Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mahitha Shree Anandachar"'
Autor:
Aditi Sharma, Sajan Chandrangadhan Achi, Stella-Rita Ibeawuchi, Mahitha Shree Anandachar, Hobie Gementera, Uddeep Chaudhury, Fatima Usmani, Kevin Vega, Ibrahim M Sayed, Soumita Das
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTMicrobial sensors play an essential role in maintaining cellular homoeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases. Recently we have confirmed that ELMO
Externí odkaz:
https://doaj.org/article/f4bf4242bfa6473fb93b6a1a9e9d67bd
Autor:
Gajanan D. Katkar, Ibrahim M. Sayed, Mahitha Shree Anandachar, Vanessa Castillo, Eleadah Vidales, Daniel Toobian, Fatima Usmani, Joseph R. Sawires, Geoffray Leriche, Jerry Yang, William J. Sandborn, Soumita Das, Debashis Sahoo, Pradipta Ghosh
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-21 (2022)
A Boolean network explorer (BoNE) computational algorithm was used to identify a dual agonist of the nuclear receptors PPARα and PPARγ that may be therapeutic in treating inflammatory bowel disease.
Externí odkaz:
https://doaj.org/article/6d8b2f48ab0d4bd780c79d0b4d7cbf15
Autor:
Daniella T. Vo, MacKenzie R. Fuller, Courtney Tindle, Mahitha Shree Anandachar, Soumita Das, Debashis Sahoo, Pradipta Ghosh
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103121- (2021)
Summary: Transient depletion of the transcription elongation factor SPT6 in the keratinocyte has been recently shown to inhibit epidermal differentiation and stratification; instead, they transdifferentiate into a gut-like lineage. We show here that
Externí odkaz:
https://doaj.org/article/8d3b6b73cb2444a69efa994baaed2d91
Autor:
Ibrahim M Sayed, Stella-Rita Ibeawuchi, Dominique Lie, Mahitha Shree Anandachar, Rama Pranadinata, Manuela Raffatellu, Soumita Das
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Host engulfment protein ELMO1 generates intestinal inflammation following internalization of enteric bacteria. In Shigella, bacterial effector IpgB1 interacts with ELMO1 and promotes bacterial invasion. IpgB1 belongs to the WxxxE effector family, a m
Externí odkaz:
https://doaj.org/article/d7b9dca0753d4394bab8eb20083824c4
Autor:
Mahitha Shree Anandachar, Agyekum Boadi, Saptarshi Sinha, Suchismita Roy, Stella-Rita Ibeawuchi, Hobie Gementera, Alicia Amamoto, Gajanan D. Katkar, Pradipta Ghosh
Publikováno v:
bioRxiv
Macrophages clear infections by engulfing and digesting pathogens within phagolysosomes. Pathogens escape this fate by engaging in a molecular arms race; they useWxxxEmotif- containing “effector” proteins to subvert the host cells they invade and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cd39f12e2908084d36027a6046725d
https://europepmc.org/articles/PMC10104235/
https://europepmc.org/articles/PMC10104235/
Autor:
Aditi Sharma, Sajan Chandrangadhan Achi, Stella-Rita Ibeawuchi, Mahitha Shree Anandachar, Hobie Gementera, Uddeep Chaudhury, Fatima Usmani, Kevin Vega, Ibrahim M Sayed, Soumita Das
Publikováno v:
Virulence, vol 14, iss 1
Microbial sensors play an essential role in maintaining cellular homeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases. Recently, we have shown that cytosolic sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428e6127e880936a908e52380ce0e5e5
https://doi.org/10.1101/2022.07.09.499433
https://doi.org/10.1101/2022.07.09.499433
Autor:
Gajanan D. Katkar, Mahitha Shree Anandachar, Saptarshi Sinha, Stella-Rita Ibeawuchi, Celia R. Espinoza, Jane Coates, Yashaswat S. Malhotra, Madhubanti Mullick, Vanessa Castillo, Daniella T. Vo, Debashis Sahoo, Pradipta Ghosh
/SUMMARYSensing of pathogens by Nucleotide oligomerization domain (NOD)-like 2 receptor (NOD2) induces a protective inflammatory response that coordinates bacterial clearance. Polymorphisms in NOD2 impair bacterial clearance, leading to chronic gut i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098d07f6f765d6df8925480dbe5cbb75
https://doi.org/10.1101/2022.04.26.489574
https://doi.org/10.1101/2022.04.26.489574
Autor:
Vanessa Castillo, Pradipta Ghosh, Irina Kufareva, Gajanan D. Katkar, Julian Tam, Joshua Olson, Jane Coates, Yogitha Chareddy, Lee Swanson, Mahitha Shree Anandachar, Rama F. Pranadinata, Victor Nizet, Soumita Das
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 43
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory response; controlled responses confer immunity but uncontrolled responses cause harm. Here we define how a multimodular scaffold, GIV (a.k.a. Girdin), titrates such inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6613b7d5b6d6924e36885b16b3be3c08
https://doi.org/10.1073/pnas.2011667117
https://doi.org/10.1073/pnas.2011667117
Autor:
Gajanan D. Katkar, Ibrahim M. Sayed, Mahitha Shree Anandachar, Vanessa Castillo, Eleadah Vidales, Daniel Toobian, Fatima Usmani, Joseph R. Sawires, Geoffray Leriche, Jerry Yang, William J. Sandborn, Soumita Das, Debashis Sahoo, Pradipta Ghosh
Publikováno v:
Communications biology, vol 5, iss 1
A computational platform, Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a05dfab3f70f6f07ff0fd833adb6ba
https://pubmed.ncbi.nlm.nih.gov/35288651
https://pubmed.ncbi.nlm.nih.gov/35288651
Autor:
Mahitha Shree Anandachar, Stella-Rita Ibeawuchi, Rama F. Pranadinata, Manuela Raffatellu, Ibrahim M Sayed, Dominique Lie, Soumita Das
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes
article-version (VoR) Version of Record
BackgroundHost engulfment protein ELMO1 generates intestinal inflammation following internalization of enteric bacteria. In Shigella, bacterial effector IpgB1 interacts with ELMO1 and promotes bacterial invasion. IpgB1 belongs to the WxxxE effector f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a738eb3abf18db1fedb8a4d63ba48585
https://doi.org/10.1101/2021.06.07.447447
https://doi.org/10.1101/2021.06.07.447447