Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Maheedhar Kodali"'
Autor:
Maheedhar Kodali, Leelavathi N. Madhu, Venkata Sai Vashishta Kolla, Sahithi Attaluri, Charles Huard, Yogish Somayaji, Bing Shuai, Chase Jordan, Xiaolan Rao, Sanath Shetty, Ashok K. Shetty
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-23 (2024)
Abstract Background Chronic Gulf War Illness (GWI) is characterized by cognitive and mood impairments, as well as persistent neuroinflammation and oxidative stress. This study aimed to investigate the efficacy of Epidiolex®, a Food and Drug Administ
Externí odkaz:
https://doaj.org/article/bdbff770ddb04c3cb3105d2ca65a4300
Autor:
Gunel Ayyubova, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Yogish Somayaji, Bing Shuai, Shama Rao, Goutham Shankar, Ashok K. Shetty
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-26 (2023)
Abstract Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating robust antiinflammatory activity. The lack of tumorigenic and immu
Externí odkaz:
https://doaj.org/article/babb73ba873d43e5aaae3a4f6631489f
Autor:
Sahithi Attaluri, Jenny Jaimes Gonzalez, Maha Kirmani, Andrew D. Vogel, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Shama Rao, Bing Shuai, Roshni S. Babu, Charles Huard, Ashok K. Shetty
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionExtracellular vesicles (EVs) released by human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) have robust antiinflammatory and neurogenic properties due to therapeutic miRNAs and proteins in their cargo. Hence, hiP
Externí odkaz:
https://doaj.org/article/e4e8b5ccc0e949989622b4d274e104c8
Autor:
Maheedhar Kodali, Leelavathi N. Madhu, Roxanne L. Reger, Bojana Milutinovic, Raghavendra Upadhya, Sahithi Attaluri, Bing Shuai, Goutham Shankar, Ashok K. Shetty
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
An optimal intranasal (IN) dose of human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs), 90 min post-traumatic brain injury (TBI), has been reported to prevent the evolution of acute neuroinflammation into chronic neuroinflammation r
Externí odkaz:
https://doaj.org/article/36f3707b4509431c8309c61dea5d49e0
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 503-507 (2022)
The expanded lifespan of people, while a positive advance, has also amplified the prevalence of age-related disorders, which include mild cognitive impairment, dementia, and Alzheimer’s disease. Therefore, competent therapies that could improve the
Externí odkaz:
https://doaj.org/article/840c5f97ce834c64ba0d1e33b827cc31
Autor:
Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Persistent cognitive impairment is a primary central nervous system-related symptom in veterans afflicted with chronic Gulf War Illness (GWI). Previous studies in a rat model have revealed that cognitive dysfunction in chronic GWI is associated with
Externí odkaz:
https://doaj.org/article/ba118f28ff8246a8b94e4a9c263e89eb
Autor:
Leelavathi N. Madhu, Maheedhar Kodali, Sahithi Attaluri, Bing Shuai, Laila Melissari, Xiaolan Rao, Ashok K. Shetty
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101973- (2021)
Persistent cognitive and mood dysfunction is the primary CNS symptom in veterans afflicted with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for improving cognitive and mood function with antioxidant, antiinflammato
Externí odkaz:
https://doaj.org/article/5ae7dfe88a3c4317932546b932bc2633
Autor:
Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C. Abba, Ashok K. Shetty, C. Marcelo Aldaz
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 163-176 (2019)
The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented. These include spinocerebellar ataxia, epilepsy and mental retardation (SCAR12, OMIM: 614322) a
Externí odkaz:
https://doaj.org/article/b2b23f03ce6f4a2397a5ee27171f943e
Autor:
Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Daniel Leite Góes Gitaí, Marisa R Pinson, Maheedhar Kodali, Geetha Shetty, Gabriele Zanirati, Smrithi Kumar, Bing Shuai, Susan T Weintraub, Ashok K. Shetty
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Grafting of neural stem cells (NSCs) derived from human induced pluripotent stem cells (hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have hindered their clinical application. Employing nano-sized extracellular
Externí odkaz:
https://doaj.org/article/55e99e5169b6426db87d3eaff82cb865
Autor:
Ashok K. Shetty, Sahithi Attaluri, Maheedhar Kodali, Bing Shuai, Geetha A. Shetty, Dinesh Upadhya, Bharathi Hattiangady, Leelavathi N. Madhu, Raghavendra Upadhya, Adrian Bates, Xiaolan Rao
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Enduring brain dysfunction is amid the highly manifested symptoms in veterans with Gulf War Illness (GWI). Animal studies have established that lasting brain dysfunction in GWI is concomitant with augmented oxidative stress, inflammation, and decline
Externí odkaz:
https://doaj.org/article/9dd3f2a1ba9d44738b30013b745efc4f