Výsledky vyhledávání - "Mahesh Kathania."

Akademický článek

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation

Autor: Amir Kumar Singh, Ritesh Kumar, Jianyi Yin, John F. Brooks II, Mahesh Kathania, Sandip Mukherjee, Jitendra Kumar, Kevin P. Conlon, Venkatesha Basrur, Zhe Chen, Xianlin Han, Lora V. Hooper, Ezra Burstein, K. Venuprasad

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Th17 cells that produce Interleukin IL-17 are pathogenic in many human diseases, including inflammatory bowel disease, but are, paradoxically, essential for maintaining the integrity of the intestinal barrier in a non-inflammatory state. How

Externí odkaz: https://doaj.org/article/befedf1f83644092980fd717763deaa0

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Akademický článek

Wasting condition as a marker for severe disease in pediatric Crohn's disease

Autor: Wook Jin, MD, Dong-Hwa Yang, MD, Hann Tchah, MD, Kwang-An Kwon, MD, Jung-Ho Kim, MD, Su-Jin Jeong, MD, Ki-Baik Hahm, MD, Mahesh Kathania.

Publikováno v: Medicine, Vol 101, Iss 20, p e29296 (2022)

Abstract. Several studies have shown an association between sarcopenia and clinical outcomes in patients with Crohn's disease (CD). However, studies have shown different results, and the association between prognosis and wasting conditions in pediatr

Externí odkaz: https://doaj.org/article/239da0557ce342168774b5eff4253aac

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Akademický článek

Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function

Autor: Marco L Davila, Amir Kumar Singh, Elviche L Tsakem, Mahesh Kathania, Matthew J Riese

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)

Background Chimeric antigen receptor (CAR) T-cell therapy is an emerging option for cancer treatment, but its efficacy is limited, especially in solid tumors. This is partly because the CAR T cells become dysfunctional and exhausted in the tumor micr

Externí odkaz: https://doaj.org/article/46fdf68b933c4b81816f119845ff0132

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Akademický článek

SCGN deficiency results in colitis susceptibility

Publikováno v: eLife, Vol 8 (2019)

Inflammatory bowel disease (IBD) affects 1.5–3.0 million people in the United States. IBD is genetically determined and many common risk alleles have been identified. Yet, a large proportion of genetic predisposition remains unexplained. In this st

Externí odkaz: https://doaj.org/article/dd63f37bb27b42538ad9d4b24982c8fb

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Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

Autor: Mahesh Kathania, Ritesh Kumar, Elviche Taskem Lenou, Venkatesha Basrur, Arianne L. Theiss, Jonathan Chernoff, K. Venuprasad

Publikováno v: Cell Reports. 40:111345

Dysregulated interleukin-17 (IL-17) expression and its downstream signaling is strongly linked to inflammatory bowel diseases (IBDs). However, the molecular mechanisms by which the function of RORγt, the transcription factor of IL-17, is regulated r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd75b9c567b086ee50e03a37f023f6a
https://doi.org/10.1016/j.celrep.2022.111345

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Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function

Autor: Matthew J. Riese, K. Venuprasad, Ritesh Kumar, Arianne L. Theiss, Elviche L. Tsakem, Jitendra Kumar, Marco L. Davila, Mahesh Kathania, Amir Kumar Singh

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Journal for Immunotherapy of Cancer

BackgroundChimeric antigen receptor (CAR) T-cell therapy is an emerging option for cancer treatment, but its efficacy is limited, especially in solid tumors. This is partly because the CAR T cells become dysfunctional and exhausted in the tumor micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299f89e9b8bd48608abf6fa41389fcc8
https://jitc.bmj.com/content/9/1/e001688.full

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Akademický článek

Colonic immune stimulation by targeted oral vaccine.

Autor: Mahesh Kathania, Mojgan Zadeh, Yaíma L Lightfoot, Robert M Roman, Bikash Sahay, Jeffrey R Abbott, Mansour Mohamadzadeh

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e55143 (2013)

Currently, sufficient data exist to support the use of lactobacilli as candidates for the development of new oral targeted vaccines. To this end, we have previously shown that Lactobacillus gasseri expressing the protective antigen (PA) component of

Externí odkaz: https://doaj.org/article/c5d36c0cea254bee907826aef2a7410a

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IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5

Autor: Mahesh Kathania, T L Elviche, K. Venuprasad, Venkatesha Basrur, Minghui Zeng, Joydeep Paul, Arianne L. Theiss, A K Singh

Publikováno v: Mucosal Immunology. 11:427-436

Intestinal fibrosis is a major complication in inflammatory bowel diseases, but the regulatory mechanism that inhibits fibrosis remains unclear. Here we demonstrate that Itch-/-myofibroblasts express increased amounts of profibrotic collagen type I a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7563f2eb10b7677fb9c849b4d536760
https://doi.org/10.1038/mi.2017.53

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