Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Maher N. Younes"'
Autor:
Samar A. Jasser, Mahitosh Mandal, Gordon B. Mills, Adel K. El-Naggar, Maher N. Younes, Sun Jin Kim, Jeffrey N. Myers
Publikováno v:
British Journal of Cancer. 124:1747-1747
The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and survival, is mutated or activated in a wide variety of cancers. Akt appears to
Autor:
Waun Ki Hong, Seung Hyun Oh, Merril S. Kies, Woo-Young Kim, Ho-Young Lee, Pinchas Cohen, Maher N. Younes, Jai-Hyun Kim, Adel K. El-Naggar, Fadlo R. Khuri, Jeffrey N. Myers
Publikováno v:
Clinical Cancer Research. 25:4861-4861
Autor:
Gilbert J. Cote, Erich M. Sturgis, Thereasa A. Rich, Bruno D. Fornage, Michelle D. Williams, Maher N. Younes, Nancy D. Perrier, Steven G. Waguespack, F. Chris Holsinger, Douglas B. Evans, Mimi I. Hu, Robert F. Gagel, Jeffrey N. Myers, Beth S Edeiken-Monroe, Douglas P. Monroe, Gary L. Clayman, Elizabeth G. Grubbs, Randal S. Weber, Daniel A. Anaya, Guojun Li, Gregg A Staerkel, James I. Cohen
Publikováno v:
Current Problems in Surgery. 45:156-250
Autor:
John C. Reed, A. K. Ei-Naggar, Michael E. Kupferman, Ge Zhou, E. D. Emberley, Shu-ichi Matsuzawa, Jing Lin, Vyomesh Patel, Jeffrey N. Myers, Samar A. Jasser, Jorge S. Gutkind, Maher N. Younes, Mei Zhao, Peter H. Watson, Daisuke Sano, Alfredo A. Santillan, T. X. Xie
Publikováno v:
Oncogene. 27:3527-3538
Overexpression of S100A7 (psoriasin), a small calcium-binding protein, has been associated with the development of psoriasis and carcinomas in different types of epithelia, but its precise functions are still unknown. Using human tissue specimens, cu
Autor:
Samar A. Jasser, Zhuoying Wang, Yasemin D. Yazici, Seungwon Kim, Geetika Chakravarty, Jeffrey N. Myers, Adel K. El-Naggar, Maher N. Younes, Corazon D. Bucana, Alfredo A. Santillan
Publikováno v:
Clinical Cancer Research. 12:4755-4765
Purpose: The insulin-like growth factor-I receptor (IGF-IR) and its ligands have been implicated in the pathogenesis and progression of various cancers, including those arising in the thyroid gland. We therefore evaluated whether the IGF-IR could ser
Autor:
Seungwon Kim, Yasemin D. Yazici, Jeffrey N. Myers, Adel K. El-Naggar, Maher N. Younes, Samar A. Jasser
Publikováno v:
Clinical Cancer Research. 12:3425-3434
Purpose: Patients with radioiodine-resistant follicular thyroid cancer (FTC) have a poor prognosis, if metastasized, with currently available treatment modalities. Epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) and their
Autor:
James Ludwick, Mahitosh Mandal, Gordon B. Mills, Maher N. Younes, Jeffrey N. Myers, Dao Doan, Orhan G. Yigitbasi, Samar A. Jasser, Adel K. El-Naggar, Andrea Barber McMurphey, Eric A. Swan, Cora Bucana
Publikováno v:
Oral Oncology. 42:430-439
Therapies that target signaling pathways critical to the pathogenesis and progression of squamous cell carcinoma of the head and neck (HNSCC) are needed. One such target, phosphatidylinositol 3-kinase, and its downstream target serine/threonine kinas
Autor:
Mahitosh Mandal, Samar A. Jasser, Adel K. El-Naggar, Bradley A. Schiff, Gordon B. Mills, Benjamin N. Bekele, Yasemin D. Yazici, Jeffrey N. Myers, Orhan G. Yigitbasi, Maher N. Younes, Seungwon Kim
Publikováno v:
Molecular Cancer Therapeutics. 4:1146-1156
We investigated integrin-linked kinase (ILK), a focal adhesion serine-threonine protein kinase, as a new molecular target for treating anaplastic thyroid cancer. ILK mediates cell growth and survival signals and is overexpressed in a number of cancer
Autor:
Benjamin N. Bekele, Isaiah J. Fidler, Mahitosh Mandal, Yasemin D. Yazici, Samar A. Jasser, Sun Jin Kim, Valerie S. Hawthorne, Young Wook Park, Corazon D. Bucana, Maher N. Younes, Jeffrey N. Myers, Orhan G. Yigitbasi
Publikováno v:
Cancer Research. 65:4716-4727
Patients suffering from bone metastases of follicular thyroid carcinoma (FTC) have a poor prognosis because of the lack of effective treatment strategies. The overexpression of epidermal growth factor receptor (EGFR) associated with increased vascula
Autor:
Sun Jin Kim, Mahitosh Mandal, Gordon B. Mills, Adel K. El-Naggar, Samar A. Jasser, Jeffrey N. Myers, Maher N. Younes
Publikováno v:
British Journal of Cancer. 92:1899-1905
The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and survival, is mutated or activated in a wide variety of cancers. Akt appears to