Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mahnoush Bahjat"'
Autor:
Renate M. Hoogeveen, Simone L. Verweij, Jeffrey Kroon, Johan G. Schnitzler, Arjen J. Cupido, Mahnoush Bahjat, Lotte C.A. Stiekema, Erik S.G. Stroes, Sotirios Tsimikas, Kim E. Dzobo, Koen H.M. Prange, Menno P.J. de Winther
Publikováno v:
European heart journal, vol 41, iss 24
European heart journal, 41(24), 2262-2271. Oxford University Press
European heart journal, 41(24), 2262-2271. Oxford University Press
Aims Elevated lipoprotein(a) [Lp(a)] is strongly associated with an increased cardiovascular disease (CVD) risk. We previously reported that pro-inflammatory activation of circulating monocytes is a potential mechanism by which Lp(a) mediates CVD. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06540fe5347f3b6185d5d7a2106715d
http://www.scopus.com/inward/record.url?scp=85088536364&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85088536364&partnerID=8YFLogxK
Autor:
Guus de Wilde, Tijmen P. van Dam, Timon A. Bloedjes, Mahnoush Bahjat, Carel J. M. van Noesel, Marie José Kersten, Jeroen E. J. Guikema, Eric Eldering, Chiel Maas, Dieuwertje M. Luijks, Richard J. Bende
Publikováno v:
Cell cycle (Georgetown, Tex.), 18(18), 2307-2322. Landes Bioscience
Cell Cycle
Cell Cycle
The BCR-ABL1 fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) targeting the ABL kinase (such as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fc0d7a3c752fee125b1960123c29c5
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071067840&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071067840&origin=inward
Autor:
Ioana Nicorescu, Erik S.G. Stroes, Menno P.J. de Winther, Mahnoush Bahjat, Geesje M. Dallinga
Publikováno v:
Atherosclerosis, 281, 189-197. Elsevier Ireland Ltd
Notwithstanding the intense efforts into the understanding and prevention of cardiovascular disease (CVD), its complex pathology remains the leading cause of mortality worldwide. The pivotal role of epigenetic changes in the control of gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e43e240993c5d5567fa927c2884141
https://doi.org/10.1016/j.atherosclerosis.2018.10.006
https://doi.org/10.1016/j.atherosclerosis.2018.10.006
Autor:
Jeffrey Kroon, Ewelina Kulikowski, Sylwia Wasiak, Norman C.W. Wong, Michael O. Sweeney, Yannick Kaiser, Brooke Rakai, Stephanie C. Stotz, Kim E. Dzobo, Erik S.G. Stroes, Miranda Versloot, Li Fu, Jan Johansson, Mahnoush Bahjat
Publikováno v:
Circulation. 142
Introduction: Hyperactivation of the monocyte inflammatory response is partly controlled by epigenetic mechanisms and contributes to atherosclerotic plaque formation in patients with cardiovascular disease (CVD) and type 2 diabetes mellitus (DM2). Hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f748d2c16c5db089949a408eb9c3b997
https://doi.org/10.1161/circ.142.suppl_3.14127
https://doi.org/10.1161/circ.142.suppl_3.14127
Autor:
Jeffrey Kroon, Miranda Versloot, Michael O. Sweeney, Kim E. Dzobo, Jan O. Johansson, Erik S.G. Stroes, Ewelina Kulikowski, Yannick Kaiser, Brooke Rakai, Li Fu, Mahnoush Bahjat, Sylwia Wasiak, Norman C.W. Wong, Stephanie C. Stotz
Publikováno v:
Clinical Epigenetics
Clinical epigenetics, 12(1):166. Springer Verlag
Clinical epigenetics, 12(1):166. Springer Verlag
Background Patients with cardiovascular disease (CVD) and type 2 diabetes (DM2) have a high residual risk for experiencing a major adverse cardiac event. Dysregulation of epigenetic mechanisms of gene transcription in innate immune cells contributes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82def708cf26b958cc587fba2bd35f5
http://europepmc.org/articles/PMC7657365
http://europepmc.org/articles/PMC7657365
Autor:
Stratigopoulou M, Richard J. Bende, Heinz Jacobs, Jeroen E. J. Guikema, Pilzecker B, van Dam Tp, van Noesel Cj, Mahnoush Bahjat, Mobach S
Publikováno v:
bioRxiv
In B cells, the error-prone repair of activation-induced cytidine deaminase (AID)-induced lesions in immunoglobulin variable genes cause somatic hypermutation (SHM) of antibody genes. Due to clonal selection in the germinal centers (GC) this active m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48755abf629204c12770db9f5f2fbcf4
https://doi.org/10.1101/2020.01.30.926964
https://doi.org/10.1101/2020.01.30.926964
Autor:
Wasiak, Sylwia, Dzobo, Kim E., Rakai, Brooke D., Kaiser, Yannick, Versloot, Miranda, Mahnoush Bahjat, Stotz, Stephanie C., Fu, Li, Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Stroes, Erik S. G., Kroon, Jeffrey, Kulikowski, Ewelina
Additional file 4–7. Additional file 4. Apabetalone’s gene targets in IPA® canonical pathways gene sets: Unstimulated control and DM2+CVD monocytes treated with apabetalone ex vivo. Additional file 5. Apabetalone’s gene targets that converge o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8e4ccce2aaef86357e2337874c1314
Autor:
Wasiak, Sylwia, Dzobo, Kim E., Rakai, Brooke D., Kaiser, Yannick, Versloot, Miranda, Mahnoush Bahjat, Stotz, Stephanie C., Fu, Li, Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Stroes, Erik S. G., Kroon, Jeffrey, Kulikowski, Ewelina
Additional file 1–3. Additional file 1. Analysis of monocyte subpopulations in control (CTL) and DM2+CVD patients. Monocytes were classified as classical (CD14++CD16−), intermediate (CD14++CD16+) or non-classical (CD14+CD16+). Fluorescence was me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e912928c6dca6d255b1b5725a6b28
Autor:
Jeroen E. J. Guikema, Timon A. Bloedjes, Carel J. M. van Noesel, Carol E. Schrader, Katarina Ochodnicka-Mackovicova, Richard J. Bende, Amélie van der Veen, Alexander M. de Bruin, Rudi W. Hendriks, Mahnoush Bahjat, Harmen van Andel, Chiel Maas, Els Verhoeyen
Publikováno v:
Journal of Immunology (Baltimore, Md.: 1950)
Journal of Immunology (Baltimore, Md.: 1950), 2016, 197 (7), pp.2918-2929. ⟨10.4049/jimmunol.1501989⟩
Journal of Immunology, 197(7), 2918-2929. American Association of Immunologists
Journal of immunology (Baltimore, Md., 197(7), 2918-2929. American Association of Immunologists
Journal of Immunology (Baltimore, Md.: 1950), 2016, 197 (7), pp.2918-2929. ⟨10.4049/jimmunol.1501989⟩
Journal of Immunology, 197(7), 2918-2929. American Association of Immunologists
Journal of immunology (Baltimore, Md., 197(7), 2918-2929. American Association of Immunologists
The recombination activating gene (RAG) 1 and RAG2 protein complex introduces DNA breaks at Tcr and Ig gene segments that are required for V(D)J recombination in developing lymphocytes. Proper regulation of RAG1/2 expression safeguards the ordered as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8a0ba48b384592759e30a151850d88
https://doi.org/10.4049/jimmunol.1501989
https://doi.org/10.4049/jimmunol.1501989
Autor:
Ewelina Kulikowski, Miranda Versloot, Mahnoush Bahjat, Christopher D. Sarsons, Li Fu, Laura Tsujikawa, Jeffrey Kroon, Dean Gilham, Erik S.G. Stroes, Stephanie C. Stotz, Brooke Rakai, Sylwia Wasiak, Norman C.W. Wong, Yannick Kaiser, Michael O. Sweeney, Kim E. Dzobo, Jan O. Johansson
Publikováno v:
Journal of the American College of Cardiology. 75:2217
Monocytes and macrophages are key immune cells in the development of cardiovascular disease (CVD). Dysregulated monocyte activation can be reversed by epigenetic therapies. Here we test the effects of apabetalone - a clinical-stage inhibitor of epige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96cb4ebbe30980ad41bb670b3f3f3b6e
https://doi.org/10.1016/s0735-1097(20)32844-8
https://doi.org/10.1016/s0735-1097(20)32844-8