Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mahmoud H. Abou Alaiwa"'
Autor:
Jamison J. Ash, Brieanna M. Hilkin, Nicholas D. Gansemer, Eric A. Hoffman, Joseph Zabner, David A. Stoltz, Mahmoud H. Abou Alaiwa
Publikováno v:
Physiological Reports, Vol 10, Iss 17, Pp n/a-n/a (2022)
Abstract In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl− and HCO3− secretion across the epithelium acidifies the airway surface liquid (ASL). Acidic ASL alters two key host defense mech
Externí odkaz:
https://doaj.org/article/e7ce31a60a064de3a40bb97a10f5ad50
Autor:
Carley G. Stewart, Brieanna Hilkin, Nicholas D. Gansemer, Susan A. Walsh, Michael R. Acevado, Vamsidhar Akurathi, Darpan N. Pandya, Alejandro F. Comellas, Thaddeus J. Wadas, David W. Dick, John J. Sunderland, David A. Stoltz, Michael J. Welsh, Mahmoud H. Abou Alaiwa
Publikováno v:
2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d1a5746484290a393557c893baf6e7c
https://doi.org/10.1109/isbi52829.2022.9761605
https://doi.org/10.1109/isbi52829.2022.9761605
Autor:
Maria I. Pino-Argumedo, Anthony J. Fischer, Brieanna M. Hilkin, Nicholas D. Gansemer, Patrick D. Allen, Eric A. Hoffman, David A. Stoltz, Michael J. Welsh, Mahmoud H. Abou Alaiwa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
SignificanceIn many lung diseases, increased amounts of and/or abnormal mucus impair mucociliary clearance, a key defense against inhaled and aspirated material. Submucosal glands lining cartilaginous airways secrete mucus strands that are pulled by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07844f3766b1f2cd54a0fbe0d1201ba
https://pubmed.ncbi.nlm.nih.gov/35324331
https://pubmed.ncbi.nlm.nih.gov/35324331
Autor:
Ultan F. Power, Mahmoud H. Abou Alaiwa, Paul B. McCray, Steven M. Varga, Abigail R. Berkebile, Jennifer A. Bartlett
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Berkebile, A R, Bartlett, J A, Alaiwa, M A, Varga, S M, Power, U & McCray, P B 2020, ' Airway surface liquid has innate antiviral activity that is reduced in cystic fibrosis ', American Journal of Respiratory Cell and Molecular Biology, vol. 62, no. 1, pp. 104-111 . https://doi.org/10.1165/rcmb.2018-0304OC
Am J Respir Cell Mol Biol
Berkebile, A R, Bartlett, J A, Alaiwa, M A, Varga, S M, Power, U & McCray, P B 2020, ' Airway surface liquid has innate antiviral activity that is reduced in cystic fibrosis ', American Journal of Respiratory Cell and Molecular Biology, vol. 62, no. 1, pp. 104-111 . https://doi.org/10.1165/rcmb.2018-0304OC
Although chronic bacterial infections and inflammation are associated with progressive lung disease in patients with cystic fibrosis (CF), much less is known regarding the contributions of respiratory viral infections to this process. Clinical studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87f555e68bffc214ea8c40f9d9286cb
https://doi.org/10.1165/rcmb.2018-0304oc
https://doi.org/10.1165/rcmb.2018-0304oc
Autor:
Xiaopeng Li, Mahmoud H. Abou Alaiwa, Alejandro A. Pezzulo, Joseph Zabner, Bradley A. Hamilton
Publikováno v:
Gene Therapy. 26:240-249
Adeno-associated virus (AAV) has been investigated to transfer the cystic fibrosis transmembrane conductance regulator (CFTR) to airways. Inhaled AAV2-CFTR in people with cystic fibrosis (CF) is safe, but inefficient. In vitro, AAV2 transduction of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ed2285b619c8ac7b972980d17b18c2
https://doi.org/10.1038/s41434-019-0078-3
https://doi.org/10.1038/s41434-019-0078-3
Autor:
Oliver G Chen, Christian M Brommel, Xiaopeng Li, Joseph Zabner, Annie Ehler, David A. Stoltz, Raul Villacreses, Reda E. Girgis, Steven E Mather, Bradley A. Hamilton, Mahmoud H. Abou Alaiwa
Publikováno v:
Cells, Vol 10, Iss 1014, p 1014 (2021)
Cells
Volume 10
Issue 5
Cells
Volume 10
Issue 5
Cystic fibrosis (CF) is caused by genetic mutations of the CF transmembrane conductance regulator (CFTR), leading to disrupted transport of Cl− and bicarbonate and CF lung disease featuring bacterial colonization and chronic infection in conducting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c4fee558752f68cda471f28b253665
https://www.mdpi.com/2073-4409/10/5/1014
https://www.mdpi.com/2073-4409/10/5/1014
Autor:
Alejandro A. Pezzulo, Ryan J. Adam, Daniel P. Cook, Patrick Ten Eyck, Mahmoud H. Abou Alaiwa, David K. Meyerholz, Drake C. Bouzek, Chaorong Wu, David A. Stoltz, Maria I Aguilar Pescozo, Eric A. Hoffman, Douglas B. Hornick, Leah R. Reznikov, Thomas J. Gross
Publikováno v:
Am J Respir Crit Care Med
Rationale: Although it is clear that cystic fibrosis (CF) airway disease begins at a very young age, the early and subsequent steps in disease pathogenesis and the relative contribution of infection, mucus, and inflammation are not well understood. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402a19c32556cfb054eea5ca70dc59c7
https://europepmc.org/articles/PMC8521711/
https://europepmc.org/articles/PMC8521711/
Autor:
Eric A. Hoffman, Randall S. Prather, Thomas R. Businga, Margaret P. Price, Lynda S. Ostedgaard, Guillermo S Romano Ibarra, Brian J Goodell, Patrick D Allen, Mallory R. Stroik, Melissa Samuel, Miguel E Ortiz Bezara, David K. Meyerholz, Camilla E Hippee, Steven E Mather, Linda S. Powers, Michael J. Welsh, Lee D. Spate, Nicholas D. Gansemer, Mahmoud H. Abou Alaiwa, Brieanna M Hilkin, Akshaya Warrier, Kristin M. Whitworth, David A. Stoltz, J. Adam Goeken, Anthony J. Fischer, Keyan Zarei
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834a3d41d31d73ae10c97cca093f72dc
http://europepmc.org/articles/PMC7541087
http://europepmc.org/articles/PMC7541087
Autor:
Akshaya Warrier, Lynda S. Ostedgaard, Michael J. Welsh, Randall S. Prather, Thomas R. Businga, Margaret P. Price, Brieanna M Hilkin, Lee D. Spate, Miguel E Ortiz Bezara, Camilla E Hippee, Guillermo S Romano Ibarra, Keyan Zarei, Patrick D Allen, Steven E Mather, J. Adam Goeken, Mahmoud H. Abou Alaiwa, Linda S. Powers, Anthony J. Fischer, Kristin M. Whitworth, David A. Stoltz, Melissa Samuel, David K. Meyerholz, Mallory R. Stroik, Eric A. Hoffman, Nicholas D. Gansemer, Brian J Goodell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86286ac82a3812b35bfef1950a736ec
https://doi.org/10.7554/elife.59653.sa2
https://doi.org/10.7554/elife.59653.sa2
Autor:
Thomas B. Bair, Leah R. Reznikov, Michael J. Welsh, Nicholas L. Bormann, David A. Stoltz, Shin-Ping Kuan, David K. Meyerholz, Margaret P. Price, Yan-Shin J. Liao, Mahmoud H. Abou Alaiwa
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 315:L133-L148
Mainstay therapeutics are ineffective in some people with asthma, suggesting a need for additional agents. In the current study, we used vagal ganglia transcriptome profiling and connectivity mapping to identify compounds beneficial for alleviating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e229436c64a5f273881d8bf24950a611
https://doi.org/10.1152/ajplung.00557.2017
https://doi.org/10.1152/ajplung.00557.2017