Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Mahmoud N. Nagi"'
Autor:
Abdulrazaq Alanazi, Mahmoud N. Nagi, Dhafer Y. Alhareth, Mohammed A Al-Hamamah, Mohamed A Mahmoud, Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Gamaleldin I. Harisa, Sabry M. Attia
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 3, Pp 370-381 (2023)
Purpose: The clinical study of fulminant hepatic failure is challenging due to its high mortality and relative rarity, necessitating reliance on pre-clinical models to gain insight into its pathophysiology and develop potential therapies. Methods and
Externí odkaz:
https://doaj.org/article/d30518938ed445c7a3823b609e4cd5d4
Autor:
Dhafer Y. Alhareth, Abdulrazaq Alanazi, Wael A. Alanazi, Mushtaq A. Ansari, Mahmoud N. Nagi, Sheikh F. Ahmad, Mohamed S. M. Attia, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3098 (2023)
Acute liver failure (ALF) is a disease accompanied by severe liver inflammation. No effective therapy is available yet apart from liver transplantation; therefore, developing novel treatments for ALF is urgently required. Inflammatory mediators relea
Externí odkaz:
https://doaj.org/article/377e22039d62499abf9dd7b217fdf5e7
Autor:
Hussein I. El-Subbagh, El-Sayed E. Habib, Mahmoud N. Nagi, Shahenda M. El-Messery, Ghada S. Hassan, Sarah T. Al-Rashood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4815-4823
A new series of 2,3,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 28 and 61 proved to be active DHFR inhibitors with IC50 0.02 and 0.01
Publikováno v:
Drug development research. 80(4)
An overdose of acetaminophen (APAP) causes liver injury in experimental animals and humans. The activation step (formation of reactive metabolite, N-acetyl-p-benzoquinone imine by cytochrome P450 system) and the consequent downstream pathway of oxida
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 30:5-11
Prophylactic and therapeutic effects of acetylcarnitine against acetaminophen-induced hepatotoxicity were studied in mice. To evaluate the prophylactic effects of acetylcarnitine, mice were supplemented with acetylcarnitine (2 mmol/kg/day per oral (p
Autor:
Mohamed M. Hafez, Mahmoud N. Nagi, Mohammed M. Sayed-Ahmed, Mohammed M. Al-Harbi, Othman A. Al-Shabanah, Hesham M. Korashy, Ahmed Nadeem, Naif O. Al-Harbi, Saleh A. Bahashwan, Faisal Imam
Publikováno v:
Toxicology Mechanisms and Methods. 25:417-423
Riboflavin (vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) and is therefore r
Autor:
Hussein I. El-Subbagh, Ghada S. Hassan, Sarah T. Al-Rashood, Fatmah A.M. Al-Omary, Shahenda M. El-Messery, El-Sayed E. Habib, Mahmoud N. Nagi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4557-4567
A new series of 2-(1,3,4-thiadiazolyl- or 4-methyl-thiazolyl)thio-6-substituted-quinazolin-4-one analogs was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 29, 34, and 39 pr
Autor:
Ammar C. Al-Rikabi, Khaled A. Al-Hosaini, Mahmoud N. Nagi, Mahmoud A. Mansour, Mohammed A. Aljoufi
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 28:400-406
The antineoplastic effect of carfilzomib (CFZ) against chemically induced hepatocarcinogenesis was studied. A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group. Rats in group 1 (control group) were given d
Autor:
Ammar C. Al-Rikabi, Mahmoud N. Nagi, Mahmoud A. Mansour, Khaled A. Al-Hosaini, Mohammed A. Aljoufi
Publikováno v:
Chemico-Biological Interactions. 215:17-24
We investigated the possible therapeutic effect of irreversible proteasome inhibitor, carfilzomib against hepatocellular carcinoma induced chemically by chronic administration of diethylnitrosoamines (DENA). Hepatocellular carcinoma induced by DENA i
Autor:
Hesham M. Korashy, Mahmoud N. Nagi, Faisal Imam, Saleh G. Algfeley, Abdulrazaq Alanazi, Khaled A. Al-Hosaini
Publikováno v:
Journal of biochemical and molecular toxicology. 31(4)
Overdose of acetaminophen (APAP) is often associated with hepatotoxicity. Carfilzomib (CFZ) shows multiple pharmacological activities including anti-inflammatory potential. Therefore, this study was undertaken to evaluate the possible therapeutic eff