Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Maheswarareddy Emani"'
Autor:
Yiming Zhou, Choah Kim, Juan Lorenzo B. Pablo, Fan Zhang, Ji Yong Jung, Li Xiao, Silvana Bazua-Valenti, Maheswarareddy Emani, Corey R. Hopkins, Astrid Weins, Anna Greka
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease
Externí odkaz:
https://doaj.org/article/63a32a6e578a4a1fb96f6f3d356e4283
Autor:
Ayshwarya Subramanian, Eriene-Heidi Sidhom, Maheswarareddy Emani, Katherine Vernon, Nareh Sahakian, Yiming Zhou, Maria Kost-Alimova, Michal Slyper, Julia Waldman, Danielle Dionne, Lan T. Nguyen, Astrid Weins, Jamie L. Marshall, Orit Rosenblatt-Rosen, Aviv Regev, Anna Greka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition i
Externí odkaz:
https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d
Autor:
Amy D. Westerling-Bui, Eva Maria Fast, Thomas W. Soare, Srinivasan Venkatachalan, Michael DeRan, Alyssa B. Fanelli, Sergii Kyrychenko, Hien Hoang, Grinal M. Corriea, Wei Zhang, Maolin Yu, Matthew Daniels, Goran Malojcic, Xin-Ru Pan-Zhou, Mark W. Ledeboer, Jean-Christophe Harmange, Maheswarareddy Emani, Thomas T. Tibbitts, John F. Reilly, Peter Mundel
Publikováno v:
Science Advances. 8
Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery. Current approaches for PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to animal models with unclear translata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40449dd6e041ef112e7753de2cea4d8c
https://doi.org/10.1126/sciadv.abj5633
https://doi.org/10.1126/sciadv.abj5633
Autor:
Corey R. Hopkins, Fan Zhang, Choah Kim, Juan Lorenzo B. Pablo, Astrid Weins, Li Xiao, Maheswarareddy Emani, Anna Greka, Ji Yong Jung, Yiming Zhou, Silvana Bazua-Valenti
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine, Vol 8 (2021)
Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of kidney disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6236b73a891739d1c3a7d50e3a99396
https://doi.org/10.3389/fmed.2021.721865
https://doi.org/10.3389/fmed.2021.721865
Autor:
Moran Dvela-Levitt, Maria Alimova, Stanislav Kmoch, Seth L. Alper, Eva Kohnert, Eriene Sidhom, Anthony J. Bleyer, Anna Greka, Maheswarareddy Emani
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ddb45bfa9bf4e1f836b18d430af673
https://doi.org/10.1096/fasebj.2021.35.s1.01518
https://doi.org/10.1096/fasebj.2021.35.s1.01518
Autor:
Keith Keller, Michelle Melanson, Choah Kim, Jillian L. Shaw, Luciene Ronco, Jamie L. Marshall, Katherine A. Vernon, Anna Greka, Juan Lorenzo B. Pablo, Seth L. Alper, Eriene-Heidi Sidhom, Florence F. Wagner, George C. Tsokos, Elizabeth J. Grinkevich, Moran Dvela-Levitt, Matthew Racette, Valeria Padovano, Julie Roignot, Frederick W.K. Tam, Abbe Clark, Ayshwarya Subramanian, Jean Santos, Alissa Campbell, Astrid Weins, Juan Gutierrez, Abhigyan Satyam, Andrew J.B. Watts, Stephen P. McAdoo, Maheswarareddy Emani, Silvana Bazua-Valenti, Estefanía Reyes-Bricio, Maria Kost-Alimova, Juliana Coraor, Brian T. Chamberlain, Patrick J. Byrne, Rebecca Thompson
Publikováno v:
Cell Reports Medicine
bioRxiv
bioRxiv
Drug repurposing is the only method capable of delivering treatments on the shortened time-scale required for patients afflicted with lung disease arising from SARS-CoV-2 infection. Mucin-1 (MUC1), a membrane-bound molecule expressed on the apical su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac05c8ae52c2a9ddd2eedf3972ff732d
http://hdl.handle.net/10044/1/83980
http://hdl.handle.net/10044/1/83980
Autor:
Alissa Campbell, Katherine A. Vernon, Rebecca Thompson, Anna Greka, Julie Roignot, Silvana Bazua-Valenti, Eriene-Heidi Sidhom, Florence F. Wagner, Seth L. Alper, Frederick W.K. Tam, Matthew Racette, Abbe Clark, Michelle Melanson, Ayshwarya Subramanian, Jean Santos, Choah Kim, Estefania Reyes Bricio, Astrid Weins, George C. Tsokos, Jillian L. Shaw, Elizabeth J. Grinkevich, Juliana Coraor, Andrew J. R. Watts, Lucienne V. Ronco, Juan Gutierrez, Keith Keller, Moran Dvela-Levitt, Maria Alimova, Maheswarareddy Emani, Juan Pablo, Abhigyan Satyam, Valeria Padovano, Stephen P. McAdoo, Brian T. Chamberlain, Jamie L. Marshall
Publikováno v:
Cell Reports Medicine
Summary Drug repurposing has the advantage of identifying potential treatments on a shortened timescale. In response to the pandemic spread of SARS-CoV-2, we took advantage of a high-content screen of 3,713 compounds at different stages of clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014b2c3625f75412ce10742b925a6461
https://doi.org/10.1101/2020.06.30.180380
https://doi.org/10.1101/2020.06.30.180380
Autor:
Wei Zhang, Michael DeRan, Goran Malojčić, Xin-Ru Pan-Zhou, Maheswarareddy Emani, Jean-Christophe Harmange, Alyssa B. Fanelli, Hien Hoang, Peter Mundel, John F. Reilly, Mark W. Ledeboer, Amy Westerling-Bui, Maolin Yu, Srinivasan Venkatachalan, Sergii Kyrychenko, Thomas T. Tibbitts, Eva Maria Fast, Thomas W. Soare, Grinal M. Corriea
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims A major challenge in drug discovery is gaining confidence in the human relevance of pre-clinical animal studies. While human iPSC-derived organoids offer exciting opportunities to address this, concerns about applicability and sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b0f85b8aa6784f9df0c3d73f0c2b00
https://doi.org/10.1093/ndt/gfaa139.so038
https://doi.org/10.1093/ndt/gfaa139.so038
Autor:
Anna Greka, Aviv Regev, Nareh Sahakian, Jamie L. Marshall, Katherine A. Vernon, Michal Slyper, Maria Kost-Alimova, Eriene-Heidi Sidhom, Orit Rozenblatt-Rosen, Lan Nguyen, Danielle Dionne, Ayshwarya Subramanian, Astrid Weins, Maheswarareddy Emani, Yiming Zhou, Julia Waldman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and reducing the generation of off-target cells remain an open challenge. Here, we profile four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1431e51cb4c8ce14c0aa310510202ed
https://doi.org/10.1038/s41467-019-13382-0
https://doi.org/10.1038/s41467-019-13382-0
Autor:
Deepankar Chakroborty, Jaana Hagström, Caj Haglund, Riku Klén, Camilla Böckelman, Laura L. Elo, Ari Ristimäki, Maheswarareddy Emani, Riitta Lahesmaa
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Cancer
BMC Cancer
Background Prognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities. Methods Gene expression data was analyzed from three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a1c0ef2a9587a5dff0333acd8e74e4
https://doi.org/10.1186/s12885-019-5952-2
https://doi.org/10.1186/s12885-019-5952-2