Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Maher Qabar"'
Publikováno v:
Tetrahedron Letters. 44:583-586
Asymmetric synthesis of the two enantiomers of a small molecule thrombin inhibitor is described. The key step in the synthesis is the glucose-directed chiral induction in the hetero Diels–Alder cycloaddition step. Conformational analysis indicates
Publikováno v:
Synthetic Communications. 32:1741-1749
The efficient synthesis of several new and novel 4-substituted triazolidindiones (urazoles) starting from isocyanates, amines, anilines and carboxylic acids is reported.
Autor:
Hwa-Ok Kim, Joseph Patrick Meara, Michael G. Kahn, Maher Qabar, Mark D. Ferguson, Christopher Lum
Publikováno v:
Tetrahedron Letters. 39:5895-5898
Several dipeptide mimics, 3-alkoxyazetidin-2-ones, were prepared in a diastereoselective fashion by the direct displacement of a scalemic triflate with 3-hydroxyazetidin-2-ones. The scope and limitation are presented.
Publikováno v:
Tetrahedron. 53:11171-11178
The F2Pmp derivatives were prepared in 80–90% yield from commercially available protected l-4-iodophenylalanine by esterification with diazomethane followed by a CuCl-mediated coupling to (diethylphosphonyl) difluoromethylcadmium bromide. Moreover,
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:673-676
A library of conformationally constrained reverse turn mimetics of the HIV V3 loop was screened against the mAb 50.1. Addition of a T h -cell epitope to the reverse turn template provided an immunogen which, when immunized (either in alum or IFA), ge
Publikováno v:
Letters in Peptide Science. 3:25-30
Nature has used a ‘library approach’ to constructing ligands for specific receptors and enzymes by combining a limited functional diversity of 20 amino acid side chains with a small array of secondary structure motifs — reverse turns, α-helice
Autor:
Michael G. Kahn, Maher Qabar
Publikováno v:
Tetrahedron Letters. 37:965-968
The title compound (2) was synthesized in 5 steps from D-serine. In the absence of protection of the carboxyl group, the β-lactam nucleus underwent a facile rearrangement to provide the undesired diazabicyclo[4.3.0] nonane compound, under acidic or
Autor:
Jean-Rene Ella Menye, Amber Paschal, Mary G. Prieve, Sean D. Monahan, Maher Qabar, Michael E. Houston, Allen Li, Alex Baturevych, Pierrot Harvie, Eric Bell, Matt Waldheim, Teri Blevins, Anna Galperin, Debashish Roy
Publikováno v:
Molecular Therapy. 24:S66
Messenger RNA (mRNA) is a promising alternative in both the viral and non-viral DNA-based gene delivery fields. Current viral vectors for gene therapy are associated with serious safety concerns and nonviral vectors are limited by low gene transfer e
Publikováno v:
Tetrahedron. 49:10219-10228
Reaction of alkyl isocyanides with vinyl isocyanates affords highly functionalized pyrrolinone and hydroindolone products via a novel [1+4] cyclization process.
Autor:
James H. Rigby, Maher Qabar
Publikováno v:
ChemInform. 23