Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mahesh Ramamoorthy"'
Autor:
Marion Dejosez, Alessandra Dall’Agnese, Mahesh Ramamoorthy, Jesse Platt, Xing Yin, Megan Hogan, Ran Brosh, Abraham S. Weintraub, Denes Hnisz, Brian J. Abraham, Richard A. Young, Thomas P. Zwaka
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112505- (2023)
Summary: Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes that encode housekeeping funct
Externí odkaz:
https://doaj.org/article/8c6ebe16c9054ba39a8a57ba9441a0a9
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway. However, this approach has been limited by di
Externí odkaz:
https://doaj.org/article/9cf800e55b814e00a0a386369be81f2e
Supplementary Data from MDM2 Controls the Timely Expression of Cyclin A to Regulate the Cell Cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5015eb8767f213ce1d71c02b0619b552
https://doi.org/10.1158/1541-7786.22519303.v1
https://doi.org/10.1158/1541-7786.22519303.v1
Autor:
Aikaterini Voulgaridou, Yasmin Elgammal, Ammar Husami, Sana Emberesh, Katie Seu, Mahesh Ramamoorthy, Lisa Trump, Nathaniel Barasa, Adam S. Nelson, Robert B. Lorsbach, Laurel Romano, Nathan A. Salomonis, Wenying Zhang, Carolyn Lutzko, Theodosia A. Kalfa
Publikováno v:
Blood. 140:1234-1235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d94eb5863b67b2dbca16c86ced2160
https://doi.org/10.1182/blood-2022-166509
https://doi.org/10.1182/blood-2022-166509
Publikováno v:
Stem Cell Research, Vol 41, Iss, Pp-(2019)
Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway. However, this approach has been limited by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5659a85d5358e9c77be51928fda693
https://doi.org/10.1016/j.scr.2019.101617
https://doi.org/10.1016/j.scr.2019.101617
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells
Autor:
Susan Smith, Mahesh Ramamoorthy
Publikováno v:
Cancer Cell. 28(3):357-369
SummaryThe chromatin-remodeler ATRX is frequently lost in cancer cells that use ALT (alternative lengthening of telomeres) for telomere maintenance, but its function in telomere recombination is unknown. Here we show that loss of ATRX suppresses the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6135841a125f2e35a3ef6350a37c2dd8
Autor:
Venkateswarlu Popuri, Jingyan Tian, Peter Sykora, Vilhelm A. Bohr, Mahesh Ramamoorthy, Takashi Tadokoro, Deborah L. Croteau, Ivana Rybanska, David M. Wilson, Alfred May
Publikováno v:
Molecular Biology of the Cell
Five human RecQ helicases are involved in genome maintenance. RECQL5, one of the important members of this helicase family, is involved in DNA single-strand break repair and base excision DNA repair.
Human RECQL5 is a member of the RecQ helicase
Human RECQL5 is a member of the RecQ helicase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e884ad80991dc85b22612bcb37292f1
https://doi.org/10.1091/mbc.e12-02-0110
https://doi.org/10.1091/mbc.e12-02-0110
Autor:
Kevin G. Becker, Christopher A. Dunn, Vilhelm A. Bohr, Cindy Kasmer, Morten Scheibye-Knudsen, Yongqing Zhang, Peter Sykora, Deborah L. Croteau, Mahesh Ramamoorthy
Publikováno v:
Free Radical Biology and Medicine. 53:1371-1380
Alzheimer disease (AD) is a major health problem in the United States, affecting one in eight Americans over the age of 65. The number of elderly suffering from AD is expected to continue to increase over the next decade, as the average age of the U.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3889a3a9601a00f8171e4210037678ef
https://doi.org/10.1016/j.freeradbiomed.2012.07.018
https://doi.org/10.1016/j.freeradbiomed.2012.07.018
Autor:
Vilhelm A. Bohr, Parimal Karmakar, Dharmendra Kumar Singh, Venkateswarlu Popuri, Takashi Tadokoro, Deborah L. Croteau, Mahesh Ramamoorthy
Publikováno v:
DNA Repair. 11:624-635
RECQL5 is one of the five human RecQ helicases, involved in the maintenance of genomic integrity. While much insight has been gained into the function of the Werner (WRN) and Bloom syndrome proteins (BLM), little is known about RECQL5. We have analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0f9ad4e59dd9321b975158ef5631dc
https://doi.org/10.1016/j.dnarep.2012.05.001
https://doi.org/10.1016/j.dnarep.2012.05.001
Autor:
Marie L. Rossi, Chandrika Canugovi, William C. Copeland, Vilhelm A. Bohr, Rajesh Kasiviswanathan, Dharmendra Kumar Singh, Zheng Ming Wang, Jane Tian, Mansour Akbari, Deborah L. Croteau, Mahesh Ramamoorthy, Peter Sykora
Publikováno v:
Aging Cell. 11:456-466
RECQL4 is associated with Rothmund-Thomson Syndrome (RTS), a rare autosomal recessive disorder characterized by premature aging, genomic instability, and cancer predisposition. RECQL4 is a member of the RecQ helicase family, and has many similarities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecebb675793ae3881578e76098e2f338
https://doi.org/10.1111/j.1474-9726.2012.00803.x
https://doi.org/10.1111/j.1474-9726.2012.00803.x