Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Mahendra Deonarain"'
Publikováno v:
Antibodies, Vol 2, Iss 2, Pp 270-305 (2013)
Photodynamic therapy (PDT) is a clinically-approved but rather under-exploited treatment modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to activate a photochemical reaction between a light activated drug (p
Externí odkaz:
https://doaj.org/article/f91ad8652de74549a20339d3d8037b5f
Autor:
Luisa De Sordi, M Adil Butt, Hayley Pye, Darina Kohoutova, Charles A Mosse, Gokhan Yahioglu, Ioanna Stamati, Mahendra Deonarain, Sinan Battah, Derren Ready, Elaine Allan, Peter Mullany, Laurence B Lovat
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135039 (2015)
Clostridium difficile is the leading cause of antibiotic-associated diarrhoea and pseudo membranous colitis in the developed world. The aim of this study was to explore whether Photodynamic Antimicrobial Chemotherapy (PACT) could be used as a novel a
Externí odkaz:
https://doaj.org/article/3983fc8c2d2e4ea7aa83a596de34085a
Autor:
Laura Bouche, Ashleigh Stewart, Bryan Edwards, Mahendra Deonarain, Yahioglu Gokhan, Ioanna Stamati, Anja Pomowski, Ben Stenton, Soraya Diez-Posada, Isabel Perez-Castro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89834f7a88c36df2e85dde892e9d6f0
https://doi.org/10.1021/scimeetings.0c07458
https://doi.org/10.1021/scimeetings.0c07458
Autor:
Mahendra Deonarain, Gokhan Yahioglu
Publikováno v:
Expert opinion on drug discovery. 16(6)
Introduction: Antibody-Drug Conjugates (ADCs) have undergone a recent resurgence with 5 product approvals over the last 2 years but for those close to the field, it’s been repeated cycles of setbac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b022b520e5fb93b6ac8916d4303842c
https://pubmed.ncbi.nlm.nih.gov/33275475
https://pubmed.ncbi.nlm.nih.gov/33275475
Publikováno v:
Journal of Clinical Oncology. 40:96-96
96 Background: The tumor suppressor gene TP53 is one of the most frequently deleted or mutated genes in gastrointestinal cancers. Normal p53 regulates several important proteins that control cell cycle, cell death, DNA damage/repair, stemness, differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4569ffc06a858320eb21519036c4dc9b
https://doi.org/10.1200/jco.2022.40.4_suppl.096
https://doi.org/10.1200/jco.2022.40.4_suppl.096
Autor:
Ashleigh Stewart, Ioanna Stamati, Sam Ness, Soraya Diez-Posada, Isabel Perez-Castro, Laura Bouche, Anja Pomowski, Quinn Xue, Triin Jurgenson, Mahendra Deonarain, Monika Maciuszek, Malcolm Ngiam, Gokhan Yahioglu, Bryan Edwards
Publikováno v:
Cancer Research. 81:909-909
Despite the recent resurgence, Antibody Drug Conjugates (ADCs) are failing to address challenging cancer indications due to 3 critical limitations: Low potency, ineffective solid-tumour penetration and poor tolerability. The industry is well-served b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf08afe9fcf35b25f88014d934c7810
https://doi.org/10.1158/1538-7445.am2021-909
https://doi.org/10.1158/1538-7445.am2021-909
Autor:
Laura Bouche, Mahendra Deonarain, Gokhan Yahioglu, Ioanna Stamati, Soraya Diez-Posada, Isabel Perez-Castro, Ben Stenton, Bryan Edwards, Quinn Xue, Malcolm Ngiam, Anja Pomowski, Ashleigh Stewart
Publikováno v:
Cancer Research. 80:2901-2901
Antibody Drug Conjugates (ADCs) are failing due to 3 critical limitations: Low potency, ineffective solid-tumour penetration and poor tolerability. The industry is full of approaches where full-length Immunoglobulins have been engineered to carry def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65b8fe8179a66b83a8776808a8b94e9
https://doi.org/10.1158/1538-7445.am2020-2901
https://doi.org/10.1158/1538-7445.am2020-2901
Autor:
Konstantinos Kapnisis, Agamemnon A. Epenetos, Christina Kousparou, Marianna Prokopi, Andreas S. Anayiotos, Mahendra Deonarain, Costas Pitsillides
Publikováno v:
Journal of Clinical Oncology. 38:e17601-e17601
Presented in American Society of Clinical Oncology Annual Meeting, 2020 Notch signalling is implicated in tumorigenesis prompting scientists to research and develop anti-Notch therapeutics. Drugging the Notch pathway has been a challenge due to sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c1de6fb2dbff33d2bd149f1e17867
https://doi.org/10.1200/jco.2020.38.15_suppl.e17601
https://doi.org/10.1200/jco.2020.38.15_suppl.e17601
Autor:
Dahmane Oukrif, Michael Gandy, Mahendra Deonarain, Rehan Haidry, Marco Novelli, Manuel Rodriguez-Justo, Halla W. Reinert, Rifat Hamoudi, Laura Funnell, I Puccio, Saif Khan, Savvas Saouros, Vinay Sehgal, Ioanna Stamati, Jared S Marklew, Gokhan Yahioglu, Hayley Pye, Mohammed A. Butt, Laurence Lovat, Hayley C. Whitaker, Maryam Qurashi
Publikováno v:
Oncotarget
Early oesophageal adenocarcinoma (OA) and pre-neoplastic dysplasia may be treated with endoscopic resection and ablative techniques such as photodynamic therapy (PDT). Though effective, discrete areas of disease may be missed leading to recurrence. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add356b563ba2a6080a55ca9f32bf731
https://pubmed.ncbi.nlm.nih.gov/29796164
https://pubmed.ncbi.nlm.nih.gov/29796164
Publikováno v:
Antibodies, Vol 2, Iss 2, Pp 270-305 (2013)
Photodynamic therapy (PDT) is a clinically-approved but rather under-exploited treatment modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to activate a photochemical reaction between a light activated drug (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa4e62070177ddeebbd1ba7beebd892
https://doi.org/10.3390/antib2020270
https://doi.org/10.3390/antib2020270