Výsledky vyhledávání - "Mahmoud Darweesh"

Akademický článek

Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response

Autor: Arwa Ali, Paola Contreras, Mahmoud Darweesh, Leif Andersson, Chuan Jin, Magnus Essand, Di Yu

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102361- (2024)

Zinc finger CCCH containing 11A (ZC3H11A) is a stress-induced protein that is upregulated in various conditions such as heat shock and virus infection. It has also been reported to be upregulated in certain cancers. The aim of this study was to evalu

Externí odkaz: https://doaj.org/article/55543fdc6e9a4faa825fedbdf0d2410a

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Akademický článek

An innovative dual recognition aptasensor for specific detection of Staphylococcus aureus based on Au/Fe3O4 binary hybrid

Autor: Mohamed M. El-Wekil, Hamada Mohamed Halby, Mahmoud Darweesh, Mohamed E. Ali, Ramadan Ali

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract Pathogenic bacteria cause disease outbreaks and threaten human health, prompting the research on advanced detection assays. Herein, we developed a selective molecular imprinted aptasensor for sensitive and prompt quantitation of Staphylococc

Externí odkaz: https://doaj.org/article/ace1e0306ead42d5aad3181d8fa1e4a2

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Akademický článek

ZFP36 ring finger protein like 1 significantly suppresses human coronavirus OC43 replication

Autor: Tooba Momin, Andrew Villasenor, Amit Singh, Mahmoud Darweesh, Aditi Singh, Mrigendra Rajput

Publikováno v: PeerJ, Vol 11, p e14776 (2023)

CCCH-type zinc figure proteins (ZFP) are small cellular proteins that are structurally maintained by zinc ions. Zinc ions coordinate the protein structure in a tetrahedral geometry by binding to cystine-cystine or cysteines-histidine amino acids. ZFP

Externí odkaz: https://doaj.org/article/452c8ab60f804d7bb22c5655346f2f61

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Akademický článek

ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

Autor: Mahmoud Darweesh, Shady Younis, Zamaneh Hajikhezri, Arwa Ali, Chuan Jin, Tanel Punga, Soham Gupta, Magnus Essand, Leif Andersson, Göran Akusjärvi

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

ZC3H11A is a cellular protein associated with the transcription export (TREX) complex that is induced during heat-shock. Several nuclear-replicating viruses exploit the mRNA export mechanism of ZC3H11A protein for their efficient replication. Here we

Externí odkaz: https://doaj.org/article/61de2642722146158d6438f20a278063

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Akademický článek

Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation

Autor: Mahmoud Darweesh, Wael Kamel, Mikhail A. Gavrilin, Göran Akusjärvi, Catharina Svensson

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLR

Externí odkaz: https://doaj.org/article/60ee45bf83e84c6f84af9ce2810e095d

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Akademický článek

Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections

Autor: Zamaneh Hajikhezri, Mahmoud Darweesh, Göran Akusjärvi, Tanel Punga

Publikováno v: Viruses, Vol 12, Iss 11, p 1322 (2020)

The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control di

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Akademický článek

Synthesis, Structure, and Function of Human Adenovirus Small Non-Coding RNAs

Autor: Tanel Punga, Mahmoud Darweesh, Göran Akusjärvi

Publikováno v: Viruses, Vol 12, Iss 10, p 1182 (2020)

Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple r

Externí odkaz: https://doaj.org/article/85dddd33a8cb46d79b76396683f50754

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Structural characterization of a Thorarchaeota profilin indicates eukaryotic-like features but with an extended N-terminus

Autor: Celestine N. Chi, Sandra Lara, Mahmoud Darweesh, Ravi Teja Inturi

The emergence of the first eukaryotic cell was preceded by evolutionary events which are still highly debatable. Recently, comprehensive metagenomics analysis has uncovered that the Asgard super-phylum is the closest yet known archaea host of eukaryo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b961e3287f10c04cab6868b0f89c3a15
https://doi.org/10.1101/2021.08.06.455371