Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Mahnaz, Asgharnejad"'
Autor:
Wei Yin, Pranab Mitra, Veronique Copalu, Thomas C. Marbury, Juan Carlos Rondon, Eric J. Lawitz, Valerie Lloyd, Mike Baratta, Mahnaz Asgharnejad, Tom Hui, Yasir Khan
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract This phase 1, open‐label, three‐arm study (NCT05098054) compared the pharmacokinetics and safety of soticlestat (TAK‐935) in participants with hepatic impairment. Participants aged ≥18 to
Externí odkaz:
https://doaj.org/article/f54bfb954336446f92cc2bd5c1afa903
Autor:
Wei Yin, Axel Facius, Thomas Wagner, Max Tsai, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1149-1162 (2023)
Abstract Soticlestat is a first‐in‐class, selective inhibitor of cholesterol 24‐hydroxylase (CH24H), which catabolizes cholesterol to 24S‐hydroxycholesterol (24HC) in the brain, in phase III development for Dravet syndrome and Lennox–Gastau
Externí odkaz:
https://doaj.org/article/d8161f844dbe4084876acfaf7017a01e
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Soticlestat (TAK‐935) is a first‐in‐class, selective inhibitor of cholesterol 24‐hydroxylase (CH24H) under phase III development for the treatment of the developmental and epileptic encephalopathies (DEEs), Dravet syndrome (DS), and
Externí odkaz:
https://doaj.org/article/c7dd036bd4d44372b241f37bb1053a8c
Autor:
Francis Dijkstra, Patricio O’Donnell, Erica Klaassen, Derek Buhl, Mahnaz Asgharnejad, Laura Rosen, Rob Zuiker, Joop van Gerven, Gabriël Jacobs
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract TAK-653 is a novel AMPA receptor positive allosteric modulator in clinical development for the treatment of major depressive disorder (MDD). This study aimed to measure the functional pharmacodynamic central nervous system (CNS) effects of T
Externí odkaz:
https://doaj.org/article/62a8cd476bd44bbca0c331fce96852f3
Autor:
Patricio O’Donnell, Francis M. Dijkstra, Ugur Damar, Lei Quanhong, Annika A. de Goede, Lin Xu, Andres Pascual-Leone, Derek L. Buhl, Rob Zuiker, Titia Q. Ruijs, Jules A. A. C. Heuberger, Paul MacMullin, Martin Lubell, Mahnaz Asgharnejad, Venkatesha Murthy, Alexander Rotenberg, Gabriel E. Jacobs, Laura Rosen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract TAK-653 is a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-positive allosteric modulator being developed as a potential therapeutic for major depressive disorder (MDD). Currently, there are no translational bio
Externí odkaz:
https://doaj.org/article/ce48b7411ac043d4865d94fd37a9f0e7
Autor:
Patricio O’Donnell, Cheng Dong, Venkatesha Murthy, Mahnaz Asgharnejad, Xiaoming Du, Ann Summerfelt, Hong Lu, Lin Xu, Jens R. Wendland, Eduardo Dunayevich, Derek L. Buhl, Robert Litman, William P. Hetrick, L. Elliot Hong, Laura B. Rosen
Publikováno v:
Neuropsychopharmacology. 48:1052-1059
Several attempts have been made to enhance N-methyl-D-aspartate (NMDA) receptor function in schizophrenia, but they have yielded mixed results. Luvadaxistat, a D-amino acid oxidase (DAAO) inhibitor that increases the glutamate co-agonist D-serine lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c93f6ae00e1e9862d1fe73d00622eaf
https://doi.org/10.1038/s41386-023-01560-0
https://doi.org/10.1038/s41386-023-01560-0
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225723 (2019)
ObjectivesThe objective of the study was to describe treatment patterns in patients newly diagnosed with Parkinson's disease (PD) in the United States (US) and the United Kingdom (UK).MethodsThis retrospective cohort study used the US IBM MarketScan
Externí odkaz:
https://doaj.org/article/657a565cdd4e48ff8021ed7d6c513894
Autor:
Venkatesha Murthy, Dennis Dlugos, Yasir Khan, Samuel Hsiao, Arturo Benitez, Mahnaz Asgharnejad
Publikováno v:
Wednesday, April 26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d94989ae8fa98e3a56c222a7c9be5b43
https://doi.org/10.1212/wnl.0000000000203534
https://doi.org/10.1212/wnl.0000000000203534
Publikováno v:
Thursday, April 27.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0efc0308aa258503781097f7ae2018b6
https://doi.org/10.1212/wnl.0000000000202980
https://doi.org/10.1212/wnl.0000000000202980
Autor:
Cecil D. Hahn, Yuwu Jiang, Vicente Villanueva, Marta Zolnowska, Dimitrios Arkilo, Samuel Hsiao, Mahnaz Asgharnejad, Dennis Dlugos
Publikováno v:
EpilepsiaREFERENCES. 63(10)
Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) are rare treatment-resistant childhood epilepsies classed as developmental and epileptic encephalopathies. ELEKTRA investigated the efficacy and safety of soticlestat (TAK-935) as adjunctive ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1721b46ea100d56a3375c0adf84f08d
https://pubmed.ncbi.nlm.nih.gov/35841234
https://pubmed.ncbi.nlm.nih.gov/35841234