A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

Autor: Alison J. Hardcastle, Petra Liskova, Yelena Bykhovskaya, Bennet J. McComish, Alice E. Davidson, Chris F. Inglehearn, Xiaohui Li, Hélène Choquet, Mahmoud Habeeb, Sionne E. M. Lucas, Srujana Sahebjada, Nikolas Pontikos, Karla E. Rojas Lopez, Anthony P. Khawaja, Manir Ali, Lubica Dudakova, Pavlina Skalicka, Bart T. H. Van Dooren, Annette J. M. Geerards, Christoph W. Haudum, Valeria Lo Faro, Abi Tenen, Mark J. Simcoe, Karina Patasova, Darioush Yarrand, Jie Yin, Salina Siddiqui, Aine Rice, Layal Abi Farraj, Yii-Der Ida Chen, Jugnoo S. Rahi, Ronald M. Krauss, Elisabeth Theusch, Jac C. Charlesworth, Loretta Szczotka-Flynn, Carmel Toomes, Magda A. Meester-Smoor, Andrea J. Richardson, Paul A. Mitchell, Kent D. Taylor, Ronald B. Melles, Anthony J. Aldave, Richard A. Mills, Ke Cao, Elsie Chan, Mark D. Daniell, Jie Jin Wang, Jerome I. Rotter, Alex W. Hewitt, Stuart MacGregor, Caroline C. W. Klaver, Wishal D. Ramdas, Jamie E. Craig, Sudha K. Iyengar, David O’Brart, Eric Jorgenson, Paul N. Baird, Yaron S. Rabinowitz, Kathryn P. Burdon, Chris J. Hammond, Stephen J. Tuft, Pirro G. Hysi

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Alison Hardcastle et al. report a genome-wide meta-analysis of keratoconus, a condition affecting the cornea that causes blurred vision and often leads to blindness. They identify 36 genomic regions associated with keratoconus, 31 of which are novel,

Externí odkaz: https://doaj.org/article/6eed77457b784436985e138a87c60544

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

Autor: Szymon M. Kielbasa, Onno C. Meijer, Mahmoud Habeeb, Elon H.C. van Dijk, Roula Tsonaka, H.A.B. Peters, Aikaterini Nikolaou, Silvère M. van der Maarel, Camiel J. F. Boon, Arjanneke F van de Merbel, Hetty C M Sips, Robbert G E Notenboom, Eiko K. de Jong, Paul H.A. Quax, Joost Brinks

Publikováno v: Investigative Ophthalmology and Visual Science, 59, 13, pp. 5682-5692
Investigative Ophthalmology & Visual Science
Investigative ophthalmology & visual science, 59(13), 5682-5692. Association for Research in Vision and Ophthalmology Inc.
Investigative Ophthalmology and Visual Science, 59, 5682-5692
Investigative Ophthalmology & Visual Science, 59(13), 5682-5692

Purpose To isolate, culture, and characterize primary human choroidal endothelial cells, and to assess their responsiveness to corticosteroids, in order to enable knowledge gain on the pathogenesis of central serous chorioretinopathy. Methods Choroid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5caa1e4b02d2de9de6caab04ffa350a
https://hdl.handle.net/2066/199530