Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mahidi Mardini"'
Publikováno v:
Oxford Medical Case Reports
Autor:
John W. Funder, Thi Yen Loan Le, David J. Handelsman, Anastasia S. Mihailidou, Anthony W. Ashton, Mahidi Mardini, Peter G. Stanton
Publikováno v:
Endocrinology. 155:568-575
Age-specific incidence of ischemic heart disease in men is higher than in women, although women die more frequently without previous symptoms; the molecular mechanism(s) are poorly understood. Most studies focus on protection by estrogen, with less a
Autor:
Thi Yen Loan Le, Anastasia S. Mihailidou, Viive M. Howell, Anthony W. Ashton, John W. Funder, Mahidi Mardini
Publikováno v:
Hypertension. 59:1164-1169
Low-dose mineralocorticoid receptor antagonists reduce morbidity and mortality in patients with heart failure and myocardial infarction, despite normal plasma aldosterone levels. Since apoptosis plays an important role in heart failure and postinfarc
Publikováno v:
Journal of Diabetes and its Complications. 25:122-128
Hyperglycaemia at the time of acute myocardial infarction (AMI) is a predictor of survival and is associated with increased mortality and morbidity in patients with or without diabetes mellitus. On the other hand, insulin has been shown to reduce myo
Publikováno v:
Hypertension. 54:1306-1312
Myocardial ischemia-reperfusion leads to significant changes in redox state, decreased postischemic functional recovery, and cardiomyocyte apoptosis, with development and progression of heart failure. Ischemia-reperfusion in the isolated perfused rat
Autor:
Peter S. Hansen, Keld Kjeldsen, Helge H. Rasmussen, Mahidi Mardini, Anastasia S. Mihailidou, Henning Bundgaard
Publikováno v:
Circulation Research. 86:37-42
Abstract —Aldosterone upregulates the Na + -K + pump in kidney and colon, classical target organs for the hormone. An effect on pump function in the heart is not firmly established. Because the myocardium contains mineralocorticoid receptors, we ex
Publikováno v:
Heart, lungcirculation. 13(3)
Many cardiovascular events, including ventricular arrhythmias, display diurnal variability with a morning peak, and a less pronounced afternoon peak. Since the advent of multiprogrammable implantable cardioverter-defibrillators (ICDs), it has been po
Publikováno v:
Endocrinology. 145(2)
Aldosterone elevates Na+/K+/2Cl− cotransporter activity in rabbit cardiomyocytes within 15 min, an effect blocked by K-canrenoate and thus putatively mineralocorticoid receptor mediated. Increased cotransporter activity raises intracellular [Na+] s
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 40(2)
Elevated aldosterone levels induce a spironolactone-inhibitable decrease in cardiac sarcolemmal Na + -K + pump function. Because pump inhibition has been shown to contribute to myocyte hypertrophy, restoration of Na + -K + pump function may represent