Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mahesh Kasthuri"'
Autor:
Longhu Zhou, Hongwang Zhang, Chengwei Li, Coralie De Schutter, Ozkan Sari, Seema Mengshetti, Shaoman Zhou, Mahesh Kasthuri, Steven J. Coats, Raymond F. Schinazi, Franck Amblard
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1452-1461 (2021)
Externí odkaz:
https://doaj.org/article/e014eeef2887439f89555878649fce6a
Autor:
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1144 (2022)
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of N4-hydroxycytidine (NHC), was re
Externí odkaz:
https://doaj.org/article/5b28f39250b449959a136cc3c1d06f07
Autor:
Mahesh Kasthuri, Chengwei Li, Kiran Verma, Olivia Ollinger Russell, Lyndsey Dickson, Louise McCormick, Leda Bassit, Franck Amblard, Raymond F. Schinazi
Publikováno v:
Molecules, Vol 25, Iss 6, p 1258 (2020)
Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4′-chloromethyl-2′-deoxy-2′-fluoro nucleoside ALS-8112, wa
Externí odkaz:
https://doaj.org/article/3b5a12123fca47bdbd6f2c2dca092fc7
Autor:
Dharmeshkumar Patel, Bryan D. Cox, Mahesh Kasthuri, Seema Mengshetti, Leda Bassit, Kiran Verma, Olivia Ollinger‐Russell, Franck Amblard, Raymond F. Schinazi
Publikováno v:
Chem Biol Drug Des
Nucleoside analogs are the backbone of antiviral therapies. Drugs from this class undergo processing by host or viral kinases to form the active nucleoside triphosphate species that selectively inhibits the viral polymerase. It is the central hypothe
Autor:
Franck, Amblard, Julia C, LeCher, Ramyani, De, Shu Ling, Goh, Chengwei, Li, Mahesh, Kasthuri, Nicolas, Biteau, Longhu, Zhou, Zahira, Tber, Jessica, Downs-Bowen, Keivan, Zandi, Raymond F, Schinazi
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(9)
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of
Autor:
Franck Amblard, Dharmeshkumar Patel, Eleftherios Michailidis, Steven J. Coats, Mahesh Kasthuri, Nicolas Biteau, Zahira Tber, Maryam Ehteshami, Raymond F. Schinazi
Publikováno v:
European journal of medicinal chemistry. 240
More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been developed to manage and suppress HIV infection. Combinations of two to thre
Autor:
Franck Amblard, A. Louise McCormick, Olivia Ollinger Russell, Mahesh Kasthuri, Raymond F. Schinazi, Kiran Verma, Chengwei Li, Leda Bassit, Lyndsey Dickson
Publikováno v:
Molecules
Volume 25
Issue 6
Molecules, Vol 25, Iss 6, p 1258 (2020)
Volume 25
Issue 6
Molecules, Vol 25, Iss 6, p 1258 (2020)
Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4&prime
chloromethyl-2&prime
deoxy-2&prime
fluoro
chloromethyl-2&prime
deoxy-2&prime
fluoro
Autor:
Tamara R. McBrayer, Biing Y. Lin, Kiran Verma, Ozkan Sari, Olivia Ollinger Russell, Judy Pattassery, Yong Jiang, Maria Luz G. Pascual, Steven J. Coats, Seema Mengshetti, Leda Bassit, Jong Hyun Cho, Reuben Ovadia, Sijia Tao, Sam Lee, Mahesh Kasthuri, Robert A. Domaoal, Tony Whitaker, Coralie De Schutter, Raymond F. Schinazi, Longhu Zhou, Lothar Uher, Hongwang Zhang, Maryam Ehteshami, Franck Amblard
Publikováno v:
J Med Chem
Hepatitis C virus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of resistant virus, and are some of the most potent direct-acting agents with durable sustained virologic response in humans. Herein, we rep
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Publikováno v:
Synlett. 26:897-900
A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine deriv