Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Mahmoud M El-Mas"'
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142303 (2015)
Nephrotoxicity is a major side effect for the antineoplastic drug cisplatin. Here, we employed pharmacological, biochemical, and molecular studies to investigate the role of peroxisome proliferator-activated receptors (PPARs) in cisplatin nephrotoxic
Externí odkaz:
https://doaj.org/article/910f7712db4c4f80a8082ea7965682b6
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95079 (2014)
We investigated the effect of chronic nicotine on cholinergically-mediated renal vasodilations in female rats and its modulation by the nitric oxide synthase (NOS)/heme oxygenase (HO) pathways. Dose-vasodilatory response curves of acetylcholine (0.01
Externí odkaz:
https://doaj.org/article/2458538344614829b809b9dee5fa2f8a
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98681 (2014)
We recently reported that chronic nicotine impairs reflex chronotropic activity in female rats. Here, we sought evidence to implicate nitric oxide synthase (NOS) and/or heme oxygenase (HO) in the nicotine-baroreflex interaction. Baroreflex curves rel
Externí odkaz:
https://doaj.org/article/530db7b80b75423ca943cb7d1d625ff4
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Despite the established role of peripheral adenosine receptors in sepsis-induced organ dysfunction, little or no data is available on the interaction of central adenosine receptors with sepsis. The current study tested the hypothesis th
Externí odkaz:
https://doaj.org/article/b87cbeab7cfd4a778f2ffba87247a8a9
Autor:
Evans O. Ayieng’a, Elham A. Afify, Salwa A. Abuiessa, Samar S. Elblehi, Sahar M. El-Gowilly, Mahmoud M. El-Mas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Although pain and sepsis are comorbidities of intensive care units, reported data on whether pain control by opioid analgesics could alter inflammatory and end-organ damage caused by sepsis remain inconclusive. Here, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/bcb5fa306eaf4d9db41adc7003ab51d4
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The cholinergic pathway plays a crucial role in improving inflammatory end-organ damage. Given the interplay between cholinergic and adenosinergic neurotransmission, we tested the hypothesis that central adenosine A1 receptors (A1ARs) modula
Externí odkaz:
https://doaj.org/article/7cefe149e1fd49478e74cde842e89efd
Autor:
Sherien A. Abdelhady, Mennatallah A. Ali, Dalia M. Yacout, Marwa M. Essawy, Lamia S. Kandil, Mahmoud M. El-Mas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Although nonsteroidal antiinflammatory drugs (NSAIDs) are frequently used for fever and pain during pregnancy, their possible interaction with perinatal renal injury induced by preeclampsia (PE) has not been addressed. Here, studies were und
Externí odkaz:
https://doaj.org/article/ac365318ca284078b0ba029d07989e5f
Autor:
Hagar A. Morgaan, Marwa Y. Sallam, Hanan M. El-Gowelli, Sahar M. El-Gowilly, Mahmoud M. El-Mas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract We recently reported exacerbated endotoxic signs of neuroinflammation and autonomic defects in offspring of preeclamptic (PE) dams. Here, we investigated whether PE programming similarly modifies hemodynamic and renal vasoconstrictor respons
Externí odkaz:
https://doaj.org/article/47c40974c3d34fdcb8c479a9bb4e1adf
Autor:
Hagar A. Morgaan, Marwa Y. Sallam, Hanan M. El-Gowelli, Sahar M. El-Gowilly, Mahmoud M. El-Mas
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Preeclampsia (PE) enhances the vulnerability of adult offspring to serious illnesses. The current study investigated whether preeclamptic fetal programming impacts hemodynamic and renal vasodilatory disturbances in endotoxic adult offsp
Externí odkaz:
https://doaj.org/article/577733778c734e84bad82019c637d6b0
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Metabolic syndrome (MetS) is closely associated with the development of cardiovascular diseases. We recently developed a nano-preparation of the flavonoid quercetin (QU) in a self-nanoemulsifying drug delivery system (SNEDDS). The latter comprised a
Externí odkaz:
https://doaj.org/article/bdd1caddafde4bb0979bbd0caff28296