Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Mahmoud M. Abdel-Monem"'
Publikováno v:
Journal of medicinal chemistry. 35(23)
The utility of the spermidine moiety as the homing device for the selective delivery of chemotherapeutic and diagnostic agents into cancer cells was explored. Two spermidine analogs containing a cytotoxic agent were synthesized, N-[3,4-bis(benzyloxy)
Publikováno v:
Journal of Medicinal Chemistry. 24:549-553
Seven analogues of S-adenosyl-L-methionine were studied as inhibitors or substrates for mammalian spermidine and spermine synthases. One of these, S-(5'-deoxy-5'-adenosyl)-(+/-)-1-methyl-3-(methylthio)propylamine (5), showed a unique spectrum of acti
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1586-1589
The effects of a-methyl-(±)-ornithine and its tert -butyl ester on the survival time and the levels of polyamines in spleen tissue of mice inoculated intraperitoneally with L-1210 lymphoid leukemic cells were studied in vivo . These compounds were a
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 24:1061-1070
Iodine-125 labeled analog of 12-O-tetradecanoylphorbol-13-acetate (TPA) was obtained by heating the iodine substituted analog of TPA in acetone with sodium [125I] iodide. The iodine substituted analog of TPA, 12-O-(12′-iodododecanoyl)phorbol-13-ace
Autor:
Mahmoud M. Abdel-Monem
Publikováno v:
Journal of Medicinal Chemistry. 18:427-430
The N-demethylation of 1-(N-methyl-N-trideuteriomethylamino)-3-phenylpropane (1) by rodent liver homogenates was studied. The ratio of 1-trideuteriomethylamino-3-phenylpropane (2)/1-methylamino-3-phenylpropane (3) was determined by gc-ms. The ratio o
Publikováno v:
Journal of Medicinal Chemistry. 23:121-127
Publikováno v:
Journal of Medicinal Chemistry. 26:66-71
Substrate enantioselectivity in the conjugation of phenethyl halides catalyzed by the glutathione S-transferases was studied with partially purified isozymes from rat liver. All of the isozymes tested possessed measurable activity with phenethyl chlo
Publikováno v:
Journal of Medicinal Chemistry. 17:447-451
Publikováno v:
Journal of Medicinal Chemistry. 20:249-253
L1210 leukemic cells of mice were incubated for a period of two generations in the presence of either alpha-methyl-(+/-)-ornithine, an inhibitor of ornithine decarboxylase, or methylglyoxal bis(guanylhydroazone), an inhibitor of S-adenosylmethionine
Publikováno v:
Journal of Medicinal Chemistry. 16:992-995