Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mahindra Makhija"'
Autor:
David Merberg, Rodney Moreland, Zhenqiang Su, Bin Li, Bob Crooker, Kathleen Palmieri, Simon W. Moore, Andrew Melber, Ruby Boyanapalli, Galen Carey, Mahindra Makhija
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
Introduction Acid α-glucosidase (GAA) is a lysosomal enzyme that hydrolyzes glycogen to glucose. Deficiency of GAA causes Pompe disease (PD), also known as glycogen storage disease type II. The resulting glycogen accumulation causes a spectrum of di
Externí odkaz:
https://doaj.org/article/13dc94d36c43479d9ec57ece63a1b359
Autor:
Devin K. Binder, Carrie R. Jonak, Jacqueline A. Barbosa, Manbir S. Sandhu, Samantha A. Assad, Mahindra Makhija
Publikováno v:
Neurotherapeutics
Fragile X syndrome (FXS) is a genetic neurodevelopmental syndrome characterized by increased anxiety, repetitive behaviors, social communication deficits, delayed language development, and abnormal sensory processing. Recently, we have identified ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8065c1a747a19a6d24326cc3855f8cb1
https://doi.org/10.1007/s13311-021-01005-w
https://doi.org/10.1007/s13311-021-01005-w
Autor:
Keiko Uga, Jonathan Gilley, Xiuna Yang, Takashi Hoshino, Michael P. Coleman, Robert Adalbert, Mahindra Makhija, Christina Antoniou, Akira Kaieda, Andrea Loreto
Publikováno v:
ACS Chem Neurosci
Disruption of axonal transport causes a number of rare, inherited axonopathies and is heavily implicated in a wide range of more common neurodegenerative disorders, many of them age-related. Acetylation of α-tubulin is one important regulatory mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077b1ab5a82d9aa8c48d929ce4c342d5
https://doi.org/10.1021/acschemneuro.9b00338
https://doi.org/10.1021/acschemneuro.9b00338
Autor:
Samantha A. Assad, Jacqueline A. Barbosa, Mahindra Makhija, Manbir S. Sandhu, Devin K. Binder, Carrie R. Jonak
Publikováno v:
Neurotherapeutics. 18:1427-1427
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66d25f68049fd5862cf3947c3dd2cdc
https://doi.org/10.1007/s13311-021-01042-5
https://doi.org/10.1007/s13311-021-01042-5
Autor:
Steve Stroud, Jade Lyons Rimmer, Emanuela Ercolano, David A Hilton, Claire L. Adams, Allison Berger, C. Oliver Hanemann, Mahindra Makhija, Daniele Baiz, Sells Todd B
Publikováno v:
Cancers
Volume 12
Issue 7
Cancers, Vol 12, Iss 1744, p 1744 (2020)
Volume 12
Issue 7
Cancers, Vol 12, Iss 1744, p 1744 (2020)
Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7980ab8cd9ac09755ed4833108fd2cfa
https://doi.org/10.3390/cancers12071744
https://doi.org/10.3390/cancers12071744
Autor:
Mahindra Makhija, Heike Goebel, Edith Rolser, Torsten Dunkern, Waltraud Burckhard-Boer, Prashant S. Kharkar, Arati Prabhu, Premkumar Arumugam
Publikováno v:
Journal of Computer-Aided Molecular Design. 26:1277-1292
IMPDH (Inosine 5'-monophosphate dehydrogenase) catalyzes a rate-limiting step in the de novo biosynthesis of guanine nucleotides. IMPDH inhibition in sensitive cell types (e.g., lymphocytes) blocks proliferation (by blocking RNA and DNA synthesis as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffa8a5b62455d534b0438dac58a531c
https://doi.org/10.1007/s10822-012-9615-5
https://doi.org/10.1007/s10822-012-9615-5