l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.

Autor: Kundu A; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Department of Urology, University of Arizona, Tuscon, Arizona, USA., Brinkley GJ; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Nam H; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Karki S; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Kirkman R; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Pandit M; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Shim E; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Widden H; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA., Liu J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Heidarian Y; Department of Biology, Indiana University, Bloomington, Indiana, USA., Mahmoudzadeh NH; Department of Biology, Indiana University, Bloomington, Indiana, USA., Fitt AJ; Department of Biology, Indiana University, Bloomington, Indiana, USA., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA., Ding HF; Department of Pathology and., Crossman DK; Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA., Placzek WJ; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA., Locasale JW; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Rakheja D; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., McConathy JE; Department of Radiology and., Ramachandran R; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Bae S; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Tennessen JM; Department of Biology, Indiana University, Bloomington, Indiana, USA., Sudarshan S; Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 14; Vol. 134 (13). Date of Electronic Publication: 2024 May 14.

Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase.

Autor: Heidarian Y; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Tourigny JP; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Fasteen TD; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Mahmoudzadeh NH; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Hurlburt AJ; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Nemkov T; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Reisz JA; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., D'Alessandro A; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Tennessen JM; Department of Biology, Indiana University, Bloomington, IN 47405, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 19. Date of Electronic Publication: 2023 Jun 19.

Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation.

Autor: Taub M; Biochemistry Department, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States., Mahmoudzadeh NH; Department of Biology, Indiana University, Bloomington, IN, United States., Tennessen JM; Department of Biology, Indiana University, Bloomington, IN, United States., Sudarshan S; Department of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Sep 05; Vol. 13, pp. 932286. Date of Electronic Publication: 2022 Sep 05 (Print Publication: 2022).

The oncometabolite L-2-hydroxyglutarate is a common product of dipteran larval development.

Autor: Mahmoudzadeh NH; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Fitt AJ; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Schwab DB; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Martenis WE; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Nease LM; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Owings CG; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA., Brinkley GJ; Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA., Li H; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Karty JA; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Sudarshan S; Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA., Hardy RW; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Moczek AP; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Picard CJ; Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA., Tennessen JM; Department of Biology, Indiana University, Bloomington, IN 47405, USA. Electronic address: jtenness@indiana.edu.

Publikováno v: Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2020 Dec; Vol. 127, pp. 103493. Date of Electronic Publication: 2020 Nov 03.