MicroRNA-216a is essential for cardiac angiogenesis

Autor: Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins

Publikováno v: Juni, R P, Kocken, J M M, Abreu, R C, Ottaviani, L, Davalan, T, Duygu, B, Poels, E M, Vasilevich, A, Hegenbarth, J C, Appari, M, Bitsch, N, Olieslagers, S, Schrijvers, D M, Stoll, M, Heineke, J, de Boer, J, de Windt, L J & da Costa Martins, P A 2023, ' MicroRNA-216a is essential for cardiac angiogenesis ', Molecular Therapy, vol. 31, no. 6, pp. 1807-1828 . https://doi.org/10.1016/j.ymthe.2023.04.007
Molecular Therapy, 31(6), 1807-1828. Nature Publishing Group

While it is experimentally supported that impaired myocardial vascularization contributes to a mismatch between myocardial oxygen demand and supply, a mechanistic basis for disruption of coordinated tissue growth and angiogenesis in heart failure rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4cdfbed4c34e65e260ef80ffb25f52
https://research.vumc.nl/en/publications/afc667a8-f509-4264-b38a-61a3f329b22d

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth

Autor: Paul Leeson, Yasmin Dickinson, Ashley B. Hale, Manu Vatish, Keith M. Channon, Wei Zhang, Christopher Whiteman, Cheryl M.J. Tan, Eileen McNeill, Edward N. Drydale, Mahesh Appari, Gillian Douglas, Grace Z. Yu, Mark J. Crabtree, Nicholas J. Alp, Adam J. Lewandowski, Surawee Chuaiphichai

Publikováno v: Hypertension (Dallas, Tex. : 1979)

Supplemental Digital Content is available in the text.
Abnormal uteroplacental remodeling leads to placental hypoperfusion, causing fetal growth restriction and pregnancy-related hypertension, which are associated with endothelial dysfunction an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072fe4acd2422bf280a36fdd7a7d0f68
https://pubmed.ncbi.nlm.nih.gov/34757766

Male Gender Identity in Complete Androgen Insensitivity Syndrome

Autor: Stan Monstrey, Piet Hoebeke, Griet De Cuypere, Guy T'Sjoen, Mahesh Appari, F. Kenneth Freedman, Paul-Martin Holterhus, Martine Cools, John Van Borsel

Publikováno v: Archives of Sexual Behavior. 40:635-638

Women and girls with complete androgen insensitivity syndrome (CAIS) invariably have a female typical core gender identity. In this case report, we describe the first case of male gender identity in a CAIS individual raised female leading to complete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ef85117cddbf7eab4db46fef9540ab
https://doi.org/10.1007/s10508-010-9624-1

On Brucella pathogenesis:looking for the unified challenge in systems and synthetic biology

Autor: Srikanth Chiliveru, Mahesh Appari, Prashanth Suravajhala

Publikováno v: Chiliveru, S, Appari, M & Suravajhala, P 2015, ' On Brucella pathogenesis : looking for the unified challenge in systems and synthetic biology ', Systems and synthetic biology, vol. 9, no. 1-2, pp. 73-75 . https://doi.org/10.1007/s11693-014-9158-2

Brucellosis is a zoonotic infection transmitted to humans from infected animals and is one of the widely spread zoonoses. Recently, six species were recognized within the genus Brucella wherein B. melitensis, B. suis and B. abortus are considered vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a5bf87afe55f4a982e3e8369de2f15
https://pure.au.dk/portal/da/publications/on-brucella-pathogenesis(7ddb7dc3-c371-4233-85b4-80ccbbb050f2).html

Androgen Receptor Function Links Human Sexual Dimorphism to DNA Methylation

Autor: Felix G. Riepe, Trevor Bunch, Reiner Siebert, Ole Ammerpohl, Mahesh Appari, Olaf Hiort, Ralf Werner, Ieuan A. Hughes, Bernhard Korn, Paul-Martin Holterhus, Yvonne G. van der Zwan, Stenvert L. S. Drop, Susanne Bens, Martine Cools, Frans W. Verheijen

Publikováno v: PLoS ONE; Vol 8
PLoS One (print), 8(9). Public Library of Science
PLoS ONE, Vol 8, Iss 9, p e73288 (2013)
PLOS ONE
PLoS ONE

Sex differences are well known to be determinants of development, health and disease. Epigenetic mechanisms are also known to differ between men and women through X-inactivation in females. We hypothesized that epigenetic sex differences may also res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949a697ac0ccb7b8bd209a7d0c4d430c
https://doi.org/10.1371/journal.pone.0073288