Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mahesh K, Kaushik"'
Autor:
Yang Lin, Koustav Roy, Shuji Ioka, Rintaro Otani, Mao Amezawa, Yukiko Ishikawa, Yoan Cherasse, Mahesh K. Kaushik, Daniela Klewe-Nebenius, Li Zhou, Masashi Yanagisawa, Yo Oishi, Tsuyoshi Saitoh, Michael Lazarus
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Insomnia is associated with psychiatric illnesses such as bipolar disorder or schizophrenia. Treating insomnia improves psychotic symptoms severity, quality of life, and functional outcomes. Patients with psychiatric disorders are often d
Externí odkaz:
https://doaj.org/article/54ec9a2e91c5458794cfece383912e6b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Octacosanol, a component of various food materials, possesses prominent biological activities and functions. It fights against cellular stress by increasing glutathione level and thus scavenging oxygen reactive species. However, its anti-str
Externí odkaz:
https://doaj.org/article/f05c1581e20c4d48ae0ce5c4dd8d2f7a
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Social conflict is a major source of stress in humans. Animals also experience social conflicts and cope with them by stress responses that facilitate arousal and activate sympathetic and neuroendocrine systems. The effect of acute social defeat (SoD
Externí odkaz:
https://doaj.org/article/83dbc8d734e24602a1d237d755807a82
Autor:
Yoan Cherasse, Kosuke Aritake, Yo Oishi, Mahesh K. Kaushik, Mustafa Korkutata, Yoshihiro Urade
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Injection of nanomolar amounts of prostaglandin D2 (PGD2) into the rat brain has dose and time-dependent somnogenic effects, and the PGD2-induced sleep is indistinguishable from physiologic sleep. Sleep-inducing PGD2 is produced in the brain by lipoc
Externí odkaz:
https://doaj.org/article/72bca71227204d618ae52ae96e23f473
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172508 (2017)
Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative
Externí odkaz:
https://doaj.org/article/76dba463aacf4859ad2aab7f031e678c
Publikováno v:
Neuroscience Letters. 686:140-144
We previously showed that knockout mice of hematopoietic prostaglandin (PG) D synthase (H-PGDS) produce less PGD2 to exacerbate pentylenetetrazole (PTZ)-induced seizures. Here, we adopted a gain-of-function strategy and used transgenic mice that over
Autor:
Yoshihiro Urade, Yoan Cherasse, Kosuke Aritake, Aya Imanishi, Masashi Yanagisawa, Mahesh K. Kaushik, Takashi Kanbayashi
Publikováno v:
Sleep. 44(8)
Orexins/hypocretins are hypothalamic neuropeptides that promote and stabilize wakefulness by binding to the orexin receptor type-1 (OX1R) and type-2 (OX2R). Disruption of orexinergic signaling results in the sleep disorder narcolepsy in mice, rats, d
Autor:
Masashi Yanagisawa, Tadashi Ichikawa, Tetsuo Shimizu, Takashi Kanbayashi, Aya Imanishi, Mahesh K. Kaushik, Yoshihiro Urade, Kosuke Aritake
Publikováno v:
Proceedings of the National Academy of Sciences. 115:6046-6051
Narcolepsy-cataplexy is a chronic neurological disorder caused by loss of orexin (hypocretin)-producing neurons, associated with excessive daytime sleepiness, sleep attacks, cataplexy, sleep paralysis, hypnagogic hallucinations, and fragmentation of
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports
Scientific Reports
Octacosanol, a component of various food materials, possesses prominent biological activities and functions. It fights against cellular stress by increasing glutathione level and thus scavenging oxygen reactive species. However, its anti-stress activ
Autor:
Takashi Kanbayashi, Kosuke Aritake, Yoshihiro Urade, M. Kakizaki, Mahesh K. Kaushik, Masashi Yanagisawa
Publikováno v:
Sleep Medicine. 64:S190-S191