Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Mahmoud H Elbatreek"'
1
Akademický článek
NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype.
Autor: Mahmoud H Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M H Schiffers, Ger M Janssen, Pamela W M Kleikers, Anil Wipat, Jan Baumbach, Jo G R De Mey, Harald H H W Schmidt
Publikováno v: PLoS Biology, Vol 18, Iss 11, p e3000885 (2020)
Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10 cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves impaired endothelium-dependent vasodilation through reactive oxygen s
Externí odkaz: https://doaj.org/article/59e3c69f9059443b811c06990062c088
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2
Akademický článek
Casuarina glauca branchlets’ extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies
Autor: Maged E. Mohamed, Azza M. El-Shafae, Eman Fikry, Samar S. Elbaramawi, Mahmoud H. Elbatreek, Nora Tawfeek
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
Ulcerative colitis (UC) is an inflammatory bowel disease that is often resistant to current treatment options, leading to a need for alternative therapies. Herbal products have shown promise in managing various conditions, including UC. However, the
Externí odkaz: https://doaj.org/article/e1bbd7ecf21b411684b61fe394d9f2f2
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3
Akademický článek
Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis
Autor: Florence Ho, Anna M. D. Watson, Mahmoud H. Elbatreek, Pamela W. M. Kleikers, Waheed Khan, Karly C. Sourris, Aozhi Dai, Jay Jha, Harald H. H. W. Schmidt, Karin A. M. Jandeleit-Dahm
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Atherosclerosis and its complications are major causes of cardiovascular morbidity and death. Apart from risk factors such as hypercholesterolemia and inflammation, the causal molecular mechanisms are unknown. One proposed causal mechanism i
Externí odkaz: https://doaj.org/article/f170c8d5791c4835a6d1bf01a380065d
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4
Akademický článek
Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine against Klebsiella pneumoniae and Pseudomonas aeruginosa coinfection
Autor: Ahmed M. Gouda, Mohamed A. Soltan, Khalid Abd-Elghany, Ashraf E. Sileem, Hanan M. Elnahas, Marwa Abdel-Monem Ateya, Mahmoud H. Elbatreek, Khaled M. Darwish, Hanin A. Bogari, Manar O. Lashkar, Mohammed M. Aldurdunji, Sameh S. Elhady, Tarek A. Ahmad, Ahmed Mohamed Said
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction:Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. aeruginosa) are the most common Gram-negative bacteria associated with pneumonia and coinfecting the same patient. Despite their high virulence, there is no effective v
Externí odkaz: https://doaj.org/article/993fb5119913403e9533700e0e4c237b
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5
Understanding (apo-) soluble guanylate cyclase allosterism and its therapeutic implications
Autor: Alexandra Petraina, Mahmoud H. Elbatreek, Christopher T. Neullens, Theodora Saridaki, Vu Thao-vi Dao, Ana I Casas, Harald HHW. Schmidt
Nitric oxide (NO) is a widely distributed gasotransmitter binding to the heme of soluble guanylate cyclase (sGC) to stimulate the formation of the second messenger cyclic GMP. In disease, two pathomechanisms can occur, scavenging of NO by reactive ox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::986bb97211be495af6c890cfdb570a3e
https://doi.org/10.14293/s2199-1006.1.sor-.ppw9ffl.v2
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7
On a revised pharmacology of apo-soluble guanylate cyclase and its therapeutic implications
Autor: Alexandra Petraina, Mahmoud H. Elbatreek, Christopher T. Neullens, Theodora Saridaki, Vu Thao-vi Dao, Ana I Casas, Harald HHW. Schmidt
Nitric oxide (NO) is a widely distributed gasotransmitter binding to the heme of soluble guanylate cyclase (sGC) to stimulate the formation of the second messenger cyclic GMP. In disease, two pathomechanisms can occur, scavenging of NO by reactive ox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a6612ca1d0239d606806ec8425b54d
https://doi.org/10.14293/s2199-1006.1.sor-.ppw9ffl.v1
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10
Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation
Autor: Harald H.H.W. Schmidt, Ulla G. Knaus, Mayra P. Pachado, Mahmoud H. Elbatreek, Christopher T. Neullens, Sebastian Altenhöfer, Vu Thao-Vi Dao, Ana I. Casas
Publikováno v: Free Radical Biology and Medicine, 148, 60-69. Elsevier Science
Free Radical Biology and Medicine
Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however, has failed in multiple clinical trials to provide patient benefit. Instead,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b1439084aae1f7e843ab4206f951aa
https://doi.org/10.1016/j.freeradbiomed.2019.12.038
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