Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mahmoud El Azzouny"'
Autor:
Hiroyuki Mori, Colleen E Dugan, Akira Nishii, Ameena Benchamana, Ziru Li, Thomas S Cadenhead, Arun K Das, Charles R Evans, Katherine A Overmyer, Steven M Romanelli, Sydney K Peterson, Devika P Bagchi, Callie A Corsa, Julie Hardij, Brian S Learman, Mahmoud El Azzouny, Joshua J Coon, Ken Inoki, Ormond A MacDougald
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3000988 (2021)
Although visceral adipocytes located within the body's central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at cooler te
Externí odkaz:
https://doaj.org/article/0a2c69a31868454387b35182f8affd1f
Autor:
Mahmoud El Azzouny, Melissa J. Longacre, Israr-ul H. Ansari, Robert T. Kennedy, Charles F. Burant, Michael J. MacDonald
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 980-987 (2016)
Objective: Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secr
Externí odkaz:
https://doaj.org/article/6f3c5388e8594e419be8953d195d26ab
Autor:
Colleen E. Dugan, Steven M. Romanelli, Ziru Li, Callie A.S. Corsa, Thomas S. Cadenhead, Brian S. Learman, Ormond A. MacDougald, Akira Nishii, Devika P. Bagchi, Hiroyuki Mori, Ken Inoki, Sydney K. Peterson, Ameena Benchamana, Katherine A. Overmyer, Julie Hardij, Arun K. Das, Charles R. Evans, Mahmoud El Azzouny
Although visceral adipocytes located within the body’s central core are maintained at ~37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell, and generally exist at cooler temperatures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa8c7229552af476b9e4059736f7798
https://doi.org/10.1101/2020.10.16.342220
https://doi.org/10.1101/2020.10.16.342220
Autor:
Jonathan H. Schatz, Mahmoud El-Azzouny, Charles F. Burant, Amit Dipak Amin, Nathanael G. Bailey, Gleb A. Bazilevsky, John K. Frederiksen, Santiago Schnell, Kaiyu Ma, James L. Riley, Megan S. Lim, Johnvesly Basappa, Yeqiao Zhou, Steven R. Hwang, Anagh A. Sahasrabuddhe, Kathryn E. Wellen, Kevin P. Conlon, Kojo S.J. Elenitoba-Johnson, Robert B. Faryabi, Venkatesha Basrur, Ronen Marmorstein, Jan M. Pawlicki, David L. Cookmeyer, Delphine Rolland
A fundamental requirement for growth of rapidly proliferating cells is metabolic adaptation to promote synthesis of biomass1. ATP citrate lyase (ACLY) is a critical enzyme responsible for synthesis of cytosolic acetyl-CoA, the key building component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed542fe418b17ad5f4209e1c1fe96cc8
https://doi.org/10.1101/2020.01.20.910752
https://doi.org/10.1101/2020.01.20.910752
The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
Autor:
Joshua J. Coon, Katherine A. Overmyer, Sydney K. Peterson, Akira Nishii, Ameena Benchamana, Hiroyuki Mori, Brian S. Learman, Devika P. Bagchi, Steven M. Romanelli, Callie A.S. Corsa, Thomas S. Cadenhead, Mahmoud El Azzouny, Charles R. Evans, Ken Inoki, Colleen E. Dugan, Arun K. Das, Ziru Li, Ormond A. MacDougald, Julie Hardij
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3000988 (2021)
PLoS Biology
PLoS Biology
Although visceral adipocytes located within the body’s central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at cooler
Autor:
Christopher T.M.B. Tom, Brent R. Martin, Mary J. Tanga, Katherine A. Gallagher, Charles F. Burant, Lori L. Olson, Mahmoud El-Azzouny, Charles R. Evans
Publikováno v:
Journal of Biological Chemistry. 292:4766-4769
Itaconic acid is an important metabolite produced by macrophages after stimulation with LPS. The role of itaconate in the inflammatory cascade is unclear. Here we used [13C]itaconate and dimethyl [13C]itaconate (DMI) to probe itaconate metabolism, an
Autor:
Melissa J. Longacre, Siriluck Wattanavanitchakorn, Israr H. Ansari, Michael J. MacDonald, Scott W. Stoker, Mahmoud El Azzouny, Sarawut Jitrapakdee
Publikováno v:
Archives of biochemistry and biophysics. 676
Pyruvate carboxylase (PC) is an anaplerotic enzyme that supplies oxaloacetate to mitochondria enabling the maintenance of other metabolic intermediates consumed by cataplerosis. Using liquid chromatography mass spectrometry (LC-MS) to measure metabol
Autor:
Mahmoud El-Azzouny, Katherine A. Gallagher, Andrew Kimball, Frank M. Davis, Anna Boniakowski, Amrita Joshi, Aaron denDekker, Charles F. Burant
Publikováno v:
Diabetes. 68
Macrophage (Mφ) plasticity, allowing the transition of Mφs from an inflammatory to a reparative phenotype, is critical for normal wound healing. In pathologic conditions, such as type 2 diabetes (T2D), wounds fail to heal due to impaired resolution
Monitoring cell secretions on microfluidic chips using solid-phase extraction with mass spectrometry
Autor:
Colleen E. Dugan, Sebastian D. Parlee, Charles R. Evans, Mahmoud El-Azzouny, Robert T. Kennedy, James P. Grinias
Publikováno v:
Analytical and Bioanalytical Chemistry. 409:169-178
Microfluidics is an enabling technology for both cell biology and chemical analysis. We combine these attributes with a microfluidic device for on-line solid-phase extraction (SPE) and mass spectrometry (MS) analysis of secreted metabolites from livi
Autor:
Charles F. Burant, Mahmoud El-Azzouny, Mary K. Treutelaar, Charles R. Evans, Robert T. Kennedy
Publikováno v:
Journal of Biological Chemistry. 289:13575-13588
Acute fatty acid (FA) exposure potentiates glucose-stimulated insulin secretion in β cells through metabolic and receptor-mediated effects. We assessed the effect of fatty acids on the dynamics of the metabolome in INS-1 cells following exposure to