Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mahnaz Minai"'
Autor:
Zarna Rajeshkumar Pala, Thiago Luiz Alves e Silva, Mahnaz Minai, Benjamin Crews, Eduardo Patino-Martinez, Carmelo Carmona-Rivera, Paola Carolina Valenzuela Leon, Ines Martin-Martin, Yevel Flores-Garcia, Raul E. Cachau, Liya Muslinkina, Apostolos G. Gittis, Naman Srivastava, David N. Garboczi, Derron A. Alves, Mariana J. Kaplan, Elizabeth Fischer, Eric Calvo, Joel Vega-Rodriguez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The evolution of hematophagy involves a series of adaptations that allow blood-feeding insects to access and consume blood efficiently while managing and circumventing the host’s hemostatic and immune responses. Mosquito, and other insects
Externí odkaz:
https://doaj.org/article/5f36b17f5200404f8da58a835144cc00
Autor:
Ines Martin-Martin, Bianca Burini Kojin, Azadeh Aryan, Adeline E. Williams, Alvaro Molina-Cruz, Paola Carolina Valenzuela-Leon, Gaurav Shrivastava, Karina Botello, Mahnaz Minai, Zach N. Adelman, Eric Calvo
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTMosquito saliva facilitates blood meal acquisition through pharmacologically active compounds that prevent host hemostasis and immune responses. Here, we generated two knockout (KO) mosquito lines by CRISPR/Cas9 to functionally characterize D
Externí odkaz:
https://doaj.org/article/3cccb39e9ce743b2811975d69e58eeef
Autor:
Olga A Maximova, Melodie L Weller, Tammy Krogmann, Daniel E Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Craig Martens, Kurt Wollenberg, Mahnaz Minai, Ian N Moore, Craig S Sauter, Juliet N Barker, W Ian Lipkin, Danielle Seilhean, Avindra Nath, Jeffrey I Cohen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011544 (2023)
Astroviruses (AstVs) can cause of severe infection of the central nervous system (CNS) in immunocompromised individuals. Here, we identified a human AstV of the VA1 genotype, HAstV-NIH, as the cause of fatal encephalitis in an immunocompromised adult
Externí odkaz:
https://doaj.org/article/bb23eb1b94ac407f968c090e9fa6efa1
Autor:
Dapeng Li, David R. Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L. Sutherland, Esther Lee, Robert Parks, Dieter Mielke, Whitney Edwards, Amanda Newman, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Matthew Gagne, Daniel C. Douek, C. Todd DeMarco, Thomas N. Denny, Thomas H. Oguin, Alecia Brown, Wes Rountree, Yunfei Wang, Katayoun Mansouri, Robert J. Edwards, Guido Ferrari, Gregory D. Sempowski, Amanda Eaton, Juanjie Tang, Derek W. Cain, Sampa Santra, Norbert Pardi, Drew Weissman, Mark A. Tomai, Christopher B. Fox, Ian N. Moore, Hanne Andersen, Mark G. Lewis, Hana Golding, Robert Seder, Surender Khurana, Ralph S. Baric, David C. Montefiori, Kevin O. Saunders, Barton F. Haynes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidat
Externí odkaz:
https://doaj.org/article/b08586c46f7c4fa6b00bfd070a9caed1
Autor:
Simon D. van Haren, Gabriel K. Pedersen, Azad Kumar, Tracy J. Ruckwardt, Syed Moin, Ian N. Moore, Mahnaz Minai, Mark Liu, Jensen Pak, Francesco Borriello, Simon Doss-Gollin, Elisabeth M. S. Beijnen, Saima Ahmed, Michaela Helmel, Peter Andersen, Barney S. Graham, Hanno Steen, Dennis Christensen, Ofer Levy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Respiratory syncytial virus is a major pathogen with burden observed and associated with childhood infection. Here the authors characterise a cationic adjuvant formulation and show single immunisation results in protection in a murine neonate model o
Externí odkaz:
https://doaj.org/article/928f6a30307d40df8ee70a438b361824
Autor:
Yongjun Sui, Jianping Li, Roushu Zhang, Sunaina Kiran Prabhu, Hanne Andersen, David Venzon, Anthony Cook, Renita Brown, Elyse Teow, Jason Velasco, Jack Greenhouse, Tammy Putman-Taylor, Tracey-Ann Campbell, Laurent Pessaint, Ian N. Moore, Laurel Lagenaur, Jim Talton, Matthew W. Breed, Josh Kramer, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Mark G. Lewis, Lai-Xi Wang, Jay A. Berzofsky
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies have focused on systemic immunization, here we compared the protective efficacy of 2 adjuvanted subunit vaccines with spike protein S1: an intramuscularly primed/boos
Externí odkaz:
https://doaj.org/article/d56cb415c28b4c54afc3a16c9c73cf2f
Autor:
Olga A Maximova, Daniel E Sturdevant, John C Kash, Kishore Kanakabandi, Yongli Xiao, Mahnaz Minai, Ian N Moore, Jeff Taubenberger, Craig Martens, Jeffrey I Cohen, Alexander G Pletnev
Publikováno v:
eLife, Vol 10 (2021)
Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of
Externí odkaz:
https://doaj.org/article/f1bcbe0ee4784370bebae50309d87d77
Autor:
Caroline M. Percopo, Michelle Ma, Eric Mai, Jamie L. Redes, Laura S. Kraemer, Mahnaz Minai, Ian N. Moore, Kirk M. Druey, Helene F. Rosenberg
Publikováno v:
Viruses, Vol 12, Iss 9, p 946 (2020)
Chronic inhalation of fungi and fungal components has been linked to the development of respiratory disorders, although their role with respect to the pathogenesis of acute respiratory virus infection remains unclear. Here, we evaluate inflammatory p
Externí odkaz:
https://doaj.org/article/e4d406b97e9047b2bd761a7ae94811f7
Autor:
Katherine V Houser, Andrew J Broadbent, Lisa Gretebeck, Leatrice Vogel, Elaine W Lamirande, Troy Sutton, Kevin W Bock, Mahnaz Minai, Marlene Orandle, Ian N Moore, Kanta Subbarao
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006565 (2017)
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic betacoronavirus that was first detected in humans in 2012 as a cause of severe acute respiratory disease. As of July 28, 2017, there have been 2,040 confirmed cases with 712 re
Externí odkaz:
https://doaj.org/article/5499366309094999abbabe0c5e7acc35
Autor:
Joseph P. Cornish, Ian N. Moore, Donna L. Perry, Abigail Lara, Mahnaz Minai, Dominique Promeneur, Katie R. Hagen, Kimmo Virtaneva, Monica Paneru, Connor R. Buechler, David H. O’Connor, Adam L. Bailey, Kurt Cooper, Steven Mazur, John G. Bernbaum, James Pettitt, Peter B. Jahrling, Jens H. Kuhn, Reed F. Johnson
Publikováno v:
Viruses, Vol 11, Iss 1, p 67 (2019)
Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas). This diff
Externí odkaz:
https://doaj.org/article/033038cb3e204f3ca7676a9959afd180