Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maheshinie Rajapaksha"'
Autor:
William E Burak, Himangshu S. Bose, Curtis E Lanier, Brian W Wheeler, Maheshinie Rajapaksha, Nicholas D Carbo, Elin M Hahn, Randy M. Whittal, Edward Perkins, Brendan Marshall, Elizabeth W Perry, Neal M Hall, Mikhail M Melomed
Publikováno v:
Mol Cell Biol
Estradiol is essential for the development of female sex characteristics and fertility. Postmenopausal women and breast cancer patients have high levels of estradiol. Aromatase catalyzes estradiol synthesis; however, the factors regulating aromatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14881120c67310d2d8bb9428818208d
https://doi.org/10.1128/mcb.00357-21
https://doi.org/10.1128/mcb.00357-21
Autor:
Trenton E. Banks, Maheshinie Rajapaksha, Li-Hui Zhang, Feng Bai, Ning-Ping Wang, Zhi-Qing Zhao
Publikováno v:
European Journal of Pharmacology. 927:175048
This study aims to investigate whether stabilization of glucagon-like peptide-1 (GLP-1) level reduces angiotensin II (Ang II)-induced cardiac fibrosis and -elevated blood pressure accompanying with inhibition of NADPH oxidase (NOX) expression and pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ce0ee6667e90309300cec848cac1a4
https://doi.org/10.1016/j.ejphar.2022.175048
https://doi.org/10.1016/j.ejphar.2022.175048
Autor:
Elizabeth W Perry, Madhuchanda Bose, Brendan Marshall, Himangshu S. Bose, Zhi-Qing Zhao, Maheshinie Rajapaksha, Walter L. Miller, Randy M. Whittal, Ning Ping Wang
Publikováno v:
J Pharmacol Exp Ther
Aldosterone, which regulates renal salt retention, is synthesized in adrenocortical mitochondria in response to angiotensin II. Excess aldosterone causes myocardial injury and heart failure, but potential intracardiac aldosterone synthesis has been c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8149ac3b6985c5a9ddbb9503c0b7b4e5
https://pubmed.ncbi.nlm.nih.gov/33757981
https://pubmed.ncbi.nlm.nih.gov/33757981
Autor:
Maheshinie Rajapaksha, Walter L. Miller, Zhi-Qing Zhao, Elizabeth W Perry, Randy M. Whittal, Brendan Marshall, Ning-Ping Wang, Himangshu S. Bose
Publikováno v:
Journal of the Endocrine Society
Aldosterone (Aldo) causes myocardial injury and fibrosis. While most Aldo is made by the adrenal zona glomerulosa; there have been controversial reports that Aldo is also synthesized in the heart; such myocardial synthesis of Aldo might contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5e6be6c2f9d0c6707b89dd227c344e
http://europepmc.org/articles/PMC7209277
http://europepmc.org/articles/PMC7209277
Autor:
Manoj Prasad, Maheshinie Rajapaksha, Brendan Marshall, Himangshu S. Bose, Elizabeth W Perry, Kevin J. Pawlak, Randy M. Whittal, Jasmeet Kaur
Publikováno v:
Molecular and Cellular Biology. 36:1032-1047
After cholesterol is transported into the mitochondria of steroidogenic tissues, the first steroid, pregnenolone, is synthesized in adrenal and gonadal tissues to initiate steroid synthesis by catalyzing the conversion of pregnenolone to progesterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41388fcaabfb2ff77bb81e1a1b9bece9
https://doi.org/10.1128/mcb.01107-15
https://doi.org/10.1128/mcb.01107-15
Publikováno v:
Journal of Electrostatics. 103:103406
We built an electrospinning apparatus that integrates conventional electrospinning components with an FDM 3D-printing configuration, including real-time 3-axis control to improve accuracy and precision in nanofiber deposition over conventional far-fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3c273d03eb3a4d1321b44315ed3a07
https://doi.org/10.1016/j.elstat.2019.103406
https://doi.org/10.1016/j.elstat.2019.103406
Publikováno v:
ACS Chemical Biology. 8:1000-1008
The steroidogenic enzyme 3-β hydroxysteroid dehydrogenase 2 (3βHSD2) mediates the conversion of pregnenolone to progesterone and dehydroepiandrosterone to androstenedione through both its dehydrogenase and isomerase activities, making it necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6eaed835f64ec7608fabe731c1b2bf
https://doi.org/10.1021/cb400052s
https://doi.org/10.1021/cb400052s
Autor:
Geneva A. DeMars, Vance L. Mack, Maheshinie Rajapaksha, James L. Thomas, Himangshu S. Bose, Joseph A. Majzoub
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(1)
In human adrenarche during childhood, the secretion of dehydroepiandrosterone (DHEA) from the adrenal gland increases due to its increased synthesis and/or decreased metabolism. DHEA is synthesized by 17α-hydroxylase/17,20-lyase, and is metabolized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bce9005cc3ae90ff83820ffee5e4835
https://pubmed.ncbi.nlm.nih.gov/25355646
https://pubmed.ncbi.nlm.nih.gov/25355646
Publikováno v:
Biochemistry. 52(41)
Although the mechanism by which the steroidogenic acute regulatory protein (StAR) promotes steroidogenesis has been studied extensively, it remains incompletely characterized. Because structural analysis has revealed a hydrophobic sterol-binding pock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c011c883af17cab09229387f774001
https://pubmed.ncbi.nlm.nih.gov/24053410
https://pubmed.ncbi.nlm.nih.gov/24053410
Autor:
Maheshinie, Rajapaksha, Scott, Lovell, Blythe E, Janowiak, Kiran K, Andra, Kevin P, Battaile, James G, Bann
Publikováno v:
Protein science : a publication of the Protein Society. 21(10)
The anthrax protective antigen (PA) binds to the host cellular receptor capillary morphogenesis protein 2 (CMG2) with high affinity. To gain a better understanding of how pH may affect binding to the receptor, we have investigated the kinetics of bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93c0624475532465b324d7ef7b3d5697
https://pubmed.ncbi.nlm.nih.gov/22855243
https://pubmed.ncbi.nlm.nih.gov/22855243