Marchelletta, Kim E. Barrett, Soumita Das, Maho Niwa, Mamata Sivagnanam
Publikováno v:
Cells, Vol 9, Iss 4, p 946 (2020)
Congenital tufting enteropathy (CTE) is a rare chronic diarrheal disease of infancy caused by mutations in epithelial cell adhesion molecule (EpCAM). Previously, a murine CTE model showed mis-localization of EpCAM away from the basolateral cell surfa
Externí odkaz:
https://doaj.org/article/3dbb270ff7f54b17916142b6701171e3
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 850-858 (2014)
An evolutionarily conserved unfolded protein response (UPR) component, IRE1, cleaves XBP1/HAC1 introns in order to generate spliced mRNAs that are translated into potent transcription factors. IRE1 also cleaves endoplasmic-reticulum-associated RNAs l
Externí odkaz:
https://doaj.org/article/023a6101a55543ddbe2233b08cc9c1e3
Autor:
Francisco J Piña, Maho Niwa
Publikováno v:
eLife, Vol 4 (2015)
Stress induced by cytoplasmic protein aggregates can have deleterious consequences for the cell, contributing to neurodegeneration and other diseases. Protein aggregates are also formed within the endoplasmic reticulum (ER), although the fate of ER p
Externí odkaz:
https://doaj.org/article/0519e19c86304bb683f7ad93d025cedb
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45078 (2012)
NF-κB, a transcription factor, becomes activated during the Unfolded Protein Response (UPR), an endoplasmic reticulum (ER) stress response pathway. NF-κB is normally held inactive by its inhibitor, IκBα. Multiple cellular pathways activate IKK (I
Externí odkaz:
https://doaj.org/article/280dba229211443d82c3c5b0f8f3ba81
Autor:
Albert C. Koong, Maho Niwa, Quynh-Thu Le, Amato J. Giaccia, Nicholas C. Denko, Pek Y. Lum, David E. Solow-Cordero, Margaret M. Kozak, Aparna Gupta, Michael P. Hay, Muthuraman Alagappan, Arvin B. Tam, Dadi Jiang
The Supplementary Material contains additional characterization for the compounds mentioned in the paper. We have provided melting point, 1H NMR and low resolution mass spectrometry data as well as HPLC purity for these known compounds. We have also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a22946057ba1e4e044375218054437
https://doi.org/10.1158/1535-7163.22503138.v1
https://doi.org/10.1158/1535-7163.22503138.v1
Autor:
Dollie LaJoie, Ayse M. Turkmen, Douglas R. Mackay, Christopher C. Jensen, Vasilisa Aksenova, Maho Niwa, Mary Dasso, Katharine S. Ullman
Assembly of the nucleus following mitosis requires rapid and coordinate recruitment of diverse constituents to the inner nuclear membrane. We have identified an unexpected role for the nucleoporin Nup153 in promoting the continued addition of a subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4094db2c9d8b64a46c00efc71ea5f06
https://doi.org/10.1101/2022.05.27.493435
https://doi.org/10.1101/2022.05.27.493435
Publikováno v:
Molecular biology of the cell. 32(2)
The endoplasmic reticulum (ER) is one of the largest cytoplasmic organelles in eukaryotic cells and plays a role in many cellular processes, such as the production and quality control of secretory protein, lipid synthesis, and calcium homeostasis. Th
Publikováno v:
SSRN Electronic Journal.
Autor:
James L. Mueller, Andrew Beppu, Peter Rosenthal, David H. Broide, Hal M. Hoffman, Marina Miller, Arvin B. Tam, Maho Niwa, Christine Vuong, Ruth Gordillo, Matthew D. McGeough, Taylor A. Doherty
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 198, iss 8
In this study, we used cre-lox techniques to generate mice selectively deficient in ORMDL3 in airway epithelium (Ormdl3Δ2-3/Δ2-3/CC10) to simulate an inhaled therapy that effectively inhibited ORMDL3 expression in the airway. In contrast to the ant