Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mahmoud G Khalafalla"'
Autor:
Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem, Hidayatullah G. Munshi
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
To elicit effective antitumor responses, CD8+ T cells need to infiltrate tumors and sustain their effector function within the immunosuppressive tumor microenvironment (TME). Here, we evaluate the role of MNK activity in regulating CD8+ T cell infilt
Externí odkaz:
https://doaj.org/article/1a09d8a5ba8e4f9fab3e3efe9e16fad1
Autor:
Mahmoud G. Khalafalla, Lucas T. Woods, Kimberly J. Jasmer, Kevin Muñoz Forti, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel. Therefore, saliv
Externí odkaz:
https://doaj.org/article/a2dca1737cb34136b4dfa4310d80b2cd
Publikováno v:
Biochimica et biophysica acta. Reviews on cancer. 1877(3)
Despite recent advances in the treatment landscape for prostate cancer, many challenges still remain. A more profound understanding of prostate cancer pathogenesis and the underlying mechanisms is critical to developing novel therapeutics strategies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a4857496f2280f943825ae20c31a66
https://pubmed.ncbi.nlm.nih.gov/35483490
https://pubmed.ncbi.nlm.nih.gov/35483490
Autor:
Lucas T Woods, Jean M Camden, Farid G El-Sayed, Mahmoud G Khalafalla, Michael J Petris, Laurie Erb, Gary A Weisman
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123641 (2015)
Transforming growth factor-β (TGF-β) is a multi-functional cytokine with a well-described role in the regulation of tissue fibrosis and regeneration in the liver, kidney and lung. Submandibular gland (SMG) duct ligation and subsequent deligation in
Externí odkaz:
https://doaj.org/article/ef6716bf45674d6489c3c78a66c7d69e
Gα13 loss promotes tumor progression in the KPC transgenic mouse model of advanced pancreatic cancer
Autor:
Hidayatullah G. Munshi, Christina Spaulding, Mahmoud G. Khalafalla, Thao Pham, Mario A. Shields
SUMMARYGα13 transduces signals from G protein-coupled receptors. Gα13 is pro-tumorigenic in epithelial cancer cell lines, which contrasts with its tumor-suppressive function in transgenic mouse models of lymphomas. Here we show that while loss of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375c5a5528a095d2748376555aa21822
https://doi.org/10.1101/2021.03.15.435488
https://doi.org/10.1101/2021.03.15.435488
Autor:
Mahmoud G. Khalafalla, Thao Pham, Hidayatullah G. Munshi, Mario A. Shields, Christina Spaulding
Publikováno v:
Cancer Research. 81:PO-094
Gα13 transduces signals from G protein-coupled receptors. Gα13 is pro-tumorigenic in epithelial cancer cell lines, which contrasts with its tumor-suppressive function in transgenic mouse models of lymphomas. We investigated the role of Gα13 in pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9a40ed32c8c39797ae30cdcd435b44
https://doi.org/10.1158/1538-7445.panca21-po-094
https://doi.org/10.1158/1538-7445.panca21-po-094
Autor:
Hidayatullah G. Munshi, Mario A. Shields, Mahmoud G. Khalafalla, Christina Spaulding, David J. Bentrem, Thao Pham, Daniel R. Principe
Publikováno v:
Cancer Research. 81:PO-049
Background MAPK-interacting serine/threonine-protein kinase 1 and 2 (MNK1 and MNK2) are downstream effectors of the MEK/ERK and p38 MAPK pathways. Increased expression and activity of MNK kinases are linked to tumor growth and therapeutic resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9826973e0a7a30d9b9c6c36d750e41dc
https://doi.org/10.1158/1538-7445.panca21-po-049
https://doi.org/10.1158/1538-7445.panca21-po-049
Autor:
Mario A. Shields, Christina Spaulding, Anastasia E. Metropulos, Mahmoud G. Khalafalla, Thao N.D. Pham, Hidayatullah G. Munshi
Publikováno v:
Cell Reports. 38:110441
Gα13 transduces signals from G-protein-coupled receptors. While Gα13 functions as a tumor suppressor in lymphomas, it is not known whether Gα13 is pro-tumorigenic or tumor suppressive in genetically engineered mouse (GEM) models of epithelial canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca934e9573f66f19e8a5c94c65e528a
https://doi.org/10.1016/j.celrep.2022.110441
https://doi.org/10.1016/j.celrep.2022.110441
Autor:
Michael J. Petris, Lucas T. Woods, Jean M. Camden, Laurie Erb, Mahmoud G. Khalafalla, JL Ambrus, Gary A. Weisman
Publikováno v:
Oral Diseases. 24:761-771
OBJECTIVE: Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren’s syndrome, including sialadenitis and hyposalivation. The P2Y(2) receptor (P2Y(2)R) for extracellular ATP and UTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4517a8bf8199a8182286bc9b0360621d
https://doi.org/10.1111/odi.12823
https://doi.org/10.1111/odi.12823
Autor:
Mario A. Shields, Hidayatullah G. Munshi, Mahmoud G. Khalafalla, Christina Spaulding, Thao D.N. Pham
Publikováno v:
Cancer Research. 80:PO-060
We previously reported that Gα13 (Gna13), a member of the G12 heterotrimeric G proteins, is upregulated in pancreatic cancer patients and contributes to invasion in cancer cells in vitro. While other reports have demonstrated a tumor promoting funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf37c9195a80d447127e460425e60e72
https://doi.org/10.1158/1538-7445.panca20-po-060
https://doi.org/10.1158/1538-7445.panca20-po-060