Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Autor: Candice Sartre, François Peurois, Marie Ley, Marie-Hélène Kryszke, Wenhua Zhang, Delphine Courilleau, Rodolphe Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianferani, Yann Ferrandez, Jacqueline Cherfils

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current mo

Externí odkaz: https://doaj.org/article/2dfbc0bf1f07489eb3703f383bb0e99c

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Autor: Jacqueline Cherfils, Candice Sartre, Yann Ferrandez, François Peurois, Marie Ley, Wenhua Zhang, Marie-Hélène Kryszke, Delphine Courilleau, Rodolphe P. Fischmeister, Yves Ambroise, Mahel Zeghouf, Sarah Cianferani, Gérald Peyroche

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major physiological transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63af2fa72d2ccb592ecb97d9a2deae34
https://doi.org/10.21203/rs.3.rs-2608569/v1

A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF.

Autor: Marcia Folly-Klan, Eric Alix, Danièle Stalder, Pampa Ray, Lionel V Duarte, Anna Delprato, Mahel Zeghouf, Bruno Antonny, Valérie Campanacci, Craig R Roy, Jacqueline Cherfils

Publikováno v: PLoS Pathogens, Vol 9, Iss 11, p e1003747 (2013)

The intracellular bacterial pathogen Legionella pneumophila (Lp) evades destruction in macrophages by camouflaging in a specialized organelle, the Legionella-containing vacuole (LCV), where it replicates. The LCV maturates by incorporating ER vesicle

Externí odkaz: https://doaj.org/article/a560f605e7b34f1e9e3975483972bfaa

Pressure study reveals conformational landscapes and structural transitions of small GTPase

Autor: Jinqiu Wang, Siwen Zhang, Mahel Zeghouf, Jacqueline Cherfils, Scott A. McCallum, Richard E. Gillilan, Catherine A. Royer

Publikováno v: Biophysical Journal. 121:181a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac55ee47093f5607c47aced5db5edfac
https://doi.org/10.1016/j.bpj.2021.11.1833

PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Autor: Marie-Hélène Kryszke, Emmanuelle Charafe-Jauffret, Raphaël Rodriguez, Christophe Ginestier, Mahel Zeghouf, Agata Nawrotek, Tatiana Cañeque, Robert P. St.Onge, Supaporn Niyomchon, Guri Giaever, Jacqueline Cherfils, Sarah Benabdi, Livia Tepshi, Corey Nislow, Angelica Mariani

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, 2019, 15 (4), pp.358-366. ⟨10.1038/s41589-019-0228-3⟩
Nature Chemical Biology, Nature Publishing Group, 2019, 15 (4), pp.358-366. ⟨10.1038/s41589-019-0228-3⟩

International audience; Peripheral membrane proteins orchestrate many physiological and pathological processes, making regulation of their activities by small molecules highly desirable. However, they are often refractory to classical competitive inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf49604c7f1363915cf982a0ba48231
https://hal.science/hal-02371687