Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mahmoud A. S. Abdelhamid"'
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology. Recently ther
Externí odkaz:
https://doaj.org/article/b52a26d65c7b41eea2950237367ea4a5
Autor:
Alessia Pagano, Nunzia Iaccarino, Mahmoud A. S. Abdelhamid, Diego Brancaccio, Emanuele U. Garzarella, Anna Di Porzio, Ettore Novellino, Zoë A. E. Waller, Bruno Pagano, Jussara Amato, Antonio Randazzo
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
G-quadruplex (G4) and i-motif (iM) are four-stranded non-canonical nucleic acid structural arrangements. Recent evidences suggest that these DNA structures exist in living cells and could be involved in several cancer-related processes, thus represen
Externí odkaz:
https://doaj.org/article/d5d9b9c180dd4bdfb7a4144f37137c04
Autor:
Michael Darcy, Kyle Crocker, Yuchen Wang, Jenny V. Le, Golbarg Mohammadiroozbahani, Mahmoud A. S. Abdelhamid, Timothy D. Craggs, Carlos E. Castro, Ralf Bundschuh, Michael G. Poirier
Publikováno v:
ACS Nano. 16:5682-5695
The ability to apply and measure high forces (gt;10 pN) on the nanometer scale is critical to the development of nanomedicine, molecular robotics, and the understanding of biological processes such as chromatin condensation, membrane deformation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72515b4f03fad5cfb34386cfda1e30b6
https://doi.org/10.1021/acsnano.1c10698
https://doi.org/10.1021/acsnano.1c10698
Autor:
Hanna K. Maliszewska, Mahmoud A. S. Abdelhamid, María J. Marín, Zoë A. E. Waller, María Paz Muñoz
The constant need for novel drugs has prompted the scientific community to explore alternative structures to natural products and small and medium size organic compounds used in classic medicinal and pharmaceutical chemistry. Since the discovery of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3e865bc8a9509d6286315bc4f8935a
https://ueaeprints.uea.ac.uk/id/eprint/91827/
https://ueaeprints.uea.ac.uk/id/eprint/91827/
Autor:
Mahmoud A. S. Abdelhamid, Nicole M. Smith, Melanie C Grigg, Zoë A. E. Waller, Michelle O Ehiabor, Kelly L. Irving, Elisé P. Wright
Publikováno v:
Nucleic Acids Research
i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As these structures are composed of cytosine, they are potential sites for epigenetic modification. In addition to 5-methyl- and 5-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e2239fe6770170f97d617be589752d
https://doi.org/10.1093/nar/gkz1082
https://doi.org/10.1093/nar/gkz1082
Autor:
Georgy Y Nadysev, George V. Zatonsky, Eugene E Bykov, Pin Ju Chueh, Zoë A. E. Waller, Alexander S. Tikhomirov, Andrey E. Shchekotikhin, Mahmoud A. S. Abdelhamid
Publikováno v:
Journal of natural products. 84(5)
Heliomycin (also known as resistomycin) is an antibiotic with a broad spectrum of biological activities. However, low aqueous solubility and poor knowledge of its chemical properties have limited the development of this natural product. Here, we pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c289bf57d22c074a823a30bb2aa9383a
https://pubmed.ncbi.nlm.nih.gov/33974416
https://pubmed.ncbi.nlm.nih.gov/33974416
Autor:
Camille Amparo, Joyce Murata-Collins, Zoë A. E. Waller, Flavia Pichiorri, Mahmoud A. S. Abdelhamid, Jarrod Clark, Steven S. Smith, Victoria Bedell, Emily F. Warner, Marianna Martella
Background Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment. Materials and methods We developed a cloning procedure designed to recove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b35d1715f9daef035e486397bd1b001
https://europepmc.org/articles/PMC7078840/
https://europepmc.org/articles/PMC7078840/
Autor:
Andrew J. Gates, Mahmoud A. S. Abdelhamid, Zoë A. E. Waller, Myles R. Cheesman, László Fábián, Colin J. Macdonald
Publikováno v:
Nucleic Acids Research
Previous computational studies have shown that Cu+ can act as a substitute for H+ to support formation of cytosine (C) dimers with similar conformation to the hemi-protonated base pair found in i-motif DNA. Through a range of biophysical methods, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d105ba4db271b87fc53840987d3d63
https://doi.org/10.1093/nar/gky390
https://doi.org/10.1093/nar/gky390
Publikováno v:
Biochemistry. 58(4)
Numerous studies have been published stressing the importance of finding ligands that can bind specifically to DNA secondary structures. Several have identified ligands that are presented as having specific binding to the G-quadruplex; however, these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997f6153a9bcbf87aa86d70420c9c980
https://pubmed.ncbi.nlm.nih.gov/30350580
https://pubmed.ncbi.nlm.nih.gov/30350580
Autor:
Minglei Yang, Huakun Zhang, Susan Duncan, Lin Huang, Mahmoud A. S. Abdelhamid, Yueying Zhang, Philip N. Benfey, Zoë A. E. Waller, Xiaofei Yang, Yiliang Ding
Publikováno v:
Nucleic Acids Research
Liquid–liquid phase separation plays an important role in a variety of cellular processes, including the formation of membrane-less organelles, the cytoskeleton, signalling complexes, and many other biological supramolecular assemblies. Studies on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b746cb70dbe735f16bdfc4007710ae08