Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mahmoud Mohamed Mokhtar"'
Autor:
Omnia R. Elbatrawy, Mohamed Hagras, Moshira A. El Deeb, Fatimah Agili, Maghawry Hegazy, Ahmed A. El-Husseiny, Mahmoud Mohamed Mokhtar, Samy Y. Elkhawaga, Ibrahim H. Eissa, Samar El-Kalyoubi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 966 (2023)
Background: Histone deacetylase inhibitors (HDACIs) are a relatively new class of potential drugs for treating cancer. Aim: Discovery of new anticancer agents targeting HDAC. Methods: New uracil and thiouracil derivatives panels were designed and syn
Externí odkaz:
https://doaj.org/article/aaf9f96a1e06487090579a384e6ac32f
Autor:
Mahmoud Mohamed Mokhtar, Hesham Mohamed Shaban, Mohamed El-amir F. Hegazy, Shawkey Seddik Ali
Publikováno v:
Bulletin of Faculty of Pharmacy Cairo University, Vol 55, Iss 1, Pp 195-201 (2017)
Cancer is the second leading cause of death world-wide. One of the most important medical practices of the 21st century is the chemoprevention of cancer. For a long history, it has been accepted that plants could prevent and exert suitable anti-carci
Externí odkaz:
https://doaj.org/article/0bcae1bb3f654e368c2521a90863b207
Autor:
Eman M Azmy, Ibrahim F Nassar, Mohamed Hagras, Iten M Fawzy, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Amr Mohamed Yehia, Nasser SM Ismail, Walaa H Lashin
Publikováno v:
Future Medicinal Chemistry. 15:473-495
Background: Alzheimer's disease is a neurological disorder that causes brain cells to shrink and die. Aim: Thirteen novel ‘oxathiolanyl’, ‘pyrazolyl’ and ‘pyrimidinyl’ indole derivatives were designed and synthesized as anti-Alzheimer's d
Autor:
Ibrahim F. Nassar, Mohammed T. Abdel Aal, Wael A. El-Sayed, Mahmoud A. E Shahin, Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Mohamed Hagras, Asmaa A. Mandour, Nasser S. M. Ismail
Publikováno v:
RSC Advances. 12:14865-14882
A new set of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffolds (4–13) as well as the thioglycoside derivatives (14, 15) were designed, and synthesized as novel CDK2 targeting compounds.
Autor:
Maghawry Hegazy, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G.E. Elsakka, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Ahmed Elshafei, Tamer M. Abdelghany, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy, Ahmed S. Doghish
Publikováno v:
Pathology - Research and Practice. 246:154510
Autor:
Ahmed S. Doghish, Maghawry Hegazy, Ahmed Ismail, Hesham A. El-Mahdy, Elsayed G.E. Elsakka, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia, Nourhan M. Abdelmaksoud, Mahmoud Mohamed Mokhtar
Publikováno v:
Pathology - Research and Practice. 245:154442
Autor:
Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed Ismail, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G.E. Elsakka
Publikováno v:
Pathology - Research and Practice. 243:154371
Autor:
Ibrahim F, Nassar, Mohammed T, Abdel Aal, Wael A, El-Sayed, Mahmoud, A E Shahin, Elsayed G E, Elsakka, Mahmoud Mohamed, Mokhtar, Maghawry, Hegazy, Mohamed, Hagras, Asmaa A, Mandour, Nasser S M, Ismail
Publikováno v:
RSC advances. 12(23)
CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a selective manner. A new set of small molecules featuring the privileged pyrazolo[3,4
Autor:
Elsayed G.E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Ahmed Ismail, Ahmed S. Doghish
Publikováno v:
Life Sciences. 308:120923
The endocytosis mechanism is a complicated system that is essential for cell signaling and survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are impor
Autor:
Hesham Mohamed Shaban, Emad Gamil Khidr, Bakheet E. M. Elsadek, Salama Abdou Salama, Shady Allam, Mahmoud Mohamed Mokhtar, Shawkey Saddik Ali
Publikováno v:
Environmental science and pollution research international. 27(14)
Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor xenobiotic response element (XRE) in their promoter regions. Thus, PAHs/AhR could alter the