Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mahmoud A. Bassal"'
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors generate an RNA-based platform to neutralize the major epigenetic player DNMT1. Using this targeted approach, aberrant DNA methylation in cancer can be corrected.
Externí odkaz:
https://doaj.org/article/1ac7b00822ad42efaffe5d498c64c726
Autor:
Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica K. Evans, Meritxell Alberich-Jordà, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including
Externí odkaz:
https://doaj.org/article/028cca4501134f47a69fa8a2baa9c31b
Autor:
Hiro Tatetsu, Miho Watanabe, Jun Liu, Kenji Tokunaga, Eisaku Iwanaga, Yoshihiro Komohara, Emily Thrash, Mahmoud A. Bassal, Masao Matsuoka, Daniel G. Tenen, Li Chai
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 8, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/099f8f72f1da49b2a589a82379113b48
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Bernard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mitochondrial metabolism has been associated with tumourigenesis in acute myeloid leukaemia (AML) and currently considered as a potential therapeutic target. Here, the authors show, in patients with AML, that germline mutations in mitochondrial compl
Externí odkaz:
https://doaj.org/article/80997f20894a4c6ab09d4081863d91de
Autor:
Giorgia Maroni, Mahmoud A. Bassal, Indira Krishnan, Chee Wai Fhu, Virginia Savova, Rapolas Zilionis, Valerie A. Maymi, Nicole Pandell, Eva Csizmadia, Junyan Zhang, Barbara Storti, Julio Castaño, Riccardo Panella, Jia Li, Corinne E. Gustafson, Sam Fox, Rachel D. Levy, Claire V. Meyerovitz, Peter J. Tramontozzi, Kimberly Vermilya, Assunta De Rienzo, Stefania Crucitta, Daniela S. Bassères, Marla Weetall, Art Branstrom, Alessandra Giorgetti, Raffaele Ciampi, Marzia Del Re, Romano Danesi, Ranieri Bizzarri, Henry Yang, Olivier Kocher, Allon M. Klein, Robert S. Welner, Raphael Bueno, Maria Cristina Magli, John G. Clohessy, Azhar Ali, Daniel G. Tenen, Elena Levantini
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Maroni, Bassal, Krishnan et al. characterise human non-small cell lung cancer (NSCLC) carrying Kras-mutations by single-cell RNA sequencing. They identify a tumour-specific population that is conserved in mice and responds to the drug, PTC596, which
Externí odkaz:
https://doaj.org/article/2b905167a9874951ba0ccb3de9335972
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Benard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/358e6495258e4f5ea0b4793e347e5337
Autor:
Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao-Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108181- (2020)
Summary: Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression. Labile heme and Hx levels are inversely correlated in the plasma of patients with prostat
Externí odkaz:
https://doaj.org/article/76000eec6b3949338a7ea5bf4b5f4c5a
Autor:
Simone Ummarino, Clinton Hausman, Giulia Gaggi, Lucrezia Rinaldi, Mahmoud A. Bassal, Yanzhou Zhang, Andy Joe Seelam, Ikei S. Kobayashi, Marta Borchiellini, Alexander K. Ebralidze, Barbara Ghinassi, Bon Q. Trinh, Susumu S. Kobayashi, Annalisa Di Ruscio
Publikováno v:
Cells, Vol 10, Iss 11, p 2986 (2021)
Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms. Consequently, imbalance in the nutritional intake is able to dysregulate the epigenetic profile and dr
Externí odkaz:
https://doaj.org/article/95f6f216f4354e839427510a4d5e52e5
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated oncogenic pathway in triple-negative breast cancer (TNBC), a highly aggressive tumor subtype encompassing ∼15% of breast cancers and which possesses no targeted therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbcc39c7e0544b1c8d7a23920e4ebdb
https://doi.org/10.1073/pnas.2203180119
https://doi.org/10.1073/pnas.2203180119
Autor:
Sweta B. Patel, Jake Y. Chen, Zongliang Yue, Victor M. Darley-Usmar, Brittany L. Crown, Ravi Bhatia, Daniel G. Tenen, Rui Lu, Li Ying, Paul Brent Ferrell, Davide Stefanoni, Ashley T. Hoang, Samuel L. Wolock, Danielle Tenen, Travis Nemkov, Angelo D'Alessandro, Robert S. Welner, Jihye Park, Henry Yang, Valeriya Kuznetsova, Gloria A. Benavides, Mahmoud A. Bassal, Virginia Camacho, Victoria R. Matkins
Publikováno v:
Leukemia
Leukemic stem cells (LSCs) can acquire non-mutational resistance following drug treatment leading to therapeutic failure and relapse. However, oncogene-independent mechanisms of drug persistence in LSCs are incompletely understood, which is the prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f73c6ca4abbc6e8ae6be675a382c70d
https://doi.org/10.1038/s41375-021-01315-0
https://doi.org/10.1038/s41375-021-01315-0