Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mahlet A. Woldeyes"'
Autor:
Amjad A. Chowdhury, Neha Manohar, Marta A. Witek, Mahlet A. Woldeyes, Ranajoy Majumdar, Ken K. Qian, William D. Kimball, Shifeng Xu, Alfredo Lanzaro, Thomas M. Truskett, Keith P. Johnston
Publikováno v:
Molecular Pharmaceutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a31c515821aaef29e3bc232ece18943d
https://doi.org/10.1021/acs.molpharmaceut.3c00023
https://doi.org/10.1021/acs.molpharmaceut.3c00023
Publikováno v:
Pharmaceutical research. 38(11)
Protein solubility is an important attribute of pharmaceutical monoclonal antibody (MAb) formulations, particularly at high MAb concentrations. PEG-induced protein precipitation has been routinely used to assess protein solubility. To provide insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cab516c6fdd10fe632750aa790014c4
https://pubmed.ncbi.nlm.nih.gov/34647231
https://pubmed.ncbi.nlm.nih.gov/34647231
Publikováno v:
Molecular pharmaceutics. 17(12)
Protein solution viscosity (η) as a function of temperature was measured at a series of protein concentrations under a range of formulation conditions for two monoclonal antibodies (MAbs) and a globular protein (aCgn). Based on theoretical arguments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c322907b67c9b789c8313b485c600e
https://pubmed.ncbi.nlm.nih.gov/33170708
https://pubmed.ncbi.nlm.nih.gov/33170708
Autor:
Danielle L. Leiske, Eric M. Furst, Christopher J. Roberts, William J. Galush, Mahlet A. Woldeyes, Lilian Lam Josephson
Publikováno v:
Molecular Pharmaceutics. 15:4745-4755
Solution viscosities (η) and protein-protein interactions (PPI) of three monoclonal antibodies (mAb-A, mAb-B, mAb-C), two bispecific antibodies (BsAb-A/B, BsAb-A/C), and two 1:1 binary mixtures (mAb-A + mAb-B and mAb-A + mAb-C) were measured. mAb-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee7ff0e376b0822ef608a480df1ccc1
https://doi.org/10.1021/acs.molpharmaceut.8b00706
https://doi.org/10.1021/acs.molpharmaceut.8b00706
Publikováno v:
The Journal of Physical Chemistry B. 121:4756-4767
Protein interactions of α-chymotrypsinogen A (aCgn) were quantified using light scattering from low to high protein concentrations. Static light scattering (SLS) was used to determine the excess Rayleigh ratio (Rex) and osmotic second virial coeffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a12598e25908b6db46b876c9ef13524
https://doi.org/10.1021/acs.jpcb.7b02183
https://doi.org/10.1021/acs.jpcb.7b02183
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2039
Static and dynamic (laser) light scattering (SLS and DLS, respectively) can be used to measure the so-called weak or colloidal protein-protein interactions in solution from low to high protein concentrations (c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2849888ea532c474104911ba08caf65b
https://pubmed.ncbi.nlm.nih.gov/31342416
https://pubmed.ncbi.nlm.nih.gov/31342416
Publikováno v:
Methods in Molecular Biology ISBN: 9781493996773
Static and dynamic (laser) light scattering (SLS and DLS, respectively) can be used to measure the so-called weak or colloidal protein-protein interactions in solution from low to high protein concentrations (c2). This chapter describes a methodology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d39cdb6183779a4f0e3e532710c684
https://doi.org/10.1007/978-1-4939-9678-0_2
https://doi.org/10.1007/978-1-4939-9678-0_2
Autor:
Bernhardt L. Trout, Kristen E. Whaley, Ying Diao, Mahlet A. Woldeyes, T. Alan Hatton, Patrick S. Doyle, Matthew E. Helgeson, Allan S. Myerson
Publikováno v:
Journal of the American Chemical Society. 134:673-684
Although nanoporous materials have been explored for controlling crystallization of polymorphs in recent years, polymorphism in confined environments is still poorly understood, particularly from a kinetic perspective, and the role of the local struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a942cf9b3a6afade41fec32c16dcc3c4
https://doi.org/10.1021/ja210006t
https://doi.org/10.1021/ja210006t