Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Maher Al‐Saif"'
Autor:
Zeyad Muazzen, Walid Moghrabi, Tala Bakheet, Linah Mahmoud, Maher Al-Saif, Khalid S. A. Khabar, Edward G. Hitti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Glucocorticoids (GC) like dexamethasone (Dex) are potent anti-inflammatory agents with diverse cellular functions including the potentiation of the activity of AU-rich elements (AREs). AREs are cis-acting instability sequence elements locate
Externí odkaz:
https://doaj.org/article/41f8c1bd4da6413b9fafd53175f244c2
Publikováno v:
Oncogenesis, Vol 10, Iss 9, Pp 1-11 (2021)
Abstract Amplification of specific cancer genes leads to their over-expression contributing to tumor growth, spread, and drug resistance. Little is known about the ability of these amplified oncogenes to augment the expression of cancer genes through
Externí odkaz:
https://doaj.org/article/f4dd9cf583a24f0ba2326f7fb64215cd
Autor:
Qamraa H. Al‐Qahtani, Walid N. Moghrabi, Suhad Al‐Yahya, Latifa Al‐Haj, Maher Al‐Saif, Linah Mahmoud, Falah Al‐Mohanna, Norah Al‐Souhibani, Ayodele Alaiya, Edward Hitti, Khalid S. A. Khabar
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2120-2139 (2021)
Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE).
Externí odkaz:
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
Autor:
Mysoon M. Al-Ansari, Maher Al-Saif, Maria Arafah, Abdelmonneim M. Eldali, Asma Tulbah, Taher Al-Tweigeri, Abdelhabib Semlali, Khalid S. Khabar, Abdelilah Aboussekhra
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background Most breast cancer-associated fibroblasts (CAFs) are active and important cancer-promoting cells, with significant impact on patient prognosis. Therefore, we investigated here the role of the protein kinase ATR in breast stromal f
Externí odkaz:
https://doaj.org/article/3ba1da8a49ab492aadff73a319d53652
Autor:
Nisha Patel, Arif O. Khan, Maher Al-Saif, Walid N. Moghrabi, Balsam M. AlMaarik, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Tarfa Alshidi, Eman Alobeid, Rana A. Alomar, Saad Al-Harbi, Mohamed Abouelhoda, Khalid S. A. Khabar, Fowzan S. Alkuraya
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Variable expressivity is a well-known phenomenon in which patients with mutations in one gene display varying degrees of clinical severity, potentially displaying only subsets of the clinical manifestations associated with the mul
Externí odkaz:
https://doaj.org/article/1b2694375998473488e8741b9e6ca008
Autor:
Huda H Al-Khalaf, Dilek Colak, Maher Al-Saif, Albandary Al-Bakheet, Siti-Faujiah Hendrayani, Nujoud Al-Yousef, Namik Kaya, Khalid S Khabar, Abdelilah Aboussekhra
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21111 (2011)
BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and
Externí odkaz:
https://doaj.org/article/d7f9ff83f9be405ab2aa0df2055b4300
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Overall list the over-expressed ARE-mRNAs in breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ccd07a744646eb0ff8c95a819165fc
https://doi.org/10.1158/0008-5472.22412201
https://doi.org/10.1158/0008-5472.22412201
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Defects in AU-rich elements (ARE)-mediated posttranscriptional control can lead to several abnormal processes that underlie carcinogenesis. Here, we performed a systematic analysis of ARE-mRNA expression across multiple cancer types. First, the ARE d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3758d6f1d8fd764eec01a63f69178e40
https://doi.org/10.1158/0008-5472.c.6508388.v1
https://doi.org/10.1158/0008-5472.c.6508388.v1
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Supplemental methods on statistical correlation modeling, RNA-IP, and Taqman assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588b9c1555826e077b1fc51ec4f6861f
https://doi.org/10.1158/0008-5472.22412210
https://doi.org/10.1158/0008-5472.22412210
Autor:
Khalid S.A. Khabar, Gilles Pagès, Balázs Győrffy, Renaud Grépin, András Lánczky, Mohamed M. Shoukri, Maher Al-Saif, Maha Al-Ghamdi, Suhad Al-Yahya, Walid Moghrabi, Norah Al-Souhibani, Tala Bakheet, Edward Hitti
Correlation data of the mRNA levels for TTP, HuR, TTP/HuR ratio with ARE- and non-ARE mRNA expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283688b3c9ecc580eca972d6f1b4cafb
https://doi.org/10.1158/0008-5472.22412198.v1
https://doi.org/10.1158/0008-5472.22412198.v1